NCT-501

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Product Name: NCT-501
CAS No.: 1802088-50-1
Chemical Name: NCT-501
Synonyms: CS-2069;NCT-501;NCT-501 >=98% (HPLC);NCT-501, 10 mM in DMSO;Inhibitor,Aldehyde Dehydrogenase (ALDH),inhibit,NCT-501,NCT 501;8-((4-(cyclopropanecarbonyl)piperazin-1-yl)methyl)-7-isopentyl-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione;8-((4-(cyclopropanecarbonyl)piperazin-1-yl)methyl)-7-isopentyl-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione , NCT-501;1H-Purine-2,6-dione, 8-[[4-(cyclopropylcarbonyl)-1-piperazinyl]methyl]-3,7-dihydro-1,3-dimethyl-7-(3-methylbutyl)-
CBNumber: CB73043300
Molecular Formula: C21H32N6O3
Formula Weight: 416.52
MOL File: 1802088-50-1.mol

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NCT-501 Property

Boiling point:: 627.3±65.0 °C(Predicted)
Density: 1.37±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥20.85 mg/mL in DMSO with gentle warming; insoluble in H2O; ≥11 mg/mL in EtOH
form: solid
pka: 5.26±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21162
Product name: NCT-501
Purity: ≥98%
Packaging: 1mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 21162
Product name: NCT-501
Purity: ≥98%
Packaging: 5mg
Price: $233
Updated: 2024/03/01

Cayman Chemical

Product number: 21162
Product name: NCT-501
Purity: ≥98%
Packaging: 10mg
Price: $412
Updated: 2024/03/01

Cayman Chemical

Product number: 21162
Product name: NCT-501
Purity: ≥98%
Packaging: 25mg
Price: $887
Updated: 2024/03/01

AK Scientific

Product number: 4502EC
Product name: 8-[[4-(Cyclopropanecarbonyl)piperazin-1-yl]methyl]-1,3-dimethyl-7-(3-methylbutyl)purine-2,6-dione
Packaging: 25mg
Price: $1086
Updated: 2021/12/16

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NCT-501 Chemical Properties,Usage,Production

Description

NCT-501 is a potent, reversible, theophylline-based inhibitor of ALDH1A1 (IC₅₀ = 40 nM for the human form). It is selective for ALDH1A1 over other ALDH isozymes as well as other dehydrogenases. Pharmacokinetic studies indicate that NCT-501 has high bioavailability when delivered intraperitoneally, with rapid phase I modification in the liver.

References

yang s m, yasgar a, miller b, et al. discovery of nct-501, a potent and selective theophylline-based inhibitor of aldehyde dehydrogenase 1a1 (aldh1a1)[j]. journal of medicinal chemistry, 2015, 58(15): 5967-5978.

NCT-501 Preparation Products And Raw materials

Raw materials

Preparation Products

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1802088-50-1, NCT-501Related Search:

NCT-501

CS-2069

1H-Purine-2,6-dione, 8-[[4-(cyclopropylcarbonyl)-1-piperazinyl]methyl]-3,7-dihydro-1,3-dimethyl-7-(3-methylbutyl)-

NCT-501 >=98% (HPLC)

Inhibitor,Aldehyde Dehydrogenase (ALDH),inhibit,NCT-501,NCT 501

8-((4-(cyclopropanecarbonyl)piperazin-1-yl)methyl)-7-isopentyl-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione

8-((4-(cyclopropanecarbonyl)piperazin-1-yl)methyl)-7-isopentyl-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione , NCT-501

NCT-501, 10 mM in DMSO

1802088-50-1