IMETIT DIHYDROBROMIDE
- Product Name
- IMETIT DIHYDROBROMIDE
- CAS No.
- 32385-58-3
- Chemical Name
- IMETIT DIHYDROBROMIDE
- Synonyms
- Imetit hydrobromide;Imetit dihydrobromid;IMETIT DIHYDROBROMIDE;VUF 8325 dihydrobromide;SKF 91105 dihydrobromide;S-[2-(Imidazol-4-yl)ethyl]isothiourea2HBr;IMETIT DIHYDROBROMIDE POTENT AND SELECTI VE;5-[2-(IMIDAZOL-4-YL)ETHYL]ISOTHIOUREA DIHYDROBROMIDE;S-[2-(IMIDAZOL-4-YL)ETHYL]ISOTHIOUREA DIHYDROBROMIDE;S-[2-(4(5)-Imidazolyl)ethyl]isothiourea dihydrobromide
- CBNumber
- CB7305203
- Molecular Formula
- C6H12Br2N4S
- Formula Weight
- 332.06
- MOL File
- 32385-58-3.mol
IMETIT DIHYDROBROMIDE Property
- storage temp.
- Store at RT
- solubility
- H2O: soluble
- form
- solid
- color
- off-white
- Water Solubility
- Freely soluble in water, practically insoluble in acetone /n
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- I135
- Product name
- Imetit dihydrobromide
- Purity
- ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $162
- Updated
- 2024/03/01
- Product number
- I135
- Product name
- Imetit dihydrobromide
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $293
- Updated
- 2024/03/01
- Product number
- J62346
- Product name
- Imetit dihydrobromide, 98%
- Packaging
- 50mg
- Price
- $375.65
- Updated
- 2024/03/01
- Product number
- J62346
- Product name
- Imetit dihydrobromide, 98%
- Packaging
- 25mg
- Price
- $173
- Updated
- 2021/12/16
- Product number
- 29517
- Product name
- Imetit (hydrobromide)
- Packaging
- 5mg
- Price
- $73
- Updated
- 2024/03/01
IMETIT DIHYDROBROMIDE Chemical Properties,Usage,Production
Description
Imetit is a histamine H3 and H4 receptor agonist (Kis = 0.3 and 2.7 nM, respectively, in radioligand binding assays). It is selective for histamine H3 and H4 receptors over H1 and H2 receptors at concentrations up to 100 μM, as well as the serotonin (5-HT) receptor subtype 5-HT3 (Ki = 240 nM)., Imetit reduces potassium-induced increases in histamine levels in isolated rat cerebral cortex slices (EC50 = 2.8 nM). It increases scratching in mice (ED50 = 0.9 μmol), an effect that is reduced by the H3 receptor antagonist thioperamide .
Uses
Imetit dihydrobromide is a high affinity agonist at the histamine H3- and H4-receptors.
Definition
ChEBI: A hydrobromide salt obtained by reaction of imetit with two equivalents of hydrobromic acid. An extremely potent, high affinity agonist at H3 and H4 receptors (Ki values are 0.3 and 2.7 nM respectively). Induces sh pe change in eosinophils with an EC50 of 25 nM. Centrally active following systemic administration.
Biological Activity
An extremely potent, high affinity agonist at H 3 and H 4 receptors (K i values are 0.3 and 2.7 nM respectively). Induces shape change in eosinophils with an EC 50 of 25 nM. Centrally active following systemic administration. Also available as part of the Histamine H 3 Receptor Tocriset™ .
Biochem/physiol Actions
Potent and selective H3 histamine receptor agonist.
storage
Store at RT