Azido-PEG3-(CH2)3OH

Product Name: Azido-PEG3-(CH2)3OH
CAS No.: 1807512-36-2
Chemical Name: Azido-PEG3-(CH2)3OH
Synonyms: N3-PEG3-PPG1-OH;Azido-PEG3-C3-OH;N3-PEG3-CH2CH2CH2OH;Azido-PEG3-(CH2)3OH;α-Azido-ω-propanl poly(ethylene glycol);3-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]-1-propanol;1-Propanol, 3-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-
CBNumber: CB73062349
Molecular Formula: C9H19N3O4
Formula Weight: 233.27
MOL File: 1807512-36-2.mol

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Azido-PEG3-(CH2)3OH Property

storage temp.: Storage temp. 2-8°C
solubility: Soluble in Water, DMSO, DCM, DMF
form: Liquid
color: Colorless to light yellow
InChI: InChI=1S/C9H19N3O4/c10-12-11-2-5-15-7-9-16-8-6-14-4-1-3-13/h13H,1-9H2
InChIKey: UUSDGPCVMBHTRJ-UHFFFAOYSA-N
SMILES: C(COCCN=[N+]=[N-])OCCOCCCO

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-22794
Product name: Azido-PEG3-(CH2)3OH
Purity: 98%
Packaging: 500mg
Price: $600
Updated: 2021/12/16

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Azido-PEG3-(CH2)3OH Chemical Properties,Usage,Production

Description

Azido-PEG3-(CH2)3OH is a PEG linker with three carbon chain between PEG fragemnt and OH group, The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.

Uses

Azido-PEG3-C3-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG3-C3-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Azido-PEG3-(CH2)3OH Preparation Products And Raw materials

Raw materials

Preparation Products

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1807512-36-2, Azido-PEG3-(CH2)3OHRelated Search:

Azido-PEG3-(CH2)3OH

N3-PEG3-CH2CH2CH2OH

α-Azido-ω-propanl poly(ethylene glycol)

Azido-PEG3-C3-OH

1-Propanol, 3-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-

N3-PEG3-PPG1-OH

3-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]-1-propanol

1807512-36-2

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