AR-13324 (hydrochloride)

Product Name: AR-13324 (hydrochloride)
CAS No.: 1253952-02-1
Chemical Name: AR-13324 (hydrochloride)
Synonyms: AR-13324;Netarsudil;AR13324 HCl;AR-13324 HCl;Netarsudil (AR-13324);Netarsudil hydrochloride;AR-13324 (hydrochloride);AR-13324 dihydrochloride;Netarsudil dihydrochloride;Netarsudil (AR-13324) 2HCl
CBNumber: CB73066998
Molecular Formula: C28H29Cl2N3O3
Formula Weight: 526.45416
MOL File: 1253952-02-1.mol

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AR-13324 (hydrochloride) Property

storage temp.: Store at -20°C
solubility: ≥26.3 mg/mL in H2O with gentle warming and ultrasonic; insoluble in EtOH; ≥7.783 mg/mL in DMSO
form: solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ApexBio Technology

Product number: B7807
Product name: Netarsudil(AR-13324)
Packaging: 2mg
Price: $140
Updated: 2021/12/16

ApexBio Technology

Product number: B7807
Product name: Netarsudil(AR-13324)
Packaging: 5mg
Price: $270
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611535
Product name: Netarsudil
Packaging: 100mg
Price: $606.9
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611531
Product name: Netarsudil dihydrochloride
Packaging: 100mg
Price: $606.9
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611535
Product name: Netarsudil
Packaging: 250mg
Price: $912.9
Updated: 2021/12/16

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AR-13324 (hydrochloride) Chemical Properties,Usage,Production

Biological Activity

ki: 0.2-10.3 nmnetarsudil (ar-13324) is a rock inhibitor.the rho kinases are serine/threonine protein kinases existing as 2 isoforms, rock1 and rock2, which are widely expressed in various tissues, such as the trabecular meshwork. rock can promote the assembly of actin stress fibers and focal adhesions and can also regulate cell contraction and motility.

in vitro

previous study showed that at the cellular level, netarsudil had been shown to be able to induce loss of actin stress fibers, cell shape changes, loss of focal adhesions, as well as changes in extracellular matrix composition of tm cells [1].

in vivo

animal efficacy study found that the topical treatment of netarsudil was able to affect both proximal (trabecular meshwork and schlemm's canal) and distal portions (intrascleral vessels) of the mouse conventional outflow tract [2].

References

[1] sturdivant jm et al. discovery of the rock inhibitor netarsudil for the treatment of open-angle glaucoma. bioorg med chem lett. 2016 may 15;26(10):2475-80.
[2] li g et al. visualization of conventional outflow tissue responses to netarsudil in living mouse eyes. eur j pharmacol. 2016 sep 15;787:20-31.

AR-13324 (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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AR-13324 (hydrochloride) Suppliers

China 51 India 1 United States 6 Global 58

Shanghai Boyle Chemical Co., Ltd.

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