ChemicalBook > CAS DataBase List > OTS514

OTS514

Uses

Product Name: OTS514
CAS No.: 1338540-63-8
Chemical Name: OTS514
Synonyms: CS-2532;OTS514 HCl;OTS514;OTS 514;OTS-514;9-[4-[(1R)-2-Amino-1-methylethyl]phenyl]-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-one;9-{4-[(2R)-1-aminopropan-2-yl]phenyl}-8-hydroxy-6-methyl-4H,5H-thieno[2,3-c]quinolin-4-one;Thieno[2,3-c]quinolin-4(5H)-one, 9-[4-[(1R)-2-amino-1-methylethyl]phenyl]-8-hydroxy-6-methyl-;cancer,Apoptosis,multiple,arrest,cycle,myeloma,OTS514,HMCL,inhibit,positive,Inhibitor,cell,TOPK
CBNumber: CB73067016
Molecular Formula: C21H20N2O2S
Formula Weight: 364.46
MOL File: 1338540-63-8.mol

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OTS514 Property

Boiling point:: 501.3±50.0 °C(Predicted)
Density: 1.293±0.06 g/cm3(Predicted)
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.25 mg/ml
form: A crystalline solid
pka: 9.35±0.20(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17053
Product name: OTS514
Purity: ≥95%
Packaging: 500μg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 17053
Product name: OTS514
Purity: ≥95%
Packaging: 1mg
Price: $176
Updated: 2024/03/01

Cayman Chemical

Product number: 17053
Product name: OTS514
Purity: ≥95%
Packaging: 5mg
Price: $728
Updated: 2024/03/01

TRC

Product number: O712950
Product name: OTS514
Packaging: 1mg
Price: $195
Updated: 2021/12/16

ChemScene

Product number: CS-5047
Product name: OTS514
Purity: 98.15%
Packaging: 2mg
Price: $132
Updated: 2021/12/16

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OTS514 Chemical Properties,Usage,Production

Uses

OTS514 is a potent T-lymphokine-activated killer cell-originated protein kinase (TOPK) inhibitor. TOPK is involved with cancer cell proliferation and cancer stem cell maintenance. OTS514 also downregulates the oncogenic transcriptional factor, forkhead box protein M1 (FOXM1).

Uses

in vivo

OTS514 (1-5 mg/kg; once a day for 2 weeks; intravenous administration) induces tumor regression in a xenograft model of A549 cells (TOPK-positive lung cancer cells)^[1].

Animal Model:	Female BALB/cSLC-nu/nu mice bearing a xenograft model of A549 cells^[1]
Dosage:	1, 2.5, and 5 mg/kg
Administration:	Intravenously treated; once every day for 2 weeks
Result:	Resulted in tumor growth inhibition (TGI) of 5.7, 43.3, and 65.3% on day 15, respectively, without any body weight loss.

OTS514 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from OTS514 manufacturers

Henan Fengda Chemical Co., Ltd

Product: OTS514 1338540-63-8
Price: US $8.00-2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-24

1338540-63-8, OTS514Related Search:

CS-2532

OTS514;OTS 514;OTS-514

OTS514 HCl

9-[4-[(1R)-2-Amino-1-methylethyl]phenyl]-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-one

Thieno[2,3-c]quinolin-4(5H)-one, 9-[4-[(1R)-2-amino-1-methylethyl]phenyl]-8-hydroxy-6-methyl-

cancer,Apoptosis,multiple,arrest,cycle,myeloma,OTS514,HMCL,inhibit,positive,Inhibitor,cell,TOPK

9-{4-[(2R)-1-aminopropan-2-yl]phenyl}-8-hydroxy-6-methyl-4H,5H-thieno[2,3-c]quinolin-4-one

1338540-63-8