ChemicalBook > CAS DataBase List > FIT-039

FIT-039

Product Name: FIT-039
CAS No.: 1113044-49-7
Chemical Name: FIT-039
Synonyms: FIT-039;FIT-039 (FIT039);FIT-039, 10 mM in DMSO;N-[5-Fluoro-2-(1-piperidinyl)phenyl]-4-pyridinecarbothioamide;N-(5-fluoro-2-(piperidin-1-yl)phenyl)pyridine-4-carbothioamide;4-Pyridinecarbothioamide, N-[5-fluoro-2-(1-piperidinyl)phenyl]-;Cytomegalovirus,HSV-1,Herpes simplex virus,transcription,Inhibitor,DNA,CDK,Cyclin dependent kinase,CDK9,CMV,FIT 039,mRNA,FIT039,viruses,antiviral,inhibit,orally,FIT-039,polymerase-II,HSV-2,DNA/RNA Synthesis,HSV
CBNumber: CB73067546
Molecular Formula: C17H18FN3S
Formula Weight: 315.41
MOL File: 1113044-49-7.mol

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FIT-039 Property

storage temp.: 2-8°C
solubility: DMSO:55.0(Max Conc. mg/mL);174.38(Max Conc. mM)
form: A solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2861
Product name: FIT-039
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $62.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2861
Product name: FIT-039
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $268
Updated: 2025/07/31

ChemScene

Product number: CS-0014657
Product name: FIT-039
Purity: ≥98.0%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

DC Chemicals

Product number: DC21015
Product name: FIT-039
Purity: >98%
Packaging: 100mg
Price: $700
Updated: 2021/12/16

DC Chemicals

Product number: DC21015
Product name: FIT-039
Purity: >98%
Packaging: 250mg
Price: $1300
Updated: 2021/12/16

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FIT-039 Chemical Properties,Usage,Production

Description

FIT-039 is a novel cyclin-dependent kinase 9 (CDK9) inhibitor, suppressing replication of a broad spectrum of DNA viruses through inhibition of mRNA transcription.

Uses

FIT-039 is a selective, ATP-competitive and orally active CDK9 inhibitor with an IC50 of 5.8 μM for CKD9/cyclin T1. FIT-039 does not inhibit other CDKs and other kinases. FIT-039 inhibits replication of HSV-1 (IC50 of 0.69 μM), HSV-2, human adenovirus, and human CMV. FIT-039 is a promising antiviral agent for inhibiting drug-resistant HSVs and other DNA viruses.

in vivo

Treatment with the FIT-039 ointment twice a day suppresses skin lesions and rescues mice (male BALB/c mice injected with HSV-1) from lethality in a dose-dependent manner. The healing of lesions is observed with 5% to 10% FIT-039 ointment, leading to the complete regression of zosteriform spread on day 10, which is also observed with the 5% ACV ointment^[1].
FIT-039 does not affect body weight gain in mice administrated with an overdose of this compound (1000 mg/kg/d) for 14 days, and no changes are observed in biological markers in their blood^[1].

target

FIT-039 is a selective, ATP-competitive and orally active CDK9 inhibitor with an IC50 of 5.8 μM for CKD9/cyclin T1. FIT-039 inhibits replication of HSV-1 (IC50 of 0.69 μM), HSV-2, human adenovirus, and human CMV.

IC 50

CDK9/cyclinT1: 5.8 μM (IC₅₀); HSV-1: 0.69 μM (IC₅₀); HSV-2; CMV

References

[1] Makoto Yamamoto, et al. CDK9 Inhibitor FIT-039 Prevents Replication of Multiple DNA Viruses. J Clin Invest. 2014 Aug;124(8):3479-88. DOI:10.1172/JCI73805

FIT-039 Preparation Products And Raw materials

Raw materials

Preparation Products

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1113044-49-7, FIT-039Related Search:

FIT-039

FIT-039 (FIT039)

4-Pyridinecarbothioamide, N-[5-fluoro-2-(1-piperidinyl)phenyl]-

N-(5-fluoro-2-(piperidin-1-yl)phenyl)pyridine-4-carbothioamide

N-[5-Fluoro-2-(1-piperidinyl)phenyl]-4-pyridinecarbothioamide

Cytomegalovirus,HSV-1,Herpes simplex virus,transcription,Inhibitor,DNA,CDK,Cyclin dependent kinase,CDK9,CMV,FIT 039,mRNA,FIT039,viruses,antiviral,inhibit,orally,FIT-039,polymerase-II,HSV-2,DNA/RNA Synthesis,HSV

FIT-039, 10 mM in DMSO

1113044-49-7