ChemicalBook > CAS DataBase List > TSI-01

TSI-01

Product Name
TSI-01
CAS No.
704878-75-1
Chemical Name
TSI-01
Synonyms
TSI-01;isopropyl 4-(3,4-dichloro-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoate;Benzoic acid, 4-(3,4-dichloro-2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-, 1-methylethyl ester
CBNumber
CB73067586
Molecular Formula
C14H11Cl2NO4
Formula Weight
328.15
MOL File
704878-75-1.mol
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TSI-01 Property

Melting point:
150-152°C
storage temp. 
Amber Vial, -20°C Freezer, Under inert atmosphere
solubility 
DMSO (Slightly), Ethyl Acetate (Slightly)
form 
Solid
color 
Light Yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
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N-Bromosuccinimide Price

Cayman Chemical
Product number
17628
Product name
TSI-01
Purity
≥95%
Packaging
1mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
17628
Product name
TSI-01
Purity
≥95%
Packaging
5mg
Price
$216
Updated
2024/03/01
Cayman Chemical
Product number
17628
Product name
TSI-01
Purity
≥95%
Packaging
10mg
Price
$380
Updated
2024/03/01
Cayman Chemical
Product number
17628
Product name
TSI-01
Purity
≥95%
Packaging
25mg
Price
$830
Updated
2024/03/01
TRC
Product number
T895525
Product name
TSI-01
Packaging
100mg
Price
$1020
Updated
2021/12/16
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TSI-01 Chemical Properties,Usage,Production

Description

Platelet-activating factor (PAF) is a pro-inflammatory phospholipid mediator that is rapidly synthesized by lyso-PAF acetyltransferase (lyso-PAFAT) in response to extracellular stimuli. Two types of lyso-PAFAT have been identified: lysophosphatidylcholine acyltransferase (LPCAT)1, which is mostly expressed in the lungs, and LPCAT2, which is expressed in inflammatory cells. TSI-01 is a selective inhibitor of LPCAT2 (IC50s = 0.47 versus 3.02 μM for human LPCAT2 and LPCAT1, respectively). At 60 μM it was shown to suppress PAF biosynthesis in mouse peritoneal macrophages stimulated with a calcium ionophore.

Uses

TSI-01 is a selectve inhibitor of LPCAT2, a platelet-activiating factor acetyltransferase (PAFAT) which acts as a pro-inflammatory phospholipid mediator. Inhibition leads to suppression of PAF biosynthesis.

TSI-01 Preparation Products And Raw materials

Raw materials

Preparation Products

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TSI-01 Suppliers

China 26 United Kingdom 1 United States 4 Global 31
Pharmacodia (Beijing) Co.,Ltd
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704878-75-1, TSI-01Related Search:


  • TSI-01
  • isopropyl 4-(3,4-dichloro-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoate
  • Benzoic acid, 4-(3,4-dichloro-2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-, 1-methylethyl ester
  • 704878-75-1