VK-II-86

Product Name: VK-II-86
CAS No.: 955371-84-3
Chemical Name: VK-II-86
Synonyms: VK-II-86;4-(9H-carbazol-4-yloxy)-1-[2-(2-methoxyphenoxy)ethylamino]butan-2-ol;2-Butanol, 4-(9H-carbazol-4-yloxy)-1-[[2-(2-methoxyphenoxy)ethyl]amino]-
CBNumber: CB73067591
Molecular Formula: C25H28N2O4
Formula Weight: 420.5
MOL File: 955371-84-3.mol

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VK-II-86 Property

Boiling point:: 660.6±55.0 °C(Predicted)
Density: 1.230±0.06 g/cm3(Predicted)
solubility: DMSO: Soluble
form: A solid
pka: 14.43±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific

Product number: SYN5131
Product name: VK-II-86
Packaging: 50mg
Price: $760
Updated: 2021/12/16

DC Chemicals

Product number: DC43858
Product name: VK-II-86
Purity: >98%
Packaging: 100mg
Price: $700
Updated: 2021/12/16

DC Chemicals

Product number: DC43858
Product name: VK-II-86
Purity: >98%
Packaging: 1g
Price: $2600
Updated: 2021/12/16

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VK-II-86 Chemical Properties,Usage,Production

Uses

VK-II-86 is a Carvedilol (HY-B0006) analogue lacking antagonist activity at β-adrenoceptors, in hypokalaemia. VK-II-86 prevents hypokalaemia-induced ventricular arrhythmia through multi-channel effects. VK-II-86 prevents all hypokalaemia-induced changes in ion channel activity and oxidative stress[1].

in vivo

VK-II-86 markedly reduces the number of non-sustained and sustained ventricular tachyarrhythmias in the hypokalaemic murine whole-heart model^[1].

References

[1] Robinson VM, et al. A carvedilol analogue, VK-II-86, prevents hypokalaemia-induced ventricular arrhythmia through novel multi-channel effects. Br J Pharmacol. 2022 Jun;179(11):2713-2732. DOI:10.1111/bph.15775

VK-II-86 Preparation Products And Raw materials

Raw materials

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955371-84-3, VK-II-86Related Search:

VK-II-36

VK-II-86

4-(9H-carbazol-4-yloxy)-1-[2-(2-methoxyphenoxy)ethylamino]butan-2-ol

2-Butanol, 4-(9H-carbazol-4-yloxy)-1-[[2-(2-methoxyphenoxy)ethyl]amino]-

955371-84-3