1-(2-bromo-4-methylthiazol-5-yl)ethanone

Product Name: 1-(2-bromo-4-methylthiazol-5-yl)ethanone
CAS No.: 1093106-54-7
Chemical Name: 1-(2-bromo-4-methylthiazol-5-yl)ethanone
Synonyms: 2-bromo-4-methyl-5-acetylthiazole;1-(2-bromo-4-methyl-5-thiazolyl)ethanone;1-(2-bromo-4-methylthiazol-5-yl)ethanone;Ethanone, 1-(2-bromo-4-methyl-5-thiazolyl)-;1-(2-bromo-4-methylthiazol-5-yl)ethan-1-one;1-(2-bromo-4-methyl-1,3-thiazol-5-yl)ethanone;1-(2-bromo-4-methyl-1,3-thiazol-5-yl)ethan-1-one
CBNumber: CB73082714
Molecular Formula: C6H6BrNOS
Formula Weight: 220.09
MOL File: 1093106-54-7.mol

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1-(2-bromo-4-methylthiazol-5-yl)ethanone Property

Boiling point:: 279.3±20.0 °C(Predicted)
Density: 1.616±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -0.42±0.10(Predicted)
Appearance: Light yellow to yellow Liquid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Activate Scientific

Product number: AS147423
Product name: 1-(2-Bromo-4-methylthiazol-5-yl)ethanone
Purity: 97%
Packaging: 1g
Price: $449
Updated: 2021/12/16

Crysdot

Product number: CD11353651
Product name: 1-(2-Bromo-4-methylthiazol-5-yl)ethanone
Purity: 95+%
Packaging: 5g
Price: $891
Updated: 2021/12/16

Crysdot

Product number: CD11353651
Product name: 1-(2-Bromo-4-methylthiazol-5-yl)ethanone
Purity: 95+%
Packaging: 10g
Price: $1188
Updated: 2021/12/16

Alichem

Product number: 1093106547
Product name: 1-(2-Bromo-4-methylthiazol-5-yl)ethanone
Packaging: 5g
Price: $1206
Updated: 2021/12/16

Chemcia Scientific

Product number: BB20-3318
Product name: 1-(2-Bromo-4-methyl-thiazol-5-yl)-ethanone
Purity: 95%
Packaging: 5G
Price: $1385
Updated: 2021/12/16

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1-(2-bromo-4-methylthiazol-5-yl)ethanone Chemical Properties,Usage,Production

Synthesis

30748-47-1

1093106-54-7

5-Acetyl-2-amino-4-methylthiazole (200 mg, 1.26 mmol) was used as starting material and suspended in acetonitrile (ACN, 15 mL). Copper bromide (286 mg, 1.0 eq.) and isoamyl nitrite (511 μL, 3.0 eq.) were added sequentially. The reaction mixture was heated to reflux for 3 hours. After completion of the reaction, the reaction solution was diluted with dichloromethane (DCM) and washed sequentially with saturated brine and ethylenediaminetetraacetic acid (EDTA) solution. The organic phase was dried with anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure to remove the solvent. Purification by silica gel column chromatography (eluent: dichloromethane) afforded 263 mg of the target compound 1-(2-bromo-4-methylthiazol-5-yl)ethanone in 94% yield as a yellow oil. The structure of the product was confirmed by 1H NMR (75 MHz, CDCl3): δ 2.71 (3H, s, 4-CH3), 2.51 (3H, s, 6-CH3), which is consistent with literature data (PCT Int. Appl., 2010128163). High-resolution mass spectrometry (HRMS-ESI) analysis showed that the calculated value of [MNa+] was 219.94262 and the measured value was 219.24264.

References

[1] Patent: WO2017/21549, 2017, A1. Location in patent: Page/Page column 70-71
[2] European Journal of Medicinal Chemistry, 2017, vol. 139, p. 762 - 772
[3] Patent: EP2540718, 2013, A1. Location in patent: Page/Page column 18
[4] Patent: WO2013/931, 2013, A1. Location in patent: Page/Page column 30

1-(2-bromo-4-methylthiazol-5-yl)ethanone Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(2-bromo-4-methylthiazol-5-yl)ethanone Suppliers

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1093106-54-7, 1-(2-bromo-4-methylthiazol-5-yl)ethanoneRelated Search:

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2-bromo-4-methyl-5-acetylthiazole

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1093106-54-7