BOC-L-Methionine

Product Name: BOC-L-Methionine
CAS No.: 2488-15-5
Chemical Name: BOC-L-Methionine
Synonyms: BOC-MET;Boc-Met-O;BOC-L-MET;BOC-MET-OH;BOC-L-MET-OH;Boc-D-Met-OH;BOC-METHIONINE;BOC-L-METHIONINE;Boc-Met-OH (Oil);BOC-L-METHIONENE
CBNumber: CB7309504
Molecular Formula: C10H19NO4S
Formula Weight: 249.33
MOL File: 2488-15-5.mol

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BOC-L-Methionine Property

Melting point:: 47-50 °C(lit.)
alpha: -23 º (c=1.3, methanol)
Boiling point:: 415.5±40.0 °C(Predicted)
Density: 1.160±0.06 g/cm3(Predicted)
refractive index: -22 ° (C=1.3, AcOH)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: almost transparency in Methanol
form: Powder
pka: 3.83±0.10(Predicted)
color: White to off-white
optical activity: [α]20/D 22°, c = 1 in methanol
BRN: 1727869
CAS DataBase Reference: 2488-15-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38
Safety Statements: 24/25-36-26
WGK Germany: 3
F: 9-23
HS Code: 2930 90 98

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.53054
Product name: Boc-Met-OH
Purity: Novabiochem?
Packaging: 25g
Price: $104
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.53054
Product name: Boc-Met-OH
Purity: Novabiochem?
Packaging: 100g
Price: $395
Updated: 2025/07/31

Sigma-Aldrich

Product number: 408425
Product name: Boc-Met-OH
Purity: 99%
Packaging: 5g
Price: $58.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: 408425
Product name: Boc-Met-OH
Purity: 99%
Packaging: 25g
Price: $109
Updated: 2025/07/31

TCI Chemical

Product number: B1636
Product name: N-(tert-Butoxycarbonyl)-L-methionine
Purity: >98.0%(HPLC)(T)
Packaging: 10g
Price: $64
Updated: 2025/07/31

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BOC-L-Methionine Chemical Properties,Usage,Production

Chemical Properties

white to off-white microcrystalline powder

Uses

N-Boc-L-methionine is an N-Boc-protected form of L-Methionine (M260440). L-Methionine is an essential amino acid that is obtained from our diet. L-Methionine can be found in grain legumes (such as lentils), and poultry. L-Methionine’s main function is to act as the primary “Start” sequence on mRNA so that the ribosomes can start translating the mRNA into proteins.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

63-68-3

24424-99-5

2488-15-5

Example 1 [0041] 7.2 g of L-methionine was dissolved in a solvent mixture of 50 mL of water and 50 mL of acetonitrile. To this solution was added 2 g of sodium hydroxide (0.05 mol). The reaction mixture was cooled to 0 °C, followed by the slow addition of 10.9 g of di-tert-butyl dicarbonate (0.05 mol). After addition, the reaction system was gradually warmed to room temperature (24-25 °C) and the reaction was continuously stirred for 12 hours. After completion of the reaction, the acetonitrile was removed by rotary evaporation. To the residual aqueous phase, potassium carbonate was added and the pH was adjusted to 12. The aqueous phase was extracted twice with 50 mL of dichloromethane and the organic phase was discarded. To the aqueous phase, 1 N hydrochloric acid was added dropwise and the pH was adjusted to 6. The aqueous phase was again extracted twice with 50 mL of dichloromethane, the organic phases were combined, washed with 50 mL of saturated sodium chloride solution, dried with anhydrous sodium sulfate, and concentrated under reduced pressure to give viscous Boc-L-methionine (11.4 g) in 95% yield. The product was characterized by 1H NMR (500 MHz, CDCl3): δ 11.62 (br, 1H), 6.91 (br, 1H), 4.40 (m, 1H), 2.52 (t, J = 4.8 Hz, 2H), 2.05 (s, 3H), 1.92-2.15 (m, 2H), 1.42 (s, 9H). Mass spectrometry (MS) showed a molecular ion peak (M + 1) of 250.

References

[1] Antimicrobial Agents and Chemotherapy, 2017, vol. 61, # 3,
[2] Tetrahedron Letters, 1994, vol. 35, # 14, p. 2121 - 2124
[3] Patent: EP2647624, 2013, A1. Location in patent: Paragraph 0040; 0041
[4] Organic Syntheses, 1985, vol. 63, p. 160 - 160
[5] Tetrahedron Letters, 2018, p. 4267 - 4271

BOC-L-Methionine Preparation Products And Raw materials

Raw materials

Preparation Products

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BOC-L-Methionine Suppliers

Americas 1 Belgium 3 China 209 Europe 3 France 2 Germany 8 India 19 Italy 2 Japan 9 South Korea 1 Switzerland 6 United Kingdom 16 United States 53 Global 332

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
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Meryer (Shanghai) Chemical Technology Co., Ltd.

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Alfa Aesar

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TCI (Shanghai) Development Co., Ltd.

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Beijing HwrkChemical Technology Co., Ltd

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Energy Chemical

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GL Biochem (Shanghai) Ltd

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Capot Chemical Co., Ltd

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Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

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Jia Xing Isenchem Co.,Ltd

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View Lastest Price from BOC-L-Methionine manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-Met-OH 2488-15-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T
Release date: 2023-11-21

Henan Fengda Chemical Co., Ltd

Product: BOC-L-Methionine 2488-15-5
Price: US $100.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-23

Career Henan Chemical Co

Product: BOC-L-Methionine 2488-15-5
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KG
Release date: 2018-08-15

2488-15-5, BOC-L-MethionineRelated Search:

tert-Butyl carbazate N-Carbobenzyloxyglycine Zinc methionine sulfate 1,1'-Carbonyldiimidazole L-Selenomethionine S-ADENOSYL-L-METHIONINE DL-Methionine L-Methionine DI-TERT-BUTYL ETHER 4-N-BOC-AMINO-4-CARBOXYTETRAHYDROTHIOPYRAN BOC-L-METHIONINE (O),BOC-L-METHIONINE SULFOXIDE,N-ALPHA-T-BOC-L-METHIONINE-D,L-SULFOXIDE BOC-MET-OSU N-alpha-t-boc-L-methionine(dicyclohexylammoniumsaltcrystalline),Boc-L-Methionine·DCHA,Boc-L-methionine dicyclohexylamine salt Carbonyl iron powder N-BOC-D-METHIONINE,N-Boc-D-methionine, 98+%,N-ALPHA-T-BOC-D-METHIONINE,BOC-D-METHIONINE BOC-2-AMINO-4-(ETHYL(THIO))BUTYRIC ACID BOC-L-MET-O-CH2-PHI-CH2-COOH BOC-L-METHIONINE P-NITROPHENYL ESTER,BOC-L-METHIONINE 4-NITROPHENYL ESTER

L-Methionine, N-[(1,1-dimethylethoxy)carbonyl]-

N-(tert-Butoxycarbonyl)-L-methionine ,98%

(S)-2-[(tert-Butyloxycarbonyl)amino]-4-(methylthio)butyric acid

Boc-L-methionine ,98%

Boc-Met-O

N-Boc-L-methionine Boc-Met-OH

(S)-2-((tert-butoxycarbonyl)aMino)-4-(Methylthio)butanoic acid

2-[(2-Methylpropan-2-yl)oxycarbonylamino]-4-methylsulfanylbutanoic acid

N-(tert-Butoxycarbonyl)-L-methionine, Boc-L-methionine

BOC-L-MET-OH

BOC-L-METHIONINE-OH

BOC-L-MET

BOC-L-METHIONINE

BOC-MET-OH

BOC-MET

BOC-METHIONINE

N-ALPHA-TERT-BUTYLOXYCARBONYL-L-METHIONINE

N-ALPHA-T-BUTOXYCARBONYL-L-METHIONINE

N-ALPHA-T-BOC-L-METHIONINE

N-BOC-L-METHIONINE

N-[(1,1-DIMETHYLETHOXY)CARBONYL]-L-METHIONINE

TBOC-L-METHIONINE

(Tert-Butoxy)Carbonyl Met-OH (Solid)

(Tert-Butoxy)Carbonyl Met-OH (Syrup)

N-(TERT-BUTOXYCARBONYL)-L-METHIONINE

N-T-BOC-L-METHIONINE

(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-4-methylsulfanylbutanoic acid

L--Methionine, N-BOC protected

(2S)-2-{[(tert-butoxy)carbonyl]amino}-4-(methylsulfanyl)butanoic acid

(2S)-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]-4-(methylthio)butanoate

Boc-L-methionine - Solid

N-(tert-Butoxycarbonyl)-L-Methionine, 98.0%(LC&T

Boc-Met-OH (Solid)

Boc-Met-OH (Oil)

Boc-L-methionine≥ 99% (HPLC)

T-BUTYLOXYCARBONYL-L-METHIONINE

tert-butoxycarbonyl-L-methionine

N-T-BOC-L-METHIONINE FREE ACIDCRYSTALLIN E

N-(TERT-BUTOXYCARBONYL)-L-METHIONINE, 99 %

BOC-L-Methionine, 99+%

N-ALPHA-T-BUTYLOXYCARBONYL-L-METHIONINE

BOC-L-METHIONENE

BOC-L-METHIONENE FREE ACID

BOC-L-METHIONENE FREE BASE

Boc-D-Met-OH

N-Boc-L-methionine, 98+%

N-(tert-Butoxycarbonyl)-L-methionine &gt

(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-4-methylsulfanylbutanoicaci

BOC-L-Methionine USP/EP/BP

BOC-L-Methionine extrapure, 98.5%

2488-15-5

C10H19NO4S

CH3SCH2CH2CHCOOHNHCOOCCH33

Amino Acid Derivatives

Amino Acids (N-Protected)

Boc-Amino Acids

Protected & Labeled Amino Acids

Peptide Synthesis