ChemicalBook > CAS DataBase List > BOC-L-Methionine

BOC-L-Methionine

Product Name
BOC-L-Methionine
CAS No.
2488-15-5
Chemical Name
BOC-L-Methionine
Synonyms
BOC-MET;Boc-Met-O;BOC-L-MET;BOC-MET-OH;BOC-L-MET-OH;Boc-D-Met-OH;BOC-METHIONINE;BOC-L-METHIONINE;Boc-Met-OH (Oil);BOC-L-METHIONENE
CBNumber
CB7309504
Molecular Formula
C10H19NO4S
Formula Weight
249.33
MOL File
2488-15-5.mol
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BOC-L-Methionine Property

Melting point:
47-50 °C(lit.)
alpha 
-23 º (c=1.3, methanol)
Boiling point:
415.5±40.0 °C(Predicted)
Density 
1.160±0.06 g/cm3(Predicted)
refractive index 
-22 ° (C=1.3, AcOH)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
almost transparency in Methanol
form 
Powder
pka
3.83±0.10(Predicted)
color 
White to off-white
optical activity
[α]20/D 22°, c = 1 in methanol
BRN 
1727869
CAS DataBase Reference
2488-15-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
24/25-36-26
WGK Germany 
3
F 
9-23
HS Code 
2930 90 98
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.53054
Product name
Boc-Met-OH
Purity
Novabiochem?
Packaging
25g
Price
$104
Updated
2025/07/31
Sigma-Aldrich
Product number
8.53054
Product name
Boc-Met-OH
Purity
Novabiochem?
Packaging
100g
Price
$395
Updated
2025/07/31
Sigma-Aldrich
Product number
408425
Product name
Boc-Met-OH
Purity
99%
Packaging
5g
Price
$58.8
Updated
2025/07/31
Sigma-Aldrich
Product number
408425
Product name
Boc-Met-OH
Purity
99%
Packaging
25g
Price
$109
Updated
2025/07/31
TCI Chemical
Product number
B1636
Product name
N-(tert-Butoxycarbonyl)-L-methionine
Purity
>98.0%(HPLC)(T)
Packaging
10g
Price
$64
Updated
2025/07/31
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BOC-L-Methionine Chemical Properties,Usage,Production

Chemical Properties

white to off-white microcrystalline powder

Uses

N-Boc-L-methionine is an N-Boc-protected form of L-Methionine (M260440). L-Methionine is an essential amino acid that is obtained from our diet. L-Methionine can be found in grain legumes (such as lentils), and poultry. L-Methionine’s main function is to act as the primary “Start” sequence on mRNA so that the ribosomes can start translating the mRNA into proteins.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

63-68-3

24424-99-5

2488-15-5

Example 1 [0041] 7.2 g of L-methionine was dissolved in a solvent mixture of 50 mL of water and 50 mL of acetonitrile. To this solution was added 2 g of sodium hydroxide (0.05 mol). The reaction mixture was cooled to 0 °C, followed by the slow addition of 10.9 g of di-tert-butyl dicarbonate (0.05 mol). After addition, the reaction system was gradually warmed to room temperature (24-25 °C) and the reaction was continuously stirred for 12 hours. After completion of the reaction, the acetonitrile was removed by rotary evaporation. To the residual aqueous phase, potassium carbonate was added and the pH was adjusted to 12. The aqueous phase was extracted twice with 50 mL of dichloromethane and the organic phase was discarded. To the aqueous phase, 1 N hydrochloric acid was added dropwise and the pH was adjusted to 6. The aqueous phase was again extracted twice with 50 mL of dichloromethane, the organic phases were combined, washed with 50 mL of saturated sodium chloride solution, dried with anhydrous sodium sulfate, and concentrated under reduced pressure to give viscous Boc-L-methionine (11.4 g) in 95% yield. The product was characterized by 1H NMR (500 MHz, CDCl3): δ 11.62 (br, 1H), 6.91 (br, 1H), 4.40 (m, 1H), 2.52 (t, J = 4.8 Hz, 2H), 2.05 (s, 3H), 1.92-2.15 (m, 2H), 1.42 (s, 9H). Mass spectrometry (MS) showed a molecular ion peak (M + 1) of 250.

References

[1] Antimicrobial Agents and Chemotherapy, 2017, vol. 61, # 3,
[2] Tetrahedron Letters, 1994, vol. 35, # 14, p. 2121 - 2124
[3] Patent: EP2647624, 2013, A1. Location in patent: Paragraph 0040; 0041
[4] Organic Syntheses, 1985, vol. 63, p. 160 - 160
[5] Tetrahedron Letters, 2018, p. 4267 - 4271

BOC-L-Methionine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from BOC-L-Methionine manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Boc-Met-OH 2488-15-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T
Release date
2023-11-21
Henan Fengda Chemical Co., Ltd
Product
BOC-L-Methionine 2488-15-5
Price
US $100.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-23
Career Henan Chemical Co
Product
BOC-L-Methionine 2488-15-5
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000KG
Release date
2018-08-15

2488-15-5, BOC-L-MethionineRelated Search:

tert-Butyl carbazate N-Carbobenzyloxyglycine Zinc methionine sulfate 1,1'-Carbonyldiimidazole L-Selenomethionine S-ADENOSYL-L-METHIONINE DL-Methionine L-Methionine DI-TERT-BUTYL ETHER 4-N-BOC-AMINO-4-CARBOXYTETRAHYDROTHIOPYRAN BOC-L-METHIONINE (O),BOC-L-METHIONINE SULFOXIDE,N-ALPHA-T-BOC-L-METHIONINE-D,L-SULFOXIDE BOC-MET-OSU N-alpha-t-boc-L-methionine(dicyclohexylammoniumsaltcrystalline),Boc-L-Methionine·DCHA,Boc-L-methionine dicyclohexylamine salt Carbonyl iron powder N-BOC-D-METHIONINE,N-Boc-D-methionine, 98+%,N-ALPHA-T-BOC-D-METHIONINE,BOC-D-METHIONINE BOC-2-AMINO-4-(ETHYL(THIO))BUTYRIC ACID BOC-L-MET-O-CH2-PHI-CH2-COOH BOC-L-METHIONINE P-NITROPHENYL ESTER,BOC-L-METHIONINE 4-NITROPHENYL ESTER

  • L-Methionine, N-[(1,1-dimethylethoxy)carbonyl]-
  • N-(tert-Butoxycarbonyl)-L-methionine ,98%
  • (S)-2-[(tert-Butyloxycarbonyl)amino]-4-(methylthio)butyric acid
  • Boc-L-methionine ,98%
  • Boc-Met-O
  • N-Boc-L-methionine Boc-Met-OH
  • (S)-2-((tert-butoxycarbonyl)aMino)-4-(Methylthio)butanoic acid
  • 2-[(2-Methylpropan-2-yl)oxycarbonylamino]-4-methylsulfanylbutanoic acid
  • N-(tert-Butoxycarbonyl)-L-methionine, Boc-L-methionine
  • BOC-L-MET-OH
  • BOC-L-METHIONINE-OH
  • BOC-L-MET
  • BOC-L-METHIONINE
  • BOC-MET-OH
  • BOC-MET
  • BOC-METHIONINE
  • N-ALPHA-TERT-BUTYLOXYCARBONYL-L-METHIONINE
  • N-ALPHA-T-BUTOXYCARBONYL-L-METHIONINE
  • N-ALPHA-T-BOC-L-METHIONINE
  • N-BOC-L-METHIONINE
  • N-[(1,1-DIMETHYLETHOXY)CARBONYL]-L-METHIONINE
  • TBOC-L-METHIONINE
  • (Tert-Butoxy)Carbonyl Met-OH (Solid)
  • (Tert-Butoxy)Carbonyl Met-OH (Syrup)
  • N-(TERT-BUTOXYCARBONYL)-L-METHIONINE
  • N-T-BOC-L-METHIONINE
  • (2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-4-methylsulfanylbutanoic acid
  • L--Methionine, N-BOC protected
  • (2S)-2-{[(tert-butoxy)carbonyl]amino}-4-(methylsulfanyl)butanoic acid
  • (2S)-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]-4-(methylthio)butanoate
  • Boc-L-methionine - Solid
  • N-(tert-Butoxycarbonyl)-L-Methionine, 98.0%(LC&T
  • Boc-Met-OH (Solid)
  • Boc-Met-OH (Oil)
  • Boc-L-methionine≥ 99% (HPLC)
  • T-BUTYLOXYCARBONYL-L-METHIONINE
  • tert-butoxycarbonyl-L-methionine
  • N-T-BOC-L-METHIONINE FREE ACIDCRYSTALLIN E
  • N-(TERT-BUTOXYCARBONYL)-L-METHIONINE, 99 %
  • BOC-L-Methionine, 99+%
  • N-ALPHA-T-BUTYLOXYCARBONYL-L-METHIONINE
  • BOC-L-METHIONENE
  • BOC-L-METHIONENE FREE ACID
  • BOC-L-METHIONENE FREE BASE
  • Boc-D-Met-OH
  • N-Boc-L-methionine, 98+%
  • N-(tert-Butoxycarbonyl)-L-methionine &gt
  • (2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-4-methylsulfanylbutanoicaci
  • BOC-L-Methionine USP/EP/BP
  • BOC-L-Methionine extrapure, 98.5%
  • 2488-15-5
  • C10H19NO4S
  • CH3SCH2CH2CHCOOHNHCOOCCH33
  • Amino Acid Derivatives
  • Amino Acids (N-Protected)
  • Boc-Amino Acids
  • Protected & Labeled Amino Acids
  • Peptide Synthesis