ALA-TYR-PRO-GLY-LYS-PHE-NH2 TRIFLUOROACETATE SALT

Product Name
ALA-TYR-PRO-GLY-LYS-PHE-NH2 TRIFLUOROACETATE SALT
Chemical Name
ALA-TYR-PRO-GLY-LYS-PHE-NH2 TRIFLUOROACETATE SALT
Synonyms
PAR4-AP TFA SALT;AYPGKF-NH2 TFA SALT;AYPGKF-NH2, PAR4-AP;ALA-TYR-PRO-GLY-LYS-PHE-NH2 TRIFLUOROACETATE SALT
CBNumber
CB7311521
Molecular Formula
C36H49F3N8O9
Formula Weight
794.82
MOL File
Mol file
More
Less

ALA-TYR-PRO-GLY-LYS-PHE-NH2 TRIFLUOROACETATE SALT Property

storage temp. 
-20°C
solubility 
H2O: >10mg/mL
form 
solid
More
Less

Safety

Safety Statements 
22-24/25
WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A3227
Product name
Ala-Tyr-Pro-Gly-Lys-Phe-NH2 trifluoroacetate salt
Purity
≥98% (HPLC), solid
Packaging
1mg
Price
$205
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
HCH0066723
Product name
ALA-TYR-PRO-GLY-LYS-PHE-NH2 TRIFLUOROACETATE SALT
Purity
95.00%
Packaging
1MG
Price
$693.69
Updated
2021/12/16
More
Less

ALA-TYR-PRO-GLY-LYS-PHE-NH2 TRIFLUOROACETATE SALT Chemical Properties,Usage,Production

Uses

4-Androsten-11β-ol-3,17-dione has been used in platelet aggregation.

General Description

Ala-Tyr-Pro-Gly-Lys-Phe-NH2 (AYPGKF- NH2) is a selective, specific proteinase-activated receptor 4 (PAR4) agonist peptide. PAR4 is a G-protein-coupled receptor that is expressed on the surface of human platelets and is involved in the thrombin signaling pathway. Cleavage of PAR4 by the protease thrombin stimulates the receptor and results in signaling of platelet aggregation.

Biochem/physiol Actions

AYPGK is a ligand for the PAR4 receptor; binding results in activation of PAR4. AYPGK stimulates platelet aggregation in vitro (EC50 =15 μM) via PAR4. In human platelets treated with the PAR4 agonist, AYPGKF stimulates the production of thromboxane, a potent agent for platelet-aggregation. Additionally, AYPGKF mediates the thrombin-induced release of endostatin from rat platelets.

ALA-TYR-PRO-GLY-LYS-PHE-NH2 TRIFLUOROACETATE SALT Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

ALA-TYR-PRO-GLY-LYS-PHE-NH2 TRIFLUOROACETATE SALT Suppliers

Switzerland 1 United States 1 Global 2
SIGMA-RBI
Tel
--
Fax
--
Country
Switzerland
ProdList
6896
Advantage
91

ALA-TYR-PRO-GLY-LYS-PHE-NH2 TRIFLUOROACETATE SALTRelated Search:


  • AYPGKF-NH2, PAR4-AP
  • ALA-TYR-PRO-GLY-LYS-PHE-NH2 TRIFLUOROACETATE SALT
  • AYPGKF-NH2 TFA SALT
  • PAR4-AP TFA SALT
  • C34H48N8O7