ChemicalBook > CAS DataBase List > 4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester
4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester
- Product Name
- 4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester
- CAS No.
- 205448-64-2
- Chemical Name
- 4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester
- Synonyms
- lenvaint-B;idene)methyL;4-(((2,2-dimethyL;Lenvatinib Impurity 120;)amino)-2-methoxybenzoate;-4,6-dioxo-1,3-dioxan-5-yL;METHYL4-[(2,2-DIMETHYL-4,6;methyl 4-((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methylamino);4-((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methylamino)-2-methoxybenzoate;Methyl 4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)-2-methoxybenzoate
- CBNumber
- CB73116376
- Molecular Formula
- C16H17NO7
- Formula Weight
- 335.31
- MOL File
- 205448-64-2.mol
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4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester Property
- Boiling point:
- 547.8±50.0 °C(Predicted)
- Density
- 1.360±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- -3?+-.0.40(Predicted)
- Appearance
- Off-white to yellow Solid
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N-Bromosuccinimide Price
TRC
- Product number
- D481133
- Product name
- 4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoicAcidMethylEster
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
AK Scientific
- Product number
- 4469DA
- Product name
- Methyl4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)-2-methoxybenzoate
- Packaging
- 250mg
- Price
- $103
- Updated
- 2021/12/16
AK Scientific
- Product number
- 4469DA
- Product name
- Methyl4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)-2-methoxybenzoate
- Packaging
- 1g
- Price
- $114
- Updated
- 2021/12/16
Ambeed
- Product number
- A100807
- Product name
- Methyl4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)-2-methoxybenzoate
- Purity
- 97%
- Packaging
- 250mg
- Price
- $25
- Updated
- 2021/12/16
Ambeed
- Product number
- A100807
- Product name
- Methyl4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)-2-methoxybenzoate
- Purity
- 97%
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
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4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester Chemical Properties,Usage,Production
Synthesis
15568-85-1
27492-84-8
205448-64-2
The general procedure for the synthesis of methyl 4-((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)methylamino)-2-methoxybenzoate from 5-(methoxymethylenyl)-2,2-dimethyl-1,3-dioxane-4,6-dione and 2-methoxy-4-aminobenzoic acid methyl ester was as follows: first, 2-methoxy-4-aminobenzoic acid methyl ester (14.15 g, 78 mmol) was suspended in isopropanol and heated at 50 °C. Subsequently, 5-(methoxymethylenyl)-2,2-dimethyl-1,3-dioxohexane-4,6-dione (14.8 g, 80 mmol) was added in batches over 10 min. The reaction mixture was heated to reflux for 30 minutes. After completion of the reaction, the mixture was cooled to room temperature and the precipitate formed was collected by filtration. The precipitate was washed with isopropanol and dried under vacuum to afford the target product 5-((3-methoxy-4-methoxycarbonylanilino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione (25.2 g, 96% yield).
References
[1] Patent: US6809097, 2004, B1. Location in patent: Page column 67
[2] Patent: EP1724268, 2006, A1. Location in patent: Page/Page column 48
[3] Journal of Medicinal Chemistry, 2008, vol. 51, # 6, p. 1649 - 1667
[4] Journal of Medicinal Chemistry, 2008, vol. 51, # 6, p. 1668 - 1680
4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester manufacturers
Moxin Chemicals
- Product
- Lenvatinib Impurity 205448-64-2
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 95%+
- Supply Ability
- 100000
- Release date
- 2025-03-20
Nanjing Fred Technology Co., Ltd
- Product
- 4-[(2,2-Dimethyl-4,6-dioxo-[1,3]-dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester 205448-64-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2023-12-19