3BDO
- Product Name
- 3BDO
- CAS No.
- 890405-51-3
- Chemical Name
- 3BDO
- Synonyms
- 3BDO;3BDO >=98% (HPLC);3-benzyl-5-[(2-nitrophenoxy)methyl]oxolan-2-one;3BDO, 97%, Activator for mTOR, Autophagy inhibitor;3-Benzyl-5-((2-nitrophenoxy)methyl)dihydrofuran-2(3H)-one;Pentonic acid, 2,3-dideoxy-5-O-(2-nitrophenyl)-2-(phenylmethyl)-, γ-lactone;Autophagy,3BDO,mTOR,Apoptosis,Mammalian target of Rapamycin,Inhibitor,inhibit
- CBNumber
- CB73117166
- Molecular Formula
- C18H17NO5
- Formula Weight
- 327.33
- MOL File
- 890405-51-3.mol
3BDO Property
- storage temp.
- 2-8°C
- solubility
- DMSO: 65 mg/ml
- form
- oil
- color
- colorless to light brown
Safety
- HS Code
- 29321900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML1687
- Product name
- 3BDO
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $110
- Updated
- 2023/06/20
- Product number
- SML1687
- Product name
- 3BDO
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $440
- Updated
- 2023/06/20
- Product number
- CS-0035372
- Product name
- 3BDO
- Purity
- 99.91%
- Packaging
- 5mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- CS-0035372
- Product name
- 3BDO
- Purity
- 99.91%
- Packaging
- 10mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- CS-0035372
- Product name
- 3BDO
- Purity
- 99.91%
- Packaging
- 25mg
- Price
- $240
- Updated
- 2021/12/16
3BDO Chemical Properties,Usage,Production
Uses
3BDO has been used to investigate the potential effects of metformin on inflammatory lung injury.
Biochem/physiol Actions
3BDO is a cell-permeable, orally bioavailable, non-toxic butyrolactone derivative that is shown to competitively bind FKBP1A (FK506-binding protein 1A, 12 kDa) in a reversible manner, and suppress autophagy via the mTOR pathway. 3BDO inhibits both LPS- and oxLDL-induced autophagy in HUVECs, increases TIA1 phosphorylation, and reduces autophagosomes number. It is reported to be brain permeant, and significantly decreases atherosclerosis development in apoE-/-?mice (100 mg/kg, q.d., p.o.). 3BDO increases IDE and neprilysin levels, lowers amyloid-β deposition in an AβPP/PS1 transgenic mouse model of Alzheimer′s disease, and alleviates memory deficits.
3BDO Preparation Products And Raw materials
Raw materials
Preparation Products
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