ChemicalBook > CAS DataBase List > 3BDO

3BDO

Product Name
3BDO
CAS No.
890405-51-3
Chemical Name
3BDO
Synonyms
3BDO;3BDO >=98% (HPLC);3-benzyl-5-[(2-nitrophenoxy)methyl]oxolan-2-one;3BDO, 97%, Activator for mTOR, Autophagy inhibitor;3-Benzyl-5-((2-nitrophenoxy)methyl)dihydrofuran-2(3H)-one;Pentonic acid, 2,3-dideoxy-5-O-(2-nitrophenyl)-2-(phenylmethyl)-, γ-lactone;Autophagy,3BDO,mTOR,Apoptosis,Mammalian target of Rapamycin,Inhibitor,inhibit
CBNumber
CB73117166
Molecular Formula
C18H17NO5
Formula Weight
327.33
MOL File
890405-51-3.mol
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3BDO Property

storage temp. 
2-8°C
solubility 
DMSO: 65 mg/ml
form 
oil
color 
colorless to light brown
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Safety

HS Code 
29321900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1687
Product name
3BDO
Purity
≥98% (HPLC)
Packaging
5MG
Price
$110
Updated
2023/06/20
Sigma-Aldrich
Product number
SML1687
Product name
3BDO
Purity
≥98% (HPLC)
Packaging
25MG
Price
$440
Updated
2023/06/20
ChemScene
Product number
CS-0035372
Product name
3BDO
Purity
99.91%
Packaging
5mg
Price
$70
Updated
2021/12/16
ChemScene
Product number
CS-0035372
Product name
3BDO
Purity
99.91%
Packaging
10mg
Price
$110
Updated
2021/12/16
ChemScene
Product number
CS-0035372
Product name
3BDO
Purity
99.91%
Packaging
25mg
Price
$240
Updated
2021/12/16
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3BDO Chemical Properties,Usage,Production

Uses

3BDO has been used to investigate the potential effects of metformin on inflammatory lung injury.

Biochem/physiol Actions

3BDO is a cell-permeable, orally bioavailable, non-toxic butyrolactone derivative that is shown to competitively bind FKBP1A (FK506-binding protein 1A, 12 kDa) in a reversible manner, and suppress autophagy via the mTOR pathway. 3BDO inhibits both LPS- and oxLDL-induced autophagy in HUVECs, increases TIA1 phosphorylation, and reduces autophagosomes number. It is reported to be brain permeant, and significantly decreases atherosclerosis development in apoE-/-?mice (100 mg/kg, q.d., p.o.). 3BDO increases IDE and neprilysin levels, lowers amyloid-β deposition in an AβPP/PS1 transgenic mouse model of Alzheimer′s disease, and alleviates memory deficits.

3BDO Preparation Products And Raw materials

Raw materials

Preparation Products

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3BDO Suppliers

China 44 United States 8 Global 52
ShangHai Caerulum Pharma Discovery Co., Ltd.
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18149758185 18149758185
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Sigma-Aldrich
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Beijing Jin Ming Biotechnology Co., Ltd.
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010-60605840 18892239720
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010-60605840
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Aikon International Limited
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025-58851090 13611564524
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Angel Pharmatech, Ltd.
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Career Henan Chemica Co
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Energy Chemical
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InvivoChem
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Nantong QuanYi Biotechnology Co., Ltd
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890405-51-3, 3BDORelated Search:


  • 3BDO
  • 3BDO, 97%, Activator for mTOR, Autophagy inhibitor
  • Pentonic acid, 2,3-dideoxy-5-O-(2-nitrophenyl)-2-(phenylmethyl)-, γ-lactone
  • 3BDO >=98% (HPLC)
  • 3-Benzyl-5-((2-nitrophenoxy)methyl)dihydrofuran-2(3H)-one
  • Autophagy,3BDO,mTOR,Apoptosis,Mammalian target of Rapamycin,Inhibitor,inhibit
  • 3-benzyl-5-[(2-nitrophenoxy)methyl]oxolan-2-one
  • 890405-51-3