ChemicalBook > CAS DataBase List > "5-(2-amino-4-oxo-3-(2-(trifluoromethyl)phenyl)-3,4-dihydroquinazolin-6-yl)-N-(2,4-difluorophenyl)-2-methoxypyridine-3-sulfonamide "

"5-(2-amino-4-oxo-3-(2-(trifluoromethyl)phenyl)-3,4-dihydroquinazolin-6-yl)-N-(2,4-difluorophenyl)-2-methoxypyridine-3-sulfonamide "

Product Name
"5-(2-amino-4-oxo-3-(2-(trifluoromethyl)phenyl)-3,4-dihydroquinazolin-6-yl)-N-(2,4-difluorophenyl)-2-methoxypyridine-3-sulfonamide "
CAS No.
1384097-27-1
Chemical Name
"5-(2-amino-4-oxo-3-(2-(trifluoromethyl)phenyl)-3,4-dihydroquinazolin-6-yl)-N-(2,4-difluorophenyl)-2-methoxypyridine-3-sulfonamide "
Synonyms
(3S)-GSK-F1;(3S)-GSK-F1, 10 mM in DMSO;5-(2-AMINO-4-OXO-3-(2-(TRIFLUOROMETHYL)PHENYL)-3,4-DIHYDROQUIZOLIN-6-YL)-N-(2,4-DIFLUOROPHENYL)-2-METHOXYPYRIDINE-3-SULFOMIDE;"5-(2-amino-4-oxo-3-(2-(trifluoromethyl)phenyl)-3,4-dihydroquinazolin-6-yl)-N-(2,4-difluorophenyl)-2-methoxypyridine-3-sulfonamide ";3-Pyridinesulfonamide, 5-[(3S)-2-amino-3,4-dihydro-4-oxo-3-[2-(trifluoromethyl)phenyl]-6-quinazolinyl]-N-(2,4-difluorophenyl)-2-methoxy-
CBNumber
CB73120812
Molecular Formula
C27H18F5N5O4S
Formula Weight
603.52
MOL File
1384097-27-1.mol
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Crysdot
Product number
CD11267963
Product name
5-(2-Amino-4-oxo-3-(2-(trifluoromethyl)phenyl)-3,4-dihydroquinazolin-6-yl)-N-(2,4-difluorophenyl)-2-methoxypyridine-3-sulfonamide
Purity
97%
Packaging
100mg
Price
$1080
Updated
2021/12/16
Alichem
Product number
1384097271
Product name
5-(2-Amino-4-oxo-3-(2-(trifluoromethyl)phenyl)-3,4-dihydroquinazolin-6-yl)-N-(2,4-difluorophenyl)-2-methoxypyridine-3-sulfonamide
Packaging
100mg
Price
$1125.63
Updated
2021/12/16
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"5-(2-amino-4-oxo-3-(2-(trifluoromethyl)phenyl)-3,4-dihydroquinazolin-6-yl)-N-(2,4-difluorophenyl)-2-methoxypyridine-3-sulfonamide " Chemical Properties,Usage,Production

Uses

(S)-GSK-F1 (Compound 28) is an inhibitor for type III phosphatidylinositol 4-kinase α (PI4KIIIα). (S)-GSK-F1 inhibits PI4Kα, PI4Kβ, PI4Kγ, PI3Kα, PI3Kβ and PI3Kδ with pIC50 of 8.3, 6.0, 5.6, 5.6, 5.1 and 5.6, respectively. (S)-GSK-F1 exhibits anti-hepatitis C virus (HCV) activity through inhibition of HCV replication. (S)-GSK-F1 exhibits moderate pharmacokinetic characters in rat model[1].

IC 50

PI4KIIIα: 8.3 (pIC50); PI4KIIIβ: 6.0 (pIC50); PI3Kα: 5.6 (pIC50); PI3Kδ: 5.6 (pIC50); PI3Kβ: 5.1 (pIC50)

References

[1] Leivers AL, et al., Discovery of selective small molecule type III phosphatidylinositol 4-kinase alpha (PI4KIIIα) inhibitors as anti hepatitis C (HCV) agents. J Med Chem. 2014 Mar 13;57(5):2091-106. DOI:10.1021/jm400781h

"5-(2-amino-4-oxo-3-(2-(trifluoromethyl)phenyl)-3,4-dihydroquinazolin-6-yl)-N-(2,4-difluorophenyl)-2-methoxypyridine-3-sulfonamide " Preparation Products And Raw materials

Raw materials

Preparation Products

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"5-(2-amino-4-oxo-3-(2-(trifluoromethyl)phenyl)-3,4-dihydroquinazolin-6-yl)-N-(2,4-difluorophenyl)-2-methoxypyridine-3-sulfonamide " Suppliers

China 26 United States 1 Global 27
ZHIWE CHEMTECH CO LTD
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021-20221225 13917446399
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AN PharmaTech Co Ltd
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86(21)68097365
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86(21)33321566
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136
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Amadis Chemical Company Limited
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571-89925085
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0086-571-89925065
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Beijing Jin Ming Biotechnology Co., Ltd.
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Shanghai Resuperpharmtech Co., Ltd.
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02150565560; 17321237488
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kevin@resuperpharmtech.com
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China
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Heze Development Zone chuangli Chemical Co., Ltd.
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0530-+86-530-529 6766，+86-15666160102 15666160102
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0530-529 6766
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Shanghai Biopharmaleader Co., Ltd.
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+86 18721201413
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+86 (21) 5775-8967
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China
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Shaanxi Jiandu Pharmaceutical Chemical Co. Ltd.
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029-88380327 17691182729
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029-88380327
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1018@dideu.com
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View Lastest Price from "5-(2-amino-4-oxo-3-(2-(trifluoromethyl)phenyl)-3,4-dihydroquinazolin-6-yl)-N-(2,4-difluorophenyl)-2-methoxypyridine-3-sulfonamide " manufacturers

Career Henan Chemical Co
Product
5-(2-AMINO-4-OXO-3-(2-(TRIFLUOROMETHYL)PHENYL)-3,4-DIHYDROQUINAZOLIN-6-YL)-N-(2,4-DIFLUOROPHENYL)-2-METHOXYPYRIDINE-3-SULFONAMIDE 1384097-27-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%HPLC
Supply Ability
200KG
Release date
2020-02-01

1384097-27-1, "5-(2-amino-4-oxo-3-(2-(trifluoromethyl)phenyl)-3,4-dihydroquinazolin-6-yl)-N-(2,4-difluorophenyl)-2-methoxypyridine-3-sulfonamide "Related Search:


  • "5-(2-amino-4-oxo-3-(2-(trifluoromethyl)phenyl)-3,4-dihydroquinazolin-6-yl)-N-(2,4-difluorophenyl)-2-methoxypyridine-3-sulfonamide "
  • 3-Pyridinesulfonamide, 5-[(3S)-2-amino-3,4-dihydro-4-oxo-3-[2-(trifluoromethyl)phenyl]-6-quinazolinyl]-N-(2,4-difluorophenyl)-2-methoxy-
  • 5-(2-AMINO-4-OXO-3-(2-(TRIFLUOROMETHYL)PHENYL)-3,4-DIHYDROQUIZOLIN-6-YL)-N-(2,4-DIFLUOROPHENYL)-2-METHOXYPYRIDINE-3-SULFOMIDE
  • (3S)-GSK-F1
  • (3S)-GSK-F1, 10 mM in DMSO
  • 1384097-27-1