TY-52156

Product Name: TY-52156
CAS No.: 934369-14-9
Chemical Name: TY-52156
Synonyms: TY-52156;TY52156;TY 52156;N,N'-bis(4-Chlorophenyl)-3,3-dimethyl-2-oxobutanimidhydrazide;N,N'-bis(4-Chlorophenyl)-3,3-dimethyl-2-oxobutanimidhydrazide;N'-(4-chloroanilino)-N-(4-chlorophenyl)-3,3-dimethyl-2-oxo-butanamidine;N-(4-chlorophenyl)-N'-(4-chlorophenylamino)-3,3-dimethyl-2-oxobutanamidine;N-(4-Chlorophenyl)-3,3-dimethyl-2-oxobutanimidic 2-(4-chlorophenyl) hydrazide;N'-(4-chlorophenyl)-N-[(4-chlorophenyl)amino]-3,3-dimethyl-2-oxobutanimidamide;Inhibitor,LPL Receptor,TY-52156,inhibit,Lysophospholipid Receptor,TY 52156,TY52156;Butanimidic acid, N-(4-chlorophenyl)-3,3-dimethyl-2-oxo-, 2-(4-chlorophenyl)hydrazide
CBNumber: CB73122351
Molecular Formula: C18H19Cl2N3O
Formula Weight: 364.27
MOL File: 934369-14-9.mol

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TY-52156 Property

Melting point:: 90-91 °C
Boiling point:: 62-69 °C(Press: 20 Torr)
Density: 1.22±0.1 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: ≥92.8 mg/mL in DMSO; ≥94.6 mg/mL in EtOH; insoluble in H2O
form: crystalline solid
pka: 0.99±0.50(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2499
Product name: TY-52156
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $115
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2499
Product name: TY-52156
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $462
Updated: 2024/03/01

Cayman Chemical

Product number: 19119
Product name: TY 52156
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 19119
Product name: TY 52156
Purity: ≥98%
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 19119
Product name: TY 52156
Purity: ≥98%
Packaging: 10mg
Price: $184
Updated: 2024/03/01

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TY-52156 Chemical Properties,Usage,Production

Uses

TY 52156 is a sphingosine-1-phosphate receptor subtype 3 (S1PR3) antagonist, which is used for the treatment of lung cancer.

Definition

ChEBI: TY 52156 is an imidohydrazide resulting from the formal condensation of the hydrazide carbonyl group of N'-(p-chlorophenyl)-3,3-dimethyl-2-oxobutanehydrazide with the amino group of p-chloroaniline. A potent and selective antagonist of sphingosine-1-phosphate receptor 3 (S1PR3). It has a role as a sphingosine-1-phosphate receptor 3 antagonist. It is a member of monochlorobenzenes and an imidohydrazide.

Biological Activity

ty 52156 (1-(4-chlorophenylhydrazono)-1-(4-chlorophenylamino)-3,3-dimethyl-2-butanone) is a novel s1p3 receptor antagonist [1].sphingosine 1-phosphate (s1p) is a bioactive lysophospholipid mediator mainly released from activated platelets and implicated in many biological responses, such as angiogenesis, vascular development, and cardiovascular function [1].

in vitro

ty-52156 preferentially inhibited the s1p-induced increase in [ca2+]i in s1p3-cho cells. ty-52156 competitively inhibited the dose-dependent [ca2+]i increase elicited by s1p in s1p3-cho with the ki value of ～110 nm for s1p3 receptor. ty-52156 showed submicromolar potency and a high degree of selectivity for s1p3 receptor. ty-52156 (10 μm) inhihbited 24 gpcrs and three ion channels by 〈 30%. s1p dose-dependently decreased cf (coronary flow) in perfused rat heart. s1p dose-dependently induced vasoconstriction in isolated canine cerebral arteries. in hcasmcs, ty-52156 inhibited s1p-induced rho activation.

in vivo

in sd rats, oral bioavailability of ty-52156 was ～70.9%. in rats, pretreatment with ty-52156 significantly attenuated fty-720-induced bradycardia, a broad agonist of s1p receptors. pretreatment with ty-52156 prevented the fty-720-p-induced increase in [ca2+]i in a dose-dependent manner.

storage

Store at -20°C

References

[1] murakami a, takasugi h, ohnuma s, et al. sphingosine 1-phosphate (s1p) regulates vascular contraction via s1p3 receptor: investigation based on a new s1p3 receptor antagonist[j]. molecular pharmacology, 2010, 77(4): 704-713.

TY-52156 Preparation Products And Raw materials

Raw materials

Preparation Products

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TY-52156 Suppliers

China 49 United Kingdom 1 United States 10 Global 60

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934369-14-9, TY-52156Related Search:

TY-52156

N-(4-chlorophenyl)-N'-(4-chlorophenylamino)-3,3-dimethyl-2-oxobutanamidine

TY52156;TY 52156

N-(4-Chlorophenyl)-3,3-dimethyl-2-oxobutanimidic 2-(4-chlorophenyl) hydrazide

Butanimidic acid, N-(4-chlorophenyl)-3,3-dimethyl-2-oxo-, 2-(4-chlorophenyl)hydrazide

N'-(4-chloroanilino)-N-(4-chlorophenyl)-3,3-dimethyl-2-oxo-butanamidine

N,N'-bis(4-Chlorophenyl)-3,3-dimethyl-2-oxobutanimidhydrazide

Inhibitor,LPL Receptor,TY-52156,inhibit,Lysophospholipid Receptor,TY 52156,TY52156

N,N'-bis(4-Chlorophenyl)-3,3-dimethyl-2-oxobutanimidhydrazide

N'-(4-chlorophenyl)-N-[(4-chlorophenyl)amino]-3,3-dimethyl-2-oxobutanimidamide

934369-14-9