ChemicalBook > CAS DataBase List > Amgen IRE1α Inhibitor
Amgen IRE1α Inhibitor
- Product Name
- Amgen IRE1α Inhibitor
- CAS No.
- 1630086-20-2
- Chemical Name
- Amgen IRE1α Inhibitor
- Synonyms
- Kira8;KIRA8 (AMG-18);IRE-1 INHIBITOR;Kira8, 10 mM in DMSO;Amgen IRE1α Inhibitor;Amgen IRE1a Inhibitor;Inositol requiring enzyme 1,inhibit,AMG18,AMG 18,Kira 8,Kira8,Inhibitor,IRE1,Kira-8;(S)-2-Chloro-N-[6-methyl-5-[[3-[2-(3-piperidylamino)-4-pyrimidinyl]-2-pyridyl]oxy]-1-naphthyl]benzenesulfonamide;(S)-2-Chloro-N-(6-methyl-5-((3-(2-(piperidin-3-ylamino)pyrimidin-4-yl)pyridin-2-yl)oxy)naphthalen-1-yl)benzenesulfonamide;Benzenesulfonamide, 2-chloro-N-[6-methyl-5-[[3-[2-[(3S)-3-piperidinylamino]-4-pyrimidinyl]-2-pyridinyl]oxy]-1-naphthalenyl]-
- CBNumber
- CB73123772
- Molecular Formula
- C31H29ClN6O3S
- Formula Weight
- 601.12
- MOL File
- 1630086-20-2.mol
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Amgen IRE1α Inhibitor Property
- Boiling point:
- 812.6±75.0 °C(Predicted)
- Density
- 1.383±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Water:30.0(Max Conc. mg/mL);49.91(Max Conc. mM)
- form
- Solid
- pka
- 7.66±0.30(Predicted)
- color
- Light yellow to yellow
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N-Bromosuccinimide Price
TRC
- Product number
- A576530
- Product name
- AmgenIRE1αInhibitor
- Packaging
- 10mg
- Price
- $1320
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0084229
- Product name
- Kira8
- Purity
- 99.74%
- Packaging
- 5mg
- Price
- $320
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0084229
- Product name
- Kira8
- Purity
- 99.74%
- Packaging
- 10mg
- Price
- $520
- Updated
- 2021/12/16
Crysdot
- Product number
- CD11242815
- Product name
- (S)-2-Chloro-N-(6-methyl-5-((3-(2-(piperidin-3-ylamino)pyrimidin-4-yl)pyridin-2-yl)oxy)naphthalen-1-yl)benzenesulfonamide
- Purity
- 97%
- Packaging
- 5mg
- Price
- $689
- Updated
- 2021/12/16
Chemenu
- Product number
- CM268504
- Product name
- (S)-2-Chloro-N-(6-methyl-5-((3-(2-(piperidin-3-ylamino)pyrimidin-4-yl)pyridin-2-yl)oxy)naphthalen-1-yl)benzenesulfonamide
- Purity
- 97%
- Packaging
- 10mg
- Price
- $977
- Updated
- 2021/12/16
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Amgen IRE1α Inhibitor Chemical Properties,Usage,Production
Uses
Amgen IRE1α Inhibitor is an inhibitor of IRE1α. IRE1α is a sensor of unfolded protein accumulation that triggers the unfolded protein response.
Biological Activity
KIRA8 is an ATP-competitive, potent and selective IRE1α kinase inhibitor (IRE1α/β Ki = 2/120 nM) th at attenuates IRE1α endonuclease activity (IRE1α/β IC50 = 5/55 nM) with good kinome selectivity. KIRA8 inhibits thapsigargin-induced UPR (IC50 = 99 nM; HT1080 XBP1-Luc cells) and shows therapeutic efficacy in murine models of type 1 diabetes (T1D), pulmonary fibrosis, multiple myeloma (MM), and pancreatic neuroendocrine tumors (PanNET) in vivo (30-50 mg/kg/day i.p.).
Amgen IRE1α Inhibitor Preparation Products And Raw materials
Raw materials
Preparation Products
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