ChemicalBook > CAS DataBase List > Acid Ceramidase Inhibitor 17a

Acid Ceramidase Inhibitor 17a

Product Name
Acid Ceramidase Inhibitor 17a
CAS No.
1644158-57-5
Chemical Name
Acid Ceramidase Inhibitor 17a
Synonyms
ARN14974;ARN14974, 10 mM in DMSO;Acid Ceramidase Inhibitor 17a;Acid Ceramidase Inhibitor IV, BOC;3(2H)-Benzoxazolecarboxamide, 6-(4-fluorophenyl)-2-oxo-N-(4-phenylbutyl)-;6-(4-Fluorophenyl)-2-oxo-N-(4-phenylbutyl)benzo[d]oxazole-3(2H)-carboxamide;6-(4-Fluorophenyl)-2-oxo-N-(4-phenylbutyl)-1,3-benzoxazole-3(2H)-carboxamide;6-(4-fluorophenyl)-2-oxo-N-(4-phenylbutyl)-2,3-dihydro-1,3-benzoxazole-3-carboxamide;benzoxazolone,signaling,Inhibitor,inhibit,Ceramidase,ARN 14974,ceramide-mediated,carboxamide,ARN14974,sphingosine,ARN-14974,dysfunctional
CBNumber
CB73124052
Molecular Formula
C24H21FN2O3
Formula Weight
404.434
MOL File
1644158-57-5.mol
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Acid Ceramidase Inhibitor 17a Property

Density 
1.276±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMF: 2 mg/ml; DMSO: 2 mg/ml
form 
A crystalline solid
pka
11.14±0.20(Predicted)
color 
Off-white to pink
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Safety

WGK Germany 
WGK 3
Storage Class
11 - Combustible Solids
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
5.33371
Product name
Acid Ceramidase Inhibitor IV, BOC
Packaging
10 mg
Price
$204
Updated
2025/07/31
Cayman Chemical
Product number
17119
Product name
ARN14974
Purity
≥98%
Packaging
1mg
Price
$27
Updated
2024/03/01
Cayman Chemical
Product number
17119
Product name
ARN14974
Purity
≥98%
Packaging
5mg
Price
$122
Updated
2024/03/01
Cayman Chemical
Product number
17119
Product name
ARN14974
Purity
≥98%
Packaging
10mg
Price
$189
Updated
2024/03/01
Cayman Chemical
Product number
17119
Product name
ARN14974
Purity
≥98%
Packaging
25mg
Price
$439
Updated
2024/03/01
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Acid Ceramidase Inhibitor 17a Chemical Properties,Usage,Production

Uses

Acid Ceramidase Inhibitor 17a is a benzoxazolone carboxamide that potently inhibits acid cerimidase.

Biological Activity

Cell permeable: yes', 'Primary Target
Acid ceramidase', 'Reversible: no', 'Target IC50: 79 nM against HEK293 lysosomal lysate AC activity

in vivo

ARN14974 (10 mg/kg; i.p.; mice) causes a substantial reduction in AC activity in multiple organs, including brain, liver, heart, lungs, and kidney[1].
ARN14974 (10 mg/kg; i.p.) quickly enters the bloodstream after a single intraperitoneal administration in mice, reaching a maximal plasma concentration, Cmax, of 1767.9 ng/mL and displaying a half-life time of 458 min in circulation. ARN14974 (1 mg/kg; i.v.) shows a Cmax and a half-life time of 628 ng/mL and 72 min, respectively[1].

Acid Ceramidase Inhibitor 17a Preparation Products And Raw materials

Raw materials

Preparation Products

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Acid Ceramidase Inhibitor 17a Suppliers

China 44 India 1 United States 7 Global 52
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
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12952
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Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4800
Advantage
55
Shanghai Beckham Medical Technology Co., Ltd
Tel
13816613772
Fax
QQ: 12922499
Email
huahero21@sina.com
Country
China
ProdList
2495
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Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
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ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
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Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9531
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Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
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Chengdu Saint - Kay Biotechnology Co., Ltd.
Tel
028-85157043 15882256948
Email
676046971@qq.com
Country
China
ProdList
4183
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Tianjin Kaifu Pharmaceutical Technology Co., Ltd.
Tel
18081075745
Email
chemflowtech@sina.com
Country
China
ProdList
1886
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TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32470
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58

1644158-57-5, Acid Ceramidase Inhibitor 17aRelated Search:


  • Acid Ceramidase Inhibitor 17a
  • ARN14974
  • 6-(4-Fluorophenyl)-2-oxo-N-(4-phenylbutyl)-1,3-benzoxazole-3(2H)-carboxamide
  • benzoxazolone,signaling,Inhibitor,inhibit,Ceramidase,ARN 14974,ceramide-mediated,carboxamide,ARN14974,sphingosine,ARN-14974,dysfunctional
  • 3(2H)-Benzoxazolecarboxamide, 6-(4-fluorophenyl)-2-oxo-N-(4-phenylbutyl)-
  • 6-(4-fluorophenyl)-2-oxo-N-(4-phenylbutyl)-2,3-dihydro-1,3-benzoxazole-3-carboxamide
  • ARN14974, 10 mM in DMSO
  • Acid Ceramidase Inhibitor IV, BOC
  • 6-(4-Fluorophenyl)-2-oxo-N-(4-phenylbutyl)benzo[d]oxazole-3(2H)-carboxamide
  • 1644158-57-5