ChemicalBook > CAS DataBase List > Ezutromid

Ezutromid

Uses

Product Name: Ezutromid
CAS No.: 945531-77-1
Chemical Name: Ezutromid
Synonyms: CS-2334;BMN-195;SMT C1100;Ezutromid;VOX-C1100;VOX C1100;Ezutromid, 10 mM in DMSO;Ezutromid (BMN-195, SMTC-1100);5-(Ethylsulfonyl)-2-(2-naphthalenyl)benzoxazole;Benzoxazole, 5-(ethylsulfonyl)-2-(2-naphthalenyl)-
CBNumber: CB73133346
Molecular Formula: C19H15NO3S
Formula Weight: 337.39
MOL File: 945531-77-1.mol

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Ezutromid Property

storage temp.: Store at -20°C
solubility: DMSO:6.5(Max Conc. mg/mL);19.27(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.89(Max Conc. mM)
DMF:2.0(Max Conc. mg/mL);5.93(Max Conc. mM)
form: A crystalline solid
color: Light yellow to yellow
InChI: InChI=1S/C19H15NO3S/c1-2-24(21,22)16-9-10-18-17(12-16)20-19(23-18)15-8-7-13-5-3-4-6-14(13)11-15/h3-12H,2H2,1H3
InChIKey: KSGCNXAZROJSNW-UHFFFAOYSA-N
SMILES: O1C2=CC=C(S(CC)(=O)=O)C=C2N=C1C1=CC=C2C(=C1)C=CC=C2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 20309
Product name: Ezutromid
Purity: ≥98%
Packaging: 1mg
Price: $33
Updated: 2024/03/01

Cayman Chemical

Product number: 20309
Product name: Ezutromid
Purity: ≥98%
Packaging: 5mg
Price: $143
Updated: 2024/03/01

Cayman Chemical

Product number: 20309
Product name: Ezutromid
Purity: ≥98%
Packaging: 10mg
Price: $254
Updated: 2024/03/01

Cayman Chemical

Product number: 20309
Product name: Ezutromid
Purity: ≥98%
Packaging: 25mg
Price: $553
Updated: 2024/03/01

AK Scientific

Product number: 2805DC
Product name: Ezutromid
Packaging: 5mg
Price: $257
Updated: 2021/12/16

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Ezutromid Chemical Properties,Usage,Production

Uses

5-(Ethylsulfonyl)-2-(naphthalen-2-yl)benzo[D] oxazole is a useful research chemical compound.

Uses

Ezutromid (SMT C1100) is a first-in-class, orally active benzoxazole utrophin modulator with an EC50 of 0.91 μM. Ezutromid can be used for the research Duchenne muscular dystrophy (DMD). Ezutromid inhibits CYP1A2 enzymic activity in human liver microsomes (HLM) with an IC50 of 5.4 μM[1][2].

in vivo

Note: You can dissolve the products in phosphate buffered saline (PBS), 0.1% Tween-20, 5% DMSO)

IC 50

CYP1

References

[1] Chancellor DR, et al. Discovery of 2-arylbenzoxazoles as upregulators of utrophin production for the treatment of Duchenne muscular dystrophy. J Med Chem. 2011;54(9):3241-3250. DOI:10.1021/jm200135z
[2] Chatzopoulou M, et al. Isolation, Structural Identification, Synthesis, and Pharmacological Profiling of 1,2-trans-Dihydro-1,2-diol Metabolites of the Utrophin Modulator Ezutromid. J Med Chem. 2020;63(5):2547-2556. DOI:10.1021/acs.jmedchem.9b01547
[3] Tinsley JM et al. Daily treatment with SMTC1100, a novel small molecule utrophin upregulator, dramatically reduces the dystrophic symptoms in the mdx mouse. PLoS One. 2011 May 6;6(5):e19189. DOI:10.1371/journal.pone.0019189
[4] Tinsley J et al. Safety, tolerability, and pharmacokinetics of SMT C1100, a 2-arylbenzoxazole utrophin modulator, following single- and multiple-dose administration to healthy male adult volunteers. J Clin Pharmacol. 2015 Jun;55(6):698-707. DOI:10.1002/jcph.468
[5] Guiraud S et al. Second-generation compound for the modulation of utrophin in the therapy of DMD. Hum Mol Genet. 2015 Aug 1;24(15):4212-24. DOI:10.1093/hmg/ddv154

Ezutromid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ezutromid manufacturers

Career Henan Chemical Co

Product: Ezutromid 945531-77-1
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-12

945531-77-1, EzutromidRelated Search:

Ezetimibe Trimebutine

Ezutromid

SMT C1100

BMN-195

CS-2334

SMT C1100; VOX C1100; BMN 195; SMT-C1100; VOX-C1100; BMN-195; BMN195

VOX C1100

VOX-C1100

Benzoxazole, 5-(ethylsulfonyl)-2-(2-naphthalenyl)-

5-(Ethylsulfonyl)-2-(naphthalen-2-yl)benzo[D] oxazole

Ezutromid (BMN-195, SMTC-1100)

SMT C-1100,SMT C 1100,Inhibitor,dystrophy,benzoxazole,BMN-195,inhibit,microsomes,BMN195,Ezutromid,liver,muscular,Duchenne,metabolite

Ezutromid, 10 mM in DMSO

5-(Ethylsulfonyl)-2-(2-naphthalenyl)benzoxazole

945531-77-1

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