Mito-TEMPO
- Product Name
- Mito-TEMPO
- CAS No.
- 1569257-94-8
- Chemical Name
- Mito-TEMPO
- Synonyms
- Mito-TEMPO (hydrate);2,2,6,6-tetramethyl-4-[[2-(triphenylphosphonio)acetyl]amino]-1-piperidinyloxy,monochloride,monohydrate;[2-[(1-$l^{1}-oxidanyl-2,2,6,6-tetramethylpiperidin-4-yl)amino]-2-oxoethyl]-triphenylphosphanium:chloride:hydrate
- CBNumber
- CB73136756
- Molecular Formula
- C29H37ClN2O3P*
- Formula Weight
- 528.042
- MOL File
- 1569257-94-8.mol
Mito-TEMPO Property
- storage temp.
- Store at -20°C
- solubility
- DMF: 15 mg/ml; DMSO: 10 mg/ml; Ethanol: 15 mg/ml; PBS (pH 7.2): 5 mg/ml
- form
- A crystalline solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 16621
- Product name
- Mito-TEMPO (hydrate)
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 16621
- Product name
- Mito-TEMPO (hydrate)
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $70
- Updated
- 2024/03/01
- Product number
- 16621
- Product name
- Mito-TEMPO (hydrate)
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $120
- Updated
- 2024/03/01
- Product number
- 16621
- Product name
- Mito-TEMPO (hydrate)
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $267
- Updated
- 2024/03/01
- Product number
- 6732DW
- Product name
- CID73504624
- Packaging
- 1mg
- Price
- $133
- Updated
- 2021/12/16
Mito-TEMPO Chemical Properties,Usage,Production
Description
MitoTEMPO is a mitochondria-targeted superoxide dismutase mimetic that possesses superoxide and alkyl radical scavenging properties.1 This compound combines the antioxidant piperidine nitroxide TEMPO with the lipophilic cation triphenylphosphonium, which allows it to pass through lipid bilayers and accumulate in mitochondria.1 Mitochondrial targeting of superoxide scavenging via mitoTEMPO has been examined for potential therapeutic benefit to a variety of mitochondrial dysfunctions arising from excessive reactive oxygen species.2,3,4
References
1. Dikalov, S. Cross talk between mitochondria and NADPH oxidases Free Radic. Biol. Med. 51(7),1289-1301(2011).
2. Liang, H.L., Arsenault, J., Mortensen, J., et al. Partial attenuation of cytotoxicity and apoptosis by SOD1 in ischemic renal epithelial cells Apoptosis 14(10),1176-1189(2009).
3. Dikalova, A.E., Bikineyeva, A.T., Budzyn, K., et al. Therapeutic targeting of mitochondrial superoxide in hypertension Circ. Res. 107(1),106-116(2010).
4. Liang, H.L., Sedlic, F., Bosnjak, Z., et al. SOD1 and MitoTEMPO partially prevent mitochondrial permeability transition pore opening, necrosis, and mitochondrial apoptosis after ATP depletion recovery Free Radic. Biol. Med. 49(10),1550-1560(2010).
Mito-TEMPO Preparation Products And Raw materials
Raw materials
Preparation Products
Mito-TEMPO Suppliers
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32161
- Advantage
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- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
- 57505
- Advantage
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- Tel
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- --
- cayman@caymanchem.com
- Country
- United States
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