ChemicalBook > CAS DataBase List > 4-((N-benzyl-8-chloro-1-methyl-1,4-dihydrochromeno[4,3-c]pyrazole-3-carboxamido)methyl)benzoicacid

4-((N-benzyl-8-chloro-1-methyl-1,4-dihydrochromeno[4,3-c]pyrazole-3-carboxamido)methyl)benzoicacid

Product Name
4-((N-benzyl-8-chloro-1-methyl-1,4-dihydrochromeno[4,3-c]pyrazole-3-carboxamido)methyl)benzoicacid
CAS No.
1773489-72-7
Chemical Name
4-((N-benzyl-8-chloro-1-methyl-1,4-dihydrochromeno[4,3-c]pyrazole-3-carboxamido)methyl)benzoicacid
Synonyms
CS-2689;LMB-763;EOS-61760;Nidufexor;Nidufexor(LMB-763);(Nidufexor)EOS-61760;Nidufexor, 10 mM in DMSO;inhibit,Inhibitor,Autophagy,NR1H4,FXR,Nidufexor,LMB-763,LMB763,LMB 763;4-((N-benzyl-8-chloro-1-methyl-1,4-dihydrochromeno[4,3-c]pyrazole-3-carboxamido)methyl)benzoicacid;Benzoic acid, 4-[[[(8-chloro-1,4-dihydro-1-methyl[1]benzopyrano[4,3-c]pyrazol-3-yl)carbonyl](phenylmethyl)amino]methyl]-
CBNumber
CB73142726
Molecular Formula
C27H22ClN3O4
Formula Weight
487.93
MOL File
1773489-72-7.mol
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4-((N-benzyl-8-chloro-1-methyl-1,4-dihydrochromeno[4,3-c]pyrazole-3-carboxamido)methyl)benzoicacid Property

Boiling point:
781.1±60.0 °C(Predicted)
Density 
1.36±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: soluble; Ethanol: soluble
form 
A solid
pka
4.17±0.10(Predicted)
color 
White to off-white
InChIKey
JYTIXGYXBIBOMN-UHFFFAOYSA-N
SMILES
C(O)(=O)C1=CC=C(CN(C(C2=NN(C)C3C4=CC(Cl)=CC=C4OCC=32)=O)CC2=CC=CC=C2)C=C1
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0039398
Product name
Nidufexor
Purity
98.96%
Packaging
5mg
Price
$150
Updated
2021/12/16
ChemScene
Product number
CS-0039398
Product name
Nidufexor
Purity
98.96%
Packaging
10mg
Price
$250
Updated
2021/12/16
ChemScene
Product number
CS-0039398
Product name
Nidufexor
Purity
98.96%
Packaging
50mg
Price
$750
Updated
2021/12/16
ChemScene
Product number
CS-0039398
Product name
Nidufexor
Purity
98.96%
Packaging
100mg
Price
$1350
Updated
2021/12/16
DC Chemicals
Product number
DC21243
Product name
Nidufexor（LMB-763）
Purity
>98%
Packaging
250mg
Price
$1700
Updated
2021/12/16
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4-((N-benzyl-8-chloro-1-methyl-1,4-dihydrochromeno[4,3-c]pyrazole-3-carboxamido)methyl)benzoicacid Chemical Properties,Usage,Production

Uses

Nidufexor (LMB763) is an orally-available farnesoid X receptor (FXR) agonist for the research of nonalcoholic steatohepatitis (NASH)[1].

in vivo

Nidufexor (LMB763) is a potent and specific FXR-gene modulator in vivo, reducing steatosis, inflammation and fibrosis in nonalcoholic steatohepatitis (NASH) murine models[1].
? Nidufexor exhibits moderate Cmax (4.5, 12.4, 28.1, 80.9, and 140.8 μM) and terminal elimination half-lives (t1/2; 3.9 5.7 6.3 5.6 6.3 h) following oral administration (3 ,10 ,30, 100, and 300mg/kg) in adult male Wistar Han rats (age approximately 10 weeks)[1]
? Nidufexor exhibits terminal elimination half-lives (mouse 4.5, rat 4.4 and, dog 6.8 h) following intravenous administration (mouse 3.0, rat 5.0 and, dog 0.5 mg/kg)[1].
? Nidufexor exhibits terminal elimination half-lives (mouse 3.5, rat 2.7 and, dog 10.1 h) following oral administration (mouse 10, rat 10 and, dog 2 mg/kg)[1].

Animal Model:Han-Wistar rats[1]
Dosage:0.1, 0.3, 1.5, 7.5, 25, 100 mg/kg (Pharmacokinetic Analysis)
Administration:Oral gavage, once daily for 14 days
Result:On day 1 and 13, serum exposure increased approximately dose-proportionally from 0.1 to 100 mg/kg. Exposure at 0.1 and 0.3 mg/kg was likely underestimated on day 13. No significant accumulation was observed[1].

References

[1] Chianelli D, et al. Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis. J Med Chem. 2020 Apr 23;63(8):3868-3880. DOI:10.1021/acs.jmedchem.9b01621

4-((N-benzyl-8-chloro-1-methyl-1,4-dihydrochromeno[4,3-c]pyrazole-3-carboxamido)methyl)benzoicacid Preparation Products And Raw materials

Raw materials

Preparation Products

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4-((N-benzyl-8-chloro-1-methyl-1,4-dihydrochromeno[4,3-c]pyrazole-3-carboxamido)methyl)benzoicacid Suppliers

China 73 United States 6 Global 79
Fujian boshi pharmaceutical technology co. LTD
Tel
0595-22008920; 18120708884
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393612455@qq.com
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China
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255
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58
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
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isunpharm@qq.com
Country
China
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4720
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55
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4768
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55
Shanghaizehan biopharma technology co., Ltd.
Tel
021-61350663 13052117465
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021-61350662
Email
sales@zehanbiopharma.com
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China
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984
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Struchem Co., Ltd.
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0512-63009836 18994340901
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0512-63006936
Email
helen@struchem.com
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China
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3981
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60
Shanghai Beckham Medical Technology Co., Ltd
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13816613772
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QQ: 12922499
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huahero21@sina.com
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China
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55
Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
Fax
021-65675885
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info@efebio.com
Country
China
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ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
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62
Jinan elephant international trading co., LTD
Tel
Fax
-
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13006575422@163.com
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China
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6355
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Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136
Fax
21-5161 9052
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Sales@ATKchemical.com
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China
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9125
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1773489-72-7, 4-((N-benzyl-8-chloro-1-methyl-1,4-dihydrochromeno[4,3-c]pyrazole-3-carboxamido)methyl)benzoicacidRelated Search:


  • 4-((N-benzyl-8-chloro-1-methyl-1,4-dihydrochromeno[4,3-c]pyrazole-3-carboxamido)methyl)benzoicacid
  • EOS-61760
  • (Nidufexor)EOS-61760
  • Nidufexor(LMB-763)
  • Nidufexor
  • LMB-763
  • CS-2689
  • Benzoic acid, 4-[[[(8-chloro-1,4-dihydro-1-methyl[1]benzopyrano[4,3-c]pyrazol-3-yl)carbonyl](phenylmethyl)amino]methyl]-
  • inhibit,Inhibitor,Autophagy,NR1H4,FXR,Nidufexor,LMB-763,LMB763,LMB 763
  • Nidufexor, 10 mM in DMSO
  • 1773489-72-7