ChemicalBook > CAS DataBase List > GNE-495

GNE-495

Product Name
GNE-495
CAS No.
1449277-10-4
Chemical Name
GNE-495
Synonyms
GNE-495;GNE-495;GNE 495;GNE495;MAPK Kinase Kinase Kinase,MAP4K,inhibit,GNE-495,GNE 495,GNE495,Inhibitor;8-Amino-N-[1-(cyclopropylcarbonyl)-3-azetidinyl]-2-(3-fluorophenyl)-1,7-naphthyridine-5-carboxamide;8-amino-N-(1-(cyclopropanecarbonyl)azetidin-3-yl)-2-(3-fluorophenyl)-1,7-naphthyridine-5-carboxamide;1,7-Naphthyridine-5-carboxamide, 8-amino-N-[1-(cyclopropylcarbonyl)-3-azetidinyl]-2-(3-fluorophenyl)-
CBNumber
CB73144856
Molecular Formula
C22H20FN5O2
Formula Weight
405.42
MOL File
1449277-10-4.mol
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GNE-495 Property

Boiling point:
734.5±60.0 °C(Predicted)
Density 
1.45±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:3.59(Max Conc. mg/mL);8.85(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:7):0.125(Max Conc. mg/mL);0.31(Max Conc. mM)
DMF:5.0(Max Conc. mg/mL);12.33(Max Conc. mM)
Water:1.0(Max Conc. mg/mL);2.47(Max Conc. mM)
form 
A crystalline solid
pka
11.60±0.20(Predicted)
color 
Light yellow to yellow
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P330Rinse mouth.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21808
Product name
GNE-495
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
21808
Product name
GNE-495
Purity
≥98%
Packaging
5mg
Price
$193
Updated
2024/03/01
Cayman Chemical
Product number
21808
Product name
GNE-495
Purity
≥98%
Packaging
10mg
Price
$321
Updated
2024/03/01
Cayman Chemical
Product number
21808
Product name
GNE-495
Purity
≥98%
Packaging
25mg
Price
$533
Updated
2024/03/01
ChemScene
Product number
CS-5957
Product name
GNE-495
Purity
99.68%
Packaging
1mg
Price
$80
Updated
2021/12/16
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GNE-495 Chemical Properties,Usage,Production

Uses

GNE-495 is a potent and selective MAP4K4 inhibitor with an IC50 of 3.7 nM.

in vivo

GNE-495 is administered intraperitoneally to neonatal mouse pups at high doses: 25 and 50 mg/kg. GNE-495 shows good in vivo profile in all species tested, with low clearances, moderate terminal half-lives, and reasonable oral exposure levels (F=37-47%)[1].

IC 50

MAP4K4: 3.7 nM (IC50)

References

[1] Ndubaku CO et al. Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis. ACS Med Chem Lett. 2015 Jun 29;6(8):913-8. DOI:10.1021/acsmedchemlett.5b00174

GNE-495 Preparation Products And Raw materials

Raw materials

Preparation Products

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GNE-495 Suppliers

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1449277-10-4, GNE-495Related Search:


  • GNE-495
  • 8-Amino-N-[1-(cyclopropylcarbonyl)-3-azetidinyl]-2-(3-fluorophenyl)-1,7-naphthyridine-5-carboxamide
  • 8-amino-N-(1-(cyclopropanecarbonyl)azetidin-3-yl)-2-(3-fluorophenyl)-1,7-naphthyridine-5-carboxamide
  • GNE-495;GNE 495;GNE495
  • 1,7-Naphthyridine-5-carboxamide, 8-amino-N-[1-(cyclopropylcarbonyl)-3-azetidinyl]-2-(3-fluorophenyl)-
  • MAPK Kinase Kinase Kinase,MAP4K,inhibit,GNE-495,GNE 495,GNE495,Inhibitor
  • 1449277-10-4
  • GNE-495