ChemicalBook > CAS DataBase List > Sephin 1
Sephin 1
- Product Name
- Sephin 1
- CAS No.
- 951441-04-6
- Chemical Name
- Sephin 1
- Synonyms
- Sephin 1;Icerguastat;lcerguastat;Sephin 1 - NSC 65390;2-[(E)-(2-chlorophenyl)methylideneamino]guanidine;(E)-2-(2-Chlorobenzylidene)hydrazinecarboximidamide;Hydrazinecarboximidamide, 2-[(2-chlorophenyl)methylene]-, (2E)-;IFB 088,Sephin1,Inhibitor,misfolding,Sephin-1,prion,Icerguastat,IFB088,stress,eIF2α,sclerosis,Phosphatase,inhibit,protein
- CBNumber
- CB73146380
- Molecular Formula
- C8H9ClN4
- Formula Weight
- 196.64
- MOL File
- 951441-04-6.mol
More
Less
Sephin 1 Property
- Boiling point:
- 320.9±44.0 °C(Predicted)
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Soluble in DMSO (100 mM)
- form
- powder
- pka
- 8.74±0.30(Predicted)
- color
- white to beige
More
Less
Safety
- RIDADR
- UN 2811 6.1 / PGIII
More
Less
More
Less
N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML1356
- Product name
- Sephin1
- Purity
- ≥95% (HPLC)
- Packaging
- 10MG
- Price
- $69
- Updated
- 2023/06/20
Tocris
- Product number
- 5553
- Product name
- Sephin1
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $616
- Updated
- 2021/12/16
Axon Medchem
- Product number
- Axon2524
- Product name
- Sephin1-NSC65390
- Purity
- 99%
- Packaging
- 10mg
- Price
- $60.5
- Updated
- 2021/12/16
More
Less
Sephin 1 Chemical Properties,Usage,Production
Uses
Sephin 1 is a selective inhibitor of holophosphatase, a regulatory subunit of protein phosphatase 1. May be used in the prevention of protein misfolding diseases.
Biochem/physiol Actions
Sephin1 is a selective inhibitor of a holophosphatase. It is a guanabez derivative that binds to and inhibits a regulatory subunit of the stress-induced protein phosphatase 1 (PPP1R15A), but not the constitutive PPP1R15B, and lacks α2-adrenergic activity. Phosphorylation of eIF2α, α subunit of eukaryotic translation initiation factor 2, reduces protein synthesis and prevents the accumulation of misfolded protein in the endoplasmic reticulum (ER). PPP1R15A recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate eIF2α, so inhibiting PPP1R15A activity prolongs the phosphorylation of eIF2α and aids in its prevention of the accumulation of misfolded protein. In vitro Sephin1 protected cells from lethal protein misfolding and cytotoxic ER stress. In vivo sephin1 prevented two unrelated protein misfolding diseases in mice (Charchot-Marie-Tooth 1B and ALS).
storage
+4°C
Sephin 1 Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
Sephin 1 Suppliers
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51456
- Advantage
- 80
- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4566
- Advantage
- 55
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9806
- Advantage
- 58
- Tel
- 15076683720
- Fax
- 022-23754520
- klq@cw-bio.com
- Country
- China
- ProdList
- 4966
- Advantage
- 55
- Tel
- 21-31433387 15618786686
- Fax
- QQ:1369748377
- sales@rechemscience.com
- Country
- China
- ProdList
- 2988
- Advantage
- 58
- Tel
- 021-58447131 13564518121
- sales@dcchemicals.com
- Country
- China
- ProdList
- 9409
- Advantage
- 58
- Tel
- 0519-85788828 13775037613
- sales@chemrenpharm.com
- Country
- China
- ProdList
- 3600
- Advantage
- 58
- Tel
- 15195022192
- 279776773@qq.com
- Country
- China
- ProdList
- 2011
- Advantage
- 58
- Tel
- 15865264761
- 486064515@qq.com
- Country
- China
- ProdList
- 4315
- Advantage
- 58
- Tel
- 18051384581
- sales@chemhifuture.com
- Country
- China
- ProdList
- 2998
- Advantage
- 58
- Tel
- 400-1647117 13681763483
- product02@bidepharm.com
- Country
- China
- ProdList
- 62075
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24644
- Advantage
- 58
- Tel
- 0371-0371-53399770 18037166334
- 2853031800@qq.com
- Country
- China
- ProdList
- 3253
- Advantage
- 58
- Tel
- 13720134139 13720134139
- orders@jknbiochem.com
- Country
- China
- ProdList
- 5821
- Advantage
- 58
- Tel
- 021-61734564
- August@easycdmo.com
- Country
- China
- ProdList
- 10030
- Advantage
- 58
- Tel
- 025-58851786 17714337195
- sales@tybiochem.com
- Country
- China
- ProdList
- 6813
- Advantage
- 58
- Tel
- 021-54306202 18917919676
- info@hanhongsci.com
- Country
- China
- ProdList
- 29979
- Advantage
- 58
- Tel
- 021-59167510 18117107507
- vip@med-life.cn
- Country
- China
- ProdList
- 4997
- Advantage
- 58
- Tel
- 025-85560043 15850508050
- Fax
- 025-85563444
- cindy.huang@synzest.com
- Country
- China
- ProdList
- 12005
- Advantage
- 58
- Tel
- +86-18521732826
- market@aladdin-e.com
- Country
- China
- ProdList
- 48461
- Advantage
- 58
- Tel
- 13823398779 18670069958
- 3062105966@qq.com
- Country
- China
- ProdList
- 3262
- Advantage
- 58
- Tel
- 18024082417
- market@ubiochem.com
- Country
- China
- ProdList
- 9266
- Advantage
- 58
- Tel
- 17316404525
- 209533805@qq.com
- Country
- China
- ProdList
- 9765
- Advantage
- 58
- Tel
- 15764055027
- 15764055027@163.com
- Country
- China
- ProdList
- 534
- Advantage
- 58
- Tel
- 18122215013
- 780229652@qq.com
- Country
- China
- ProdList
- 1163
- Advantage
- 58
- Tel
- 13915962545
- 2881759498@qq.com
- Country
- China
- ProdList
- 3660
- Advantage
- 58
- Tel
- +8613720134139
- orders@jknbiochem.com
- Country
- China
- ProdList
- 5221
- Advantage
- 58
- Tel
- +undefined18051384581
- sales@chemhifuture.com
- Country
- China
- ProdList
- 3135
- Advantage
- 58
- Tel
- --
- Fax
- --
- 1861586486@qq.com
- Country
- CHINA
- ProdList
- 6648
- Advantage
- 58
- Tel
- --
- Fax
- --
- 15810802415@139.com
- Country
- CHINA
- ProdList
- 6750
- Advantage
- 58
- Tel
- --
- Fax
- --
- marketing@4abio.com
- Country
- CHINA
- ProdList
- 6401
- Advantage
- 58
- Tel
- --
- Fax
- --
- 470003480@QQ.COM
- Country
- CHINA
- ProdList
- 6955
- Advantage
- 58
- Tel
- --
- Fax
- --
- market@xlswkj.com
- Country
- CHINA
- ProdList
- 6793
- Advantage
- 58
- Tel
- --
- Fax
- --
- lyn@biopike.com.cn
- Country
- CHINA
- ProdList
- 6629
- Advantage
- 58
- Tel
- --
- Fax
- --
- Country
- CHINA
- ProdList
- 6829
- Advantage
- 58
- Tel
- --
- Fax
- --
- 3007606172@qq.com
- Country
- CHINA
- ProdList
- 6002
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@wheybio.com
- Country
- CHINA
- ProdList
- 4398
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@f-biology.com
- Country
- CHINA
- ProdList
- 6025
- Advantage
- 58
- Tel
- --
- Fax
- --
- 912529879@qq.com
- Country
- CHINA
- ProdList
- 6835
- Advantage
- 58
- Tel
- --
- Fax
- --
- yangmei@bioneeds.net
- Country
- CHINA
- ProdList
- 6999
- Advantage
- 58
- Tel
- --
- Fax
- --
- Country
- CHINA
- ProdList
- 6973
- Advantage
- 58
- Tel
- --
- Fax
- --
- 847627550@qq.com
- Country
- CHINA
- ProdList
- 6087
- Advantage
- 58
- Tel
- --
- Fax
- --
- 471161314@qq.com
- Country
- CHINA
- ProdList
- 6210
- Advantage
- 58
- Tel
- --
- Fax
- --
- 1562893815@qq.com
- Country
- CHINA
- ProdList
- 6936
- Advantage
- 58
- Tel
- --
- Fax
- --
- jskangchina@163.com
- Country
- CHINA
- ProdList
- 4012
- Advantage
- 58
- Tel
- --
- Fax
- --
- chenxue_gz@163.com
- Country
- CHINA
- ProdList
- 6600
- Advantage
- 58
- Tel
- --
- Fax
- --
- shxiyuanbio@163.com
- Country
- CHINA
- ProdList
- 6906
- Advantage
- 58
- Tel
- --
- Fax
- --
- 344843571@qq.com
- Country
- CHINA
- ProdList
- 6318
- Advantage
- 58
- Tel
- --
- Fax
- --
- 1914109725@qq.com
- Country
- CHINA
- ProdList
- 6518
- Advantage
- 58
- Tel
- --
- Fax
- --
- 1985563437@qq.com
- Country
- CHINA
- ProdList
- 6158
- Advantage
- 58