SRI-011381 (hydrochloride)

Product Name: SRI-011381 (hydrochloride)
CAS No.: 2070014-88-7
Chemical Name: SRI-011381 (hydrochloride)
Synonyms: SRI-011381 (hydrochloride);SRI-011381 hydrochloride, 10 mM in DMSO;SRI 011381 hydrochloride,multiple,Transforming growth factor beta,sclerosis,TGF-beta/Smad,α-SMA,NALP3,SRI 011381,collagen-1,SRI-011381,inhibit,TGF-β,neuroprotective,SRI011381,Inhibitor,SRI011381 hydrochloride
CBNumber: CB73146623
Molecular Formula: C20H32ClN3O
Formula Weight: 365.95
MOL File: 2070014-88-7.mol

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SRI-011381 (hydrochloride) Property

storage temp.: Store at -20°C
solubility: DMSO : 33.33 mg/mL (91.08 mM)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-5826
Product name: SRI-011381hydrochloride
Purity: 99.78%
Packaging: 5mg
Price: $144
Updated: 2021/12/16

ChemScene

Product number: CS-5826
Product name: SRI-011381hydrochloride
Purity: 99.78%
Packaging: 10mg
Price: $252
Updated: 2021/12/16

ChemScene

Product number: CS-5826
Product name: SRI-011381hydrochloride
Purity: 99.78%
Packaging: 25mg
Price: $540
Updated: 2021/12/16

ChemScene

Product number: CS-5826
Product name: SRI-011381hydrochloride
Purity: 99.78%
Packaging: 50mg
Price: $912
Updated: 2021/12/16

ChemScene

Product number: CS-5826
Product name: SRI-011381hydrochloride
Purity: 99.78%
Packaging: 100mg
Price: $1560
Updated: 2021/12/16

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SRI-011381 (hydrochloride) Chemical Properties,Usage,Production

Uses

SRI-011381 hydrochloride is an orally active TGF-β signaling agonist, exhibits neuroprotective effects[1][2].

in vivo

SRI-011381 (30 mg/kg; i.p.; every 2 d; for 22 days) hydrochloride partially rescues the deficits in optic nerve and retina of YAPGFAP-CKO EAE mice^[2].

Animal Model:	YAPGFAP-CKO mice bearing experimental autoimmune encephalomyelitis (EAE)^[2]
Dosage:	30 mg/kg
Administration:	Intraperitoneally injection; every 2 d; for 22 days
Result:	Significantly inhibited inflammatory infiltration and relieved the loss of neurons in YAPGFAP-CKO EAE mice.

References

[1] Jingyin Han, et al. The Improvement Effect of Sodium Ferulate on the Formation of Pulmonary Fibrosis in Silicosis Mice Through the Neutrophil Alkaline Phosphatase 3 (NALP3)/Transforming Growth Factor-β1 (TGF-β1)/α-Smooth Muscle Actin (α-SMA) Pathway. Med Sci Monit. 2021 Jun 15;27:e927978. DOI:10.12659/MSM.927978
[2] Qian Wu, et al. Astrocytic YAP protects the optic nerve and retina in an experimental autoimmune encephalomyelitis model through TGF-β signaling. Theranostics. 2021 Jul 25;11(17):8480-8499. DOI:10.7150/thno.60031

SRI-011381 (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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SRI-011381 (hydrochloride) Suppliers

China 32 United States 2 Global 34

AdooQ Bioscience CHINA

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Anqing Rong Chuang Biological Technology Co., Ltd.

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2070014-88-7, SRI-011381 (hydrochloride)Related Search:

SRI-011381 SRI011381 N'-Cyclohexyl-N-(phenylmethyl)-N-(4-piperidinylmethyl)-urea

SRI-011381 (hydrochloride)

SRI 011381 hydrochloride,multiple,Transforming growth factor beta,sclerosis,TGF-beta/Smad,α-SMA,NALP3,SRI 011381,collagen-1,SRI-011381,inhibit,TGF-β,neuroprotective,SRI011381,Inhibitor,SRI011381 hydrochloride

SRI-011381 hydrochloride, 10 mM in DMSO

2070014-88-7