ChemicalBook > CAS DataBase List > SH5-07

SH5-07

Product Name
SH5-07
CAS No.
1456632-41-9
Chemical Name
SH5-07
Synonyms
SH5-07;SH5-07 (SH-5-07);SH5-07, 10 mM in DMSO;Inhibitor,SH5-07,SH5 07,inhibit,STAT,SH507,SH-5-07;4-(N-(4-Cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-methylphenylsulfonamido)acetamido)-N-hydroxybenzamide;Benzamide, 4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-N-hydroxy-
CBNumber
CB73147594
Molecular Formula
C29H28F5N3O5S
Formula Weight
625.61
MOL File
1456632-41-9.mol
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SH5-07 Property

Density 
1.437±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 50 mg/mL (79.92 mM);Water : < 0.1 mg/mL (insoluble)
form 
Solid
pka
9.03±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
S283000
Product name
SH5-​07
Packaging
2.5mg
Price
$580
Updated
2021/12/16
ChemScene
Product number
CS-6232
Product name
SH5-07
Purity
>98.0%
Packaging
1mg
Price
$84
Updated
2021/12/16
ChemScene
Product number
CS-6232
Product name
SH5-07
Purity
>98.0%
Packaging
5mg
Price
$252
Updated
2021/12/16
ChemScene
Product number
CS-6232
Product name
SH5-07
Purity
>98.0%
Packaging
10mg
Price
$420
Updated
2021/12/16
ChemScene
Product number
CS-6232
Product name
SH5-07
Purity
>98.0%
Packaging
50mg
Price
$1800
Updated
2021/12/16
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SH5-07 Chemical Properties,Usage,Production

Uses

SH5-?07 is a STAT3-inhibitor blocking the activation of signal transduction and subsequent activation of transcription 3 in chronic myeloid leukemia cell lines.

in vivo

Tail vein injection or oral gavage delivery of SH5-07 or SH4-54 inhibits growth of 90-150 mm3 established subcutaneous mouse xenografts of human glioma (U251MG) and breast (MDA-MB-231) tumors that harbor aberrantly-active Stat3, associated with decreased c-Myc, Mcl-1 and Cyclin D1 expression. No significant changes in body weights, blood cell counts, or the gross anatomy of organs, or obvious signs of toxicity are observed[1].

IC 50

STAT3: 3.9 μM (IC50)

SH5-07 Preparation Products And Raw materials

Raw materials

Preparation Products

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SH5-07 Suppliers

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1456632-41-9, SH5-07Related Search:

SH-4-54 SHA 68

  • SH5-07
  • SH5-07 (SH-5-07)
  • Benzamide, 4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-N-hydroxy-
  • Inhibitor,SH5-07,SH5 07,inhibit,STAT,SH507,SH-5-07
  • 4-(N-(4-Cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-methylphenylsulfonamido)acetamido)-N-hydroxybenzamide
  • SH5-07, 10 mM in DMSO
  • 1456632-41-9
  • C29H28F5N3O5S