ChemicalBook > CAS DataBase List > BAY-1082439

BAY-1082439

Product Name
BAY-1082439
CAS No.
1375469-38-7
Chemical Name
BAY-1082439
Synonyms
CS-2422;BAY 2439;BAY-1082439;BAY-1082439; BAY 2439;BAY10-82439; BAY 10-82439; BAY-10-82439; BAY1082439; BAY 1082439; BAY-1082439;(R)-N-(8-(2-hydroxy-3-morpholinopropoxy)-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)-2-methylnicotinamide;3-Pyridinecarboxamide, N-[2,3-dihydro-8-[(2R)-2-hydroxy-3-(4-morpholinyl)propoxy]-7-methoxyimidazo[1,2-c]quinazolin-5-yl]-2-methyl-;N-[8-[[(2R)-2-Hydroxy-3-(morpholin-4-yl)propyl]oxy]-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]-2-methylpyridine-3-carboxamide;BAY 1082439,BAY-1082439,PTEN,inhibit,cancer,oral,Inhibitor,forms,Phosphoinositide 3-kinase,PI3K,Apoptosis,BAY1082439,mutated,PIK3CA,prostate
CBNumber
CB73147620
Molecular Formula
C25H30N6O5
Formula Weight
494.54
MOL File
1375469-38-7.mol
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BAY-1082439 Property

Density 
1.43±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 5 mg/mL (10.11 mM; ultrasonic and adjust pH to 5 with HCl)
form 
A solid
pka
10.27±0.20(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0020548
Product name
BAY1082439
Purity
99.46%
Packaging
5mg
Price
$90
Updated
2021/12/16
ChemScene
Product number
CS-0020548
Product name
BAY1082439
Purity
99.46%
Packaging
10mg
Price
$150
Updated
2021/12/16
ChemScene
Product number
CS-0020548
Product name
BAY1082439
Purity
99.46%
Packaging
25mg
Price
$250
Updated
2021/12/16
ChemScene
Product number
CS-0020548
Product name
BAY1082439
Purity
99.46%
Packaging
50mg
Price
$450
Updated
2021/12/16
ChemScene
Product number
CS-0020548
Product name
BAY1082439
Purity
99.46%
Packaging
100mg
Price
$750
Updated
2021/12/16
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BAY-1082439 Chemical Properties,Usage,Production

Uses

BAY1082439 is an orally bioavailable, selective PI3Kα/β/δ inhibitor. BAY1082439 also inhibits mutated forms of PIK3CA. BAY1082439 is highly effective in inhibiting Pten-null prostate cancer growth[1][2].

in vivo

BAY1082439 (75 mg/kg; p.o.; daily for 4 weeks) is effective in preventing Pten-null prostate cancer progression[2].

Animal Model: Pten conditional knockout mouse model (Pb-Cre+;PtenL/L, CP model)[2]
Dosage:75 mg/kg
Administration:P.o.; daily for 4 weeks
Result:Significantly decreased tumor size and P-AKT staining, nearly normal luminal architecture, and a significant reduction of Ki67-positive cells. Significantly inhibit the human prostate cancer growth.

IC 50

PI3Kα; PI3Kβ; PI3Kδ

References

[1] Ningshu Liu, et al. Abstract 2799: BAY 1082439, a highly selective and balanced PI3Kα/β inhibitor demonstrated potent activity in tumors with activated PI3Kα and loss-of-function of PTEN. Abstract nr 2799. doi:1538-7445.AM2012-2799.
[2] Yongkang Zou, et al. Co-Targeting the Cell Intrinsic and Microenvironment Pathways of Prostate Cancer by PI3Kα/β/δ inhibitor BAY1082439. Mol Cancer Ther. 2018 Oct;17(10):2091-2099. DOI:10.1158/1535-7163.MCT-18-0038

BAY-1082439 Preparation Products And Raw materials

Raw materials

Preparation Products

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BAY-1082439 Suppliers

China 57 United States 5 Global 62
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
Chembest Research Laboratories Limited
Tel
021-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
Advantage
61
Shanghai YuanQi Biotechnology Co., Ltd.
Tel
+86-2332782371 +86-18120098618
Email
sales@adobechem.com
Country
China
ProdList
1250
Advantage
50
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4817
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
86249
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9505
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 18101056239
Email
3193328036@qq.com
Country
China
ProdList
29661
Advantage
68
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
Zhongshan Geometric Biological Technology Co., Ltd.
Tel
Email
2953972351@qq.com
Country
China
ProdList
253
Advantage
58
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View Lastest Price from BAY-1082439 manufacturers

Career Henan Chemical Co
Product
BAY-1082439 1375469-38-7
Price
US $1.00/KG
Min. Order
1KG
Purity
97%-99.9%
Supply Ability
100kg
Release date
2019-12-25

1375469-38-7, BAY-1082439Related Search:


  • BAY-1082439
  • BAY 2439
  • N-[8-[[(2R)-2-Hydroxy-3-(morpholin-4-yl)propyl]oxy]-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]-2-methylpyridine-3-carboxamide
  • BAY-1082439; BAY 2439
  • (R)-N-(8-(2-hydroxy-3-morpholinopropoxy)-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)-2-methylnicotinamide
  • BAY10-82439; BAY 10-82439; BAY-10-82439; BAY1082439; BAY 1082439; BAY-1082439
  • CS-2422
  • BAY 1082439,BAY-1082439,PTEN,inhibit,cancer,oral,Inhibitor,forms,Phosphoinositide 3-kinase,PI3K,Apoptosis,BAY1082439,mutated,PIK3CA,prostate
  • 3-Pyridinecarboxamide, N-[2,3-dihydro-8-[(2R)-2-hydroxy-3-(4-morpholinyl)propoxy]-7-methoxyimidazo[1,2-c]quinazolin-5-yl]-2-methyl-
  • 1375469-38-7