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2-Chloro-5-(difluoromethoxy)pyrimidine

Product Name
2-Chloro-5-(difluoromethoxy)pyrimidine
CAS No.
1192813-64-1
Chemical Name
2-Chloro-5-(difluoromethoxy)pyrimidine
Synonyms
2-Chloro-5-(difluoromethoxy)pyrimidine;Pyrimidine, 2-chloro-5-(difluoromethoxy)-;2-chloro-5-[(difluoromethyl)oxy]pyrimidine
CBNumber
CB73150785
Molecular Formula
C5H3ClF2N2O
Formula Weight
180.54
MOL File
1192813-64-1.mol
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2-Chloro-5-(difluoromethoxy)pyrimidine Property

Boiling point:
260.1±30.0 °C(Predicted)
Density 
1.466±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-2.63±0.22(Predicted)
form 
liquid
color 
Clear, colourless
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Apolloscientific
Product number
PC56706
Product name
2-Chloro-5-(difluoromethoxy)pyrimidine
Purity
95%
Packaging
250mg
Price
$114
Updated
2021/12/16
Apolloscientific
Product number
PC56706
Product name
2-Chloro-5-(difluoromethoxy)pyrimidine
Purity
95%
Packaging
500mg
Price
$192
Updated
2021/12/16
Ambeed
Product number
A812296
Product name
2-Chloro-5-(difluoromethoxy)pyrimidine
Purity
95%
Packaging
100mg
Price
$100
Updated
2021/12/16
Ambeed
Product number
A812296
Product name
2-Chloro-5-(difluoromethoxy)pyrimidine
Purity
95%
Packaging
250mg
Price
$172
Updated
2021/12/16
Crysdot
Product number
CD11334854
Product name
2-Chloro-5-(difluoromethoxy)pyrimidine
Purity
97%
Packaging
1g
Price
$236
Updated
2021/12/16
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2-Chloro-5-(difluoromethoxy)pyrimidine Chemical Properties,Usage,Production

Synthesis

1895-39-2

4983-28-2

1192813-64-1

Step A: Synthesis of 2-chloro-5-(difluoromethoxy)pyrimidine 2-Chloropyrimidin-5-ol (1 g, 7.66 mmol) and sodium 2-chloro-2,2-difluoroacetate (3.50 g, 22.98 mmol) were dissolved in N,N-dimethylformamide (20 mL), water (0.2 mL) was added, and the reaction mixture was heated to 90 °C for 24 hours. After completion of the reaction, the solvent was removed by vacuum concentration. The crude product was purified by column chromatography (eluent: 5-30% ethyl acetate/hexane) to afford 2-chloro-5-(difluoromethoxy)pyrimidine (549 mg, 3.04 mmol, 39.7% yield) as a light yellow oil. Mass spectrometry (LC/MS) analysis showed retention time (R.T.) = 1.32 min; [M+H]+ = 181.14.

References

[1] Patent: US2009/270405, 2009, A1. Location in patent: Page/Page column 90
[2] Patent: WO2011/53292, 2011, A1. Location in patent: Page/Page column 149-150

2-Chloro-5-(difluoromethoxy)pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-5-(difluoromethoxy)pyrimidine Suppliers

China 52 India 1 United States 4 Global 57
A.J Chemicals
Tel
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Fax
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Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
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1192813-64-1, 2-Chloro-5-(difluoromethoxy)pyrimidineRelated Search:


  • 2-Chloro-5-(difluoromethoxy)pyrimidine
  • Pyrimidine, 2-chloro-5-(difluoromethoxy)-
  • 2-chloro-5-[(difluoromethyl)oxy]pyrimidine
  • 1192813-64-1