ChemicalBook > CAS DataBase List > CHIR-99021 (monohydrochloride)

CHIR-99021 (monohydrochloride)

Product Name: CHIR-99021 (monohydrochloride)
CAS No.: 1797989-42-4
Chemical Name: CHIR-99021 (monohydrochloride)
Synonyms: CT99021) HCl;CHIR-99012 HCl;CHIR99021; CHIR 99021;Laduviglusib (CHIR-99021;CT-99021 monohydrochloride);SCQDMKUZHIGAIB-UHFFFAOYSA-O;CHIR-99022 monohydrochloride;Laduviglusib (CHIR-99021) HCl;CHIR-99021 HCl, 10 mM in DMSO;Laduviglusib monohydrochloride
CBNumber: CB73152077
Molecular Formula: C22H19Cl3N8
Formula Weight: 501.8
MOL File: 1797989-42-4.mol

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CHIR-99021 (monohydrochloride) Property

storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: ≥25.1 mg/mL in DMSO; ≥4.23 mg/mL in H2O; ≥4.83 mg/mL in EtOH
form: solid
color: White to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C292150
Product name: CHIR-99021Hydrochloride
Packaging: 100mg
Price: $1390
Updated: 2021/12/16

ChemScene

Product number: CS-5969
Product name: CHIR-99021(monohydrochloride)
Purity: 99.93%
Packaging: 5mg
Price: $80
Updated: 2021/12/16

ChemScene

Product number: CS-5969
Product name: CHIR-99021(monohydrochloride)
Purity: 99.93%
Packaging: 10mg
Price: $110
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BC162488
Product name: CHIR 99021 hydrochloride
Packaging: 10mg
Price: $125
Updated: 2021/12/16

ApexBio Technology

Product number: A8396
Product name: CHIR-99021(CT99021)HCl
Packaging: 25mg
Price: $210
Updated: 2021/12/16

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CHIR-99021 (monohydrochloride) Chemical Properties,Usage,Production

Uses

CHIR-99021 is a potent and highly selective inhibitor of glycogen synthase kinase 3 (GSK-3). CHIR-99021 activates glycogen synthesis in CHO-IR cells and in isolated type 1 diabetic rat skeletal muscle. CHIR-99021 has also been shown to induce the reprogramming of murine and human somatic cells into stem cells. GSK-3α/β inhibitor

Biological Activity

chir-99021 is a highly specific glycogen synthase kinase-3 (gsk-3) inhibitor which can inhibit both isoforms with ic50 of 10 nm (gsk-3α) and 6.7 nm (gsk-3β).chir-99021 was proved to promote self-renewal and maintain pluripotency of both b6 and balb/c es cells via stabilizing the downstream effectors like c-myc and β -catenin[1]. in j1 mesc cells, chir-99021 played an important role in maintaining the colony morphology as well as the self-renewal when combined with leukemia inhibitory factor (lif). chir-99021 has shown to regulate multiple signaling pathways which involve wnt/β-catenin, tgf-β, nodal and mapk, and the expression of epigenetic regulatory genes like dnmt3l[2].chir-99021 has been demonstrated to promote dn3 thymocytes proliferation and differentiation in the absence of pre-tcr signaling, notch1 signaling or cxcl12[3]. however, study has also found that higher concentration (10 μm but not 1 μm or 3 μm) of chir99021 might selectively inhibit differentiation by activating il-7 signaling pathway[3].

in vivo

In ZDF rats, a single oral dose of Laduviglusib (16 mg/kg or 48 mg/kg) monohydrochloride rapidly lowers plasma glucose, with a maximal reduction of nearly 150 mg/dl 3-4 h after administration^[1]. Laduviglusib (2 mg/kg) monohydrochloride given once, 4 h before irradiation, significantly improves survival after 14.5 Gy abdominal irradiation (ABI). Laduviglusib monohydrochloride treatment significantly blocks crypt apoptosis and accumulation of p-H2AX⁺ cells, and improves crypt regeneration and villus height. Laduviglusib monohydrochloride treatment increases Lgr5⁺ cell survival by blocking apoptosis, and effectively prevents the reduction of Olfm4, Lgr5 and CD44 as early as 4 h^[5].

IC 50

GSK-3β: 6.7 nM (IC₅₀); GSK-3α: 10 nM (IC₅₀); cdc2: 8800 nM (IC₅₀)

References

1. ye s1, tan l, yang r, fang b, qu s, schulze en, song h, ying q, li p. pleiotropy of glycogen synthase kinase-3 inhibition by chir99021 promotes self-renewal of embryonic stem cells from refractory mouse strains. plos one. 2012;7(4):e35892.2. wu y1, ai z, yao k, cao l, du j, shi x, guo z, zhang y. chir99021 promotes self-renewal of mouse embryonic stem cells by modulation of protein-encoding gene and long intergenic non-coding rna expression. exp cell res. 20133. plos one. 2013;8(3):e58501. doi: 10.1371/journal.pone.0058501. epub 2013 mar 20. schroeder jh1, bell ls, janas ml, turner m. pharmacological inhibition of glycogen synthase kinase 3 regulates t cell development in vitro. plos one. 2013;8(3):e58501.

CHIR-99021 (monohydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from CHIR-99021 (monohydrochloride) manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: CHIR-99021 (monohydrochloride) 1797989-42-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-03-31

1797989-42-4, CHIR-99021 (monohydrochloride)Related Search:

CHIR-99021 (monohydrochloride)

SCQDMKUZHIGAIB-UHFFFAOYSA-O

CHIR-99012 HCl

CHIR-99021 monohydrochloride (CT99021 monohydrochloride

CT-99021 monohydrochloride)

CHIR99021; CHIR 99021

6-((2-((4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile monohydrochloride

qG5vVwxfPF/dMaEPgZ7+M/k7MBlUGzQfmx2dQNzco3OxOjBLUhcoA8ExqgSJg+Mi9TJ2Ez1/UWqzXslgraXDCQ==

Laduviglusib (CHIR-99021) HCl

Laduviglusib monohydrochloride

CT99021) HCl

Laduviglusib (CHIR-99021

CHIR-99021 HCl, 10 mM in DMSO

CHIR-99022 monohydrochloride

CHIR-99021 (CT99021) hydrochloride

1797989-42-4