CHIR-99021 (monohydrochloride)
- Product Name
- CHIR-99021 (monohydrochloride)
- CAS No.
- 1797989-42-4
- Chemical Name
- CHIR-99021 (monohydrochloride)
- Synonyms
- CT99021) HCl;CHIR-99012 HCl;CHIR99021; CHIR 99021;Laduviglusib (CHIR-99021;CT-99021 monohydrochloride);SCQDMKUZHIGAIB-UHFFFAOYSA-O;Laduviglusib (CHIR-99021) HCl;Laduviglusib monohydrochloride;CHIR-99021 (monohydrochloride);CHIR-99021 monohydrochloride (CT99021 monohydrochloride
- CBNumber
- CB73152077
- Molecular Formula
- C22H19Cl3N8
- Formula Weight
- 501.8
- MOL File
- 1797989-42-4.mol
CHIR-99021 (monohydrochloride) Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- ≥25.1 mg/mL in DMSO; ≥4.23 mg/mL in H2O; ≥4.83 mg/mL in EtOH
- form
- solid
- color
- White to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C292150
- Product name
- CHIR-99021Hydrochloride
- Packaging
- 100mg
- Price
- $1390
- Updated
- 2021/12/16
- Product number
- CS-5969
- Product name
- CHIR-99021(monohydrochloride)
- Purity
- 99.93%
- Packaging
- 5mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- CS-5969
- Product name
- CHIR-99021(monohydrochloride)
- Purity
- 99.93%
- Packaging
- 10mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- BC162488
- Product name
- CHIR 99021 hydrochloride
- Packaging
- 10mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- A8396
- Product name
- CHIR-99021(CT99021)HCl
- Packaging
- 25mg
- Price
- $210
- Updated
- 2021/12/16
CHIR-99021 (monohydrochloride) Chemical Properties,Usage,Production
Uses
CHIR-99021 is a potent and highly selective inhibitor of glycogen synthase kinase 3 (GSK-3). CHIR-99021 activates glycogen synthesis in CHO-IR cells and in isolated type 1 diabetic rat skeletal muscle. CHIR-99021 has also been shown to induce the reprogramming of murine and human somatic cells into stem cells. GSK-3α/β inhibitor
Biological Activity
chir-99021 is a highly specific glycogen synthase kinase-3 (gsk-3) inhibitor which can inhibit both isoforms with ic50 of 10 nm (gsk-3α) and 6.7 nm (gsk-3β).chir-99021 was proved to promote self-renewal and maintain pluripotency of both b6 and balb/c es cells via stabilizing the downstream effectors like c-myc and β -catenin[1]. in j1 mesc cells, chir-99021 played an important role in maintaining the colony morphology as well as the self-renewal when combined with leukemia inhibitory factor (lif). chir-99021 has shown to regulate multiple signaling pathways which involve wnt/β-catenin, tgf-β, nodal and mapk, and the expression of epigenetic regulatory genes like dnmt3l[2].chir-99021 has been demonstrated to promote dn3 thymocytes proliferation and differentiation in the absence of pre-tcr signaling, notch1 signaling or cxcl12[3]. however, study has also found that higher concentration (10 μm but not 1 μm or 3 μm) of chir99021 might selectively inhibit differentiation by activating il-7 signaling pathway[3].
References
1. ye s1, tan l, yang r, fang b, qu s, schulze en, song h, ying q, li p. pleiotropy of glycogen synthase kinase-3 inhibition by chir99021 promotes self-renewal of embryonic stem cells from refractory mouse strains. plos one. 2012;7(4):e35892.2. wu y1, ai z, yao k, cao l, du j, shi x, guo z, zhang y. chir99021 promotes self-renewal of mouse embryonic stem cells by modulation of protein-encoding gene and long intergenic non-coding rna expression. exp cell res. 20133. plos one. 2013;8(3):e58501. doi: 10.1371/journal.pone.0058501. epub 2013 mar 20. schroeder jh1, bell ls, janas ml, turner m. pharmacological inhibition of glycogen synthase kinase 3 regulates t cell development in vitro. plos one. 2013;8(3):e58501.
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