AVex-73
- Product Name
- AVex-73
- CAS No.
- 195615-83-9
- Chemical Name
- AVex-73
- Synonyms
- AE37;AE38;AVex-73;CS-2603;Blarcamesine (AVex-73);ANAVEX-2-73(Blarcamesine);Blarcamesine (Anavex-2-73);Blarcamesine, 10 mM in DMSO;1-(2,2-diphenyloxolan-3-yl)-N,N-dimethylmethanamine;3-Furanmethanamine, tetrahydro-N,N-dimethyl-2,2-diphenyl-
- CBNumber
- CB73152183
- Molecular Formula
- C19H23NO
- Formula Weight
- 281.39
- MOL File
- 195615-83-9.mol
AVex-73 Property
- solubility
- DMF: 30 mg/ml
DMSO: Slightly soluble
Ethanol: 30 mg/ml - form
- Solid
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- DC10732
- Product name
- Anavex-2-73freebase(Blarcamesine)
- Purity
- >98%
- Packaging
- 250mg
- Price
- $900
- Updated
- 2021/12/16
AVex-73 Chemical Properties,Usage,Production
Uses
Blarcamesine is an orally bioavailable Sigma-1 receptor agonist and muscarinic receptor modulator, with anticonvulsant, anti-amnesic, neuroprotective and antidepressant properties. Blarcamesine ameliorates neurologic impairments in a mouse model of Rett syndrome[1].
in vivo
Blarcamesine (10 mg/kg, 30 mg/kg; p.o.; daily; for 6.5 weeks) ameliorates motor deficits in Mecp2 HET mice with chronic administration[1].
Blarcamesine ameliorates acoustic startle deficit in Mecp2 HET mice[1].
Blarcamesine reverses deficits in visual acuity in older Mecp2 HET mice using the optokinetic response[1].
Blarcamesine produces minimal effects on body weight gain in Mecp2 HET mice[1].
| Animal Model: | Female Mecp2tm1.1Bird/J HET (C57 background) mice[1] |
| Dosage: | 10 mg/kg, 30 mg/kg |
| Administration: | Oral administration, daily, for 6.5 weeks |
| Result: | Reverse the deficits observed in the HET animals. |
IC 50
Sigma 1 Receptor
References
[1] Walter E Kaufmann, et al. ANAVEX?2-73 (Blarcamesine), a Sigma-1 Receptor Agonist, Ameliorates Neurologic Impairments in a Mouse Model of Rett Syndrome. Pharmacol Biochem Behav . 2019 Dec;187:172796. DOI:10.1016/j.pbb.2019.172796
[2] VALENTINE LAHMY. Mitochondrial protection by the mixed muscarinic/σ1 ligand ANAVEX2-73, a tetrahydrofuran derivative, in Aβ25-35 peptide-injected mice, a nontransgenic Alzheimer’s disease model.[J]. Frontiers in Cellular Neuroscience, 2015: 463. DOI: 10.3389/fncel.2014.00463
[3] VALENTINE LAHMY. Blockade of Tau Hyperphosphorylation and Aβ1–42 Generation by the Aminotetrahydrofuran Derivative ANAVEX2-73, a Mixed Muscarinic and σ1 Receptor Agonist, in a Nontransgenic Mouse Model of Alzheimer’s Disease[J]. Neuropsychopharmacology, 2013, 38 9: 1706-1723. DOI: 10.1038/npp.2013.70
AVex-73 Preparation Products And Raw materials
Raw materials
Preparation Products
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