HJC0197

Product Name: HJC0197
CAS No.: 1383539-73-8
Chemical Name: HJC0197
Synonyms: HJC0197;HJC 0197 (HJC0197);HJC0197, 10 mM in DMSO;6-Cyclopentyl-2-((2,5-dimethylbenzyl)thio)-4-oxo-1,4-dihydropyrimidine-5-carbonitrile;5-Pyrimidinecarbonitrile, 4-cyclopentyl-2-[[(2,5-dimethylphenyl)methyl]thio]-1,6-dihydro-6-oxo-;HJC0197,cAMP-signaling,activation,GEF,cellular,Ras,inhibit,HJC-0197,HJC 0197,phosphorylation,processes,Inhibitor
CBNumber: CB73152628
Molecular Formula: C19H21N3OS
Formula Weight: 339.45
MOL File: 1383539-73-8.mol

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HJC0197 Property

solubility: DMF: 10 mg/ml; DMF:PBS(pH7.2) (1:2): 0.2 mg/ml; DMSO: 5 mg/ml
form: A crystalline solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19092
Product name: HJC0197
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 19092
Product name: HJC0197
Purity: ≥98%
Packaging: 5mg
Price: $169
Updated: 2024/03/01

Cayman Chemical

Product number: 19092
Product name: HJC0197
Purity: ≥98%
Packaging: 10mg
Price: $283
Updated: 2024/03/01

ApexBio Technology

Product number: C3387
Product name: HJC0197
Packaging: 10mg
Price: $321
Updated: 2021/12/16

ApexBio Technology

Product number: C3387
Product name: HJC0197
Packaging: 5mg
Price: $192
Updated: 2021/12/16

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HJC0197 Chemical Properties,Usage,Production

Description

Exchange protein activated by cAMP (Epac) proteins mediate cAMP signaling independent of protein kinase A (PKA). HJC0197 is a cell-permeable inhibitor of Epac1 and Epac2 (IC₅₀ = 5.9 μM for Epac2). It inhibits Epac1-mediated Rap1-GDP exchange activity at 25 μM, but has no effect on cAMP-induced type I and II PKA activity at this concentration. Pretreatment of HEK293 cells expressing either Epac1 or Epac2 with 10 μM HJC0197 completely blocks Epac-mediated phosphorylation of Akt. HJC0197 has been used to study the role of Epac signaling in chondrogenesis in chicken micromass cultures.

Uses

HJC0197 is a potent Epac1 (exchange protein directly activated by cAMP 1) and Epac2 (IC50=5.9 μM for Epac2) antagonist. HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 inhibits Epac1-mediated Rap1-GDP exchange activity at 25 μM in the presence of equal concentration of cAMP[1].

References

[1] Chen H, et al. 5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP. Bioorg Med Chem Lett. 2012 Jun 15;22(12):4038-43. DOI:10.1016/j.bmcl.2012.04.082

HJC0197 Preparation Products And Raw materials

Raw materials

Preparation Products

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HJC0197 Suppliers

CHINA 37 United States 5 Global 42

Shanghai Lollane Biological Technology Co.,Ltd.

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1383539-73-8, HJC0197Related Search:

HJC 0197 (HJC0197)

HJC0197

5-Pyrimidinecarbonitrile, 4-cyclopentyl-2-[[(2,5-dimethylphenyl)methyl]thio]-1,6-dihydro-6-oxo-

HJC0197,cAMP-signaling,activation,GEF,cellular,Ras,inhibit,HJC-0197,HJC 0197,phosphorylation,processes,Inhibitor

6-Cyclopentyl-2-((2,5-dimethylbenzyl)thio)-4-oxo-1,4-dihydropyrimidine-5-carbonitrile

HJC0197, 10 mM in DMSO

1383539-73-8