HJC0197
- Product Name
- HJC0197
- CAS No.
- 1383539-73-8
- Chemical Name
- HJC0197
- Synonyms
- HJC0197;HJC 0197 (HJC0197);6-Cyclopentyl-2-((2,5-dimethylbenzyl)thio)-4-oxo-1,4-dihydropyrimidine-5-carbonitrile;5-Pyrimidinecarbonitrile, 4-cyclopentyl-2-[[(2,5-dimethylphenyl)methyl]thio]-1,6-dihydro-6-oxo-;HJC0197,cAMP-signaling,activation,GEF,cellular,Ras,inhibit,HJC-0197,HJC 0197,phosphorylation,processes,Inhibitor
- CBNumber
- CB73152628
- Molecular Formula
- C19H21N3OS
- Formula Weight
- 339.45
- MOL File
- 1383539-73-8.mol
HJC0197 Property
- solubility
- DMF: 10 mg/ml; DMF:PBS(pH7.2) (1:2): 0.2 mg/ml; DMSO: 5 mg/ml
- form
- A crystalline solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 19092
- Product name
- HJC0197
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 19092
- Product name
- HJC0197
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $169
- Updated
- 2024/03/01
- Product number
- 19092
- Product name
- HJC0197
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $283
- Updated
- 2024/03/01
- Product number
- C3387
- Product name
- HJC0197
- Packaging
- 10mg
- Price
- $321
- Updated
- 2021/12/16
- Product number
- C3387
- Product name
- HJC0197
- Packaging
- 5mg
- Price
- $192
- Updated
- 2021/12/16
HJC0197 Chemical Properties,Usage,Production
Description
Exchange protein activated by cAMP (Epac) proteins mediate cAMP signaling independent of protein kinase A (PKA). HJC0197 is a cell-permeable inhibitor of Epac1 and Epac2 (IC50 = 5.9 μM for Epac2). It inhibits Epac1-mediated Rap1-GDP exchange activity at 25 μM, but has no effect on cAMP-induced type I and II PKA activity at this concentration. Pretreatment of HEK293 cells expressing either Epac1 or Epac2 with 10 μM HJC0197 completely blocks Epac-mediated phosphorylation of Akt. HJC0197 has been used to study the role of Epac signaling in chondrogenesis in chicken micromass cultures.
HJC0197 Preparation Products And Raw materials
Raw materials
Preparation Products
HJC0197 Suppliers
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