ChemicalBook > CAS DataBase List > HJC0197

HJC0197

Product Name
HJC0197
CAS No.
1383539-73-8
Chemical Name
HJC0197
Synonyms
HJC0197;HJC 0197 (HJC0197);6-Cyclopentyl-2-((2,5-dimethylbenzyl)thio)-4-oxo-1,4-dihydropyrimidine-5-carbonitrile;5-Pyrimidinecarbonitrile, 4-cyclopentyl-2-[[(2,5-dimethylphenyl)methyl]thio]-1,6-dihydro-6-oxo-;HJC0197,cAMP-signaling,activation,GEF,cellular,Ras,inhibit,HJC-0197,HJC 0197,phosphorylation,processes,Inhibitor
CBNumber
CB73152628
Molecular Formula
C19H21N3OS
Formula Weight
339.45
MOL File
1383539-73-8.mol
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HJC0197 Property

solubility 
DMF: 10 mg/ml; DMF:PBS(pH7.2) (1:2): 0.2 mg/ml; DMSO: 5 mg/ml
form 
A crystalline solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19092
Product name
HJC0197
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
19092
Product name
HJC0197
Purity
≥98%
Packaging
5mg
Price
$169
Updated
2024/03/01
Cayman Chemical
Product number
19092
Product name
HJC0197
Purity
≥98%
Packaging
10mg
Price
$283
Updated
2024/03/01
ApexBio Technology
Product number
C3387
Product name
HJC0197
Packaging
10mg
Price
$321
Updated
2021/12/16
ApexBio Technology
Product number
C3387
Product name
HJC0197
Packaging
5mg
Price
$192
Updated
2021/12/16
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HJC0197 Chemical Properties,Usage,Production

Description

Exchange protein activated by cAMP (Epac) proteins mediate cAMP signaling independent of protein kinase A (PKA). HJC0197 is a cell-permeable inhibitor of Epac1 and Epac2 (IC50 = 5.9 μM for Epac2). It inhibits Epac1-mediated Rap1-GDP exchange activity at 25 μM, but has no effect on cAMP-induced type I and II PKA activity at this concentration. Pretreatment of HEK293 cells expressing either Epac1 or Epac2 with 10 μM HJC0197 completely blocks Epac-mediated phosphorylation of Akt. HJC0197 has been used to study the role of Epac signaling in chondrogenesis in chicken micromass cultures.

HJC0197 Preparation Products And Raw materials

Raw materials

Preparation Products

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HJC0197 Suppliers

China 25 United States 5 Global 30
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
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China
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Shanghai Beckham Medical Technology Co., Ltd
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021-13816613772 13816613772
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QQ: 12922499
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huahero21@sina.com
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China
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450
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55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
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China
ProdList
9806
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58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
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China
ProdList
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ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
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QQ:2853530913
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2853530910@QQ.com
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China
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Shanghai SuperLan Chemcial Technique Centre
Tel
021-2022843681 15618226720
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+86-21-51601218
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lucy@atkchemical.com
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China
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Henan Alfa Chemical Co., Ltd
Tel
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China
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DC Chemicals
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021-58447131 13564518121
Email
sales@dcchemicals.com
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China
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MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
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58
Jinan Jiuli Biotechnology Co. , Ltd.
Tel
15865264761
Email
486064515@qq.com
Country
China
ProdList
3733
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58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
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China
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InvivoChem
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13549236410
Email
sales@invivochem.cn
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China
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TargetMol Chemicals Inc.
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4008200310
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marketing@tsbiochem.com
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China
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Nanjing Tengyi Biotechnology Co., Ltd
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025-58851786 17714337195
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sales@tybiochem.com
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Shanghai Jieshikai Biotechnology Co. , Ltd.
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021-57520305 15221441005
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lihua@jskchem.com
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Shanghai Aladdin Biochemical Technology Co.,Ltd.
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+86-18521732826
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market@aladdin-e.com
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ATK CHEMICAL COMPANY LIMITED
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+undefined-21-51877795
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+86 21 5161 9052/ 5187 7796
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ivan@atkchemical.com
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LEAPCHEM CO., LTD.
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+86-852-30606658
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market18@leapchem.com
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China
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Shanghai Hao Zhun Biological Technology Co., Ltd.
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info@zzsrm.com
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CHINA
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6650
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Beijing Luyuan Bird Biotechnology Co., Ltd.
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15810802415@139.com
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Beijing Fubo Biotechnology Co., Ltd.
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Shanghai Hao Biological Technology Co., Ltd.
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Morning Student Science and Technology (Guangzhou) Co., Ltd.
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Shanghai Weiwei Biological Technology Co., Ltd.
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Absin Bioscience Inc.
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1383539-73-8, HJC0197Related Search:


  • HJC 0197 (HJC0197)
  • HJC0197
  • 5-Pyrimidinecarbonitrile, 4-cyclopentyl-2-[[(2,5-dimethylphenyl)methyl]thio]-1,6-dihydro-6-oxo-
  • HJC0197,cAMP-signaling,activation,GEF,cellular,Ras,inhibit,HJC-0197,HJC 0197,phosphorylation,processes,Inhibitor
  • 6-Cyclopentyl-2-((2,5-dimethylbenzyl)thio)-4-oxo-1,4-dihydropyrimidine-5-carbonitrile
  • 1383539-73-8