ChemicalBook > CAS DataBase List > Leucettine L41

Leucettine L41

Product Name
Leucettine L41
CAS No.
1112978-84-3
Chemical Name
Leucettine L41
Synonyms
Leucettine L41;Leucettine L41,Leucettine L-41;4H-Imidazol-4-one, 5-(1,3-benzodioxol-5-ylmethylene)-3,5-dihydro-2-(phenylamino)-, (5Z)-
CBNumber
CB73152956
Molecular Formula
C17H13N3O3
Formula Weight
307.3
MOL File
1112978-84-3.mol
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Leucettine L41 Property

storage temp. 
Store at -20°C
solubility 
DMSO: soluble; Ethanol: soluble
form 
A solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29225
Product name
Leucettine L41
Packaging
1mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
29225
Product name
Leucettine L41
Packaging
10mg
Price
$448
Updated
2024/03/01
Cayman Chemical
Product number
29225
Product name
Leucettine L41
Packaging
5mg
Price
$239
Updated
2024/03/01
Usbiological
Product number
207259
Product name
Leucettine L41
Packaging
1mg
Price
$295
Updated
2021/12/16
Adipogen Life Sciences
Product number
AG-MR-C0023-M025
Product name
LeucettineL41
Purity
≥98%(NMR)
Packaging
25mg
Price
$880
Updated
2021/12/16
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Leucettine L41 Chemical Properties,Usage,Production

Description

Leucettine L41 is an inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A), DYRK2, CDC-like kinase 1 (CLK1), and CLK3 (IC50s = 0.04, 0.035, 0.015, and 4.5 μM, respectively).1 It also inhibits GSK3α/β and Pim1 with IC50 values of 0.41 and 4.1 μM, respectively. It inhibits phosphorylation of the serine/arginine (SR) protein 9G8 by DYRK2, DYRK3, CLK1, CLK2, and CLK4 and inhibits TNF-α-induced SRp75 and SRp55 phosphorylation in human microvascular endothelial cells when used at concentrations ranging from 0.1 to 10 μM. Leucettine L41 modulates alternative pre-RNA splicing of a synthetic CLK1 minigene in a reporter model. It prevents lipid peroxidation and the accumulation of reactive oxygen species (ROS) induced by amyloid-β 25-35 in the hippocampus in a mouse model of Alzheimer’s disease-like toxicity.2 Leucettine L41 (0.4, 1.2, and 4 μg, i.c.v.) also prevents memory deficits induced by amyloid-β 25-35 in the same model.

References

1. Debdab, M., Carreaux, F., Renault, S., et al. Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: Modulation of alternative pre-RNA splicing J. Med. Chem. 54(12),4172-4186(2011).
2. Naert, G., Ferré, V., Meunier, J., et al. Leucettine L41, a DYRK1A-preferential DYRKs/CLKs inhibitor, prevents memory impairments and neurotoxicity induced by oligomeric Aβ25-35 peptide administration in mice Eur. Neuropsychopharmacol. 25(11),2170-2182(2015).

Leucettine L41 Preparation Products And Raw materials

Raw materials

Preparation Products

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Leucettine L41 Suppliers

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1112978-84-3, Leucettine L41Related Search:


  • Leucettine L41
  • 4H-Imidazol-4-one, 5-(1,3-benzodioxol-5-ylmethylene)-3,5-dihydro-2-(phenylamino)-, (5Z)-
  • Leucettine L41,Leucettine L-41
  • 1112978-84-3
  • 112978-84-3