TB5

Product Name: TB5
CAS No.: 948841-07-4
Chemical Name: TB5
Synonyms: TB5;TB-5;TB 5;TB5, 10 mM in DMSO;MAO,TB-5,Monoamine Oxidase,TB 5,TB5,Inhibitor,inhibit;1-(5-Bromo-2-thienyl)-3-[4-(dimethylamino)phenyl]-2-propene-1-one;2-Propen-1-one, 1-(5-bromo-2-thienyl)-3-[4-(dimethylamino)phenyl]-, (2E)-
CBNumber: CB73156590
Molecular Formula: C15H14BrNOS
Formula Weight: 336.25
MOL File: 948841-07-4.mol

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TB5 Property

Boiling point:: 468.5±45.0 °C(Predicted)
Density: 1.440±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 33 mg/ml; DMSO: 33 mg/ml; Ethanol: 1 mg/ml
form: A crystalline solid
pka: 4.30±0.24(Predicted)
color: White to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2144
Product name: TB5
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $83.7
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2144
Product name: TB5
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $338
Updated: 2024/03/01

Cayman Chemical

Product number: 22947
Product name: TB5
Purity: ≥98%
Packaging: 1mg
Price: $26
Updated: 2024/03/01

Cayman Chemical

Product number: 22947
Product name: TB5
Purity: ≥98%
Packaging: 5mg
Price: $83
Updated: 2024/03/01

Cayman Chemical

Product number: 22947
Product name: TB5
Purity: ≥98%
Packaging: 10mg
Price: $153
Updated: 2024/03/01

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TB5 Chemical Properties,Usage,Production

Uses

(2E)-1-(5-Bromo-2-thienyl)-3-[4-(dimethylamino)phenyl]-2-propen-1-one is a monoamine oxidase B (MAO-B) inhibitor. Monoamine oxidase B is involved in the metabolism of dopamine. Mao-B inhibitors are potential compounds used to treat Parkinson's disease.

Biological Activity

TB5 is a potent and selective reversible inhibitor of monoamine oxidase B (MAOB) with a Ki value of 110 nM. A reversible inhibitor should have an advantage over irreversible inhibitors such as selegiline in limiting side effects. Parallel artificial membrane permeation (PAMPA) assays indicated TB5 should be able to cross the blood–brain barrier. TB5 was found nontoxic to cells.

TB5 Preparation Products And Raw materials

Raw materials

Preparation Products

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TB5 Suppliers

China 57 India 1 United States 8 Global 66

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948841-07-4, TB5Related Search:

1-(5-Bromo-2-thienyl)-3-[4-(dimethylamino)phenyl]-2-propene-1-one

TB-5;TB 5

TB5

MAO,TB-5,Monoamine Oxidase,TB 5,TB5,Inhibitor,inhibit

2-Propen-1-one, 1-(5-bromo-2-thienyl)-3-[4-(dimethylamino)phenyl]-, (2E)-

TB5, 10 mM in DMSO

948841-07-4