6-Maleimidocaproic acid-PFP ester

Product Name: 6-Maleimidocaproic acid-PFP ester
CAS No.: 692739-25-6
Chemical Name: 6-Maleimidocaproic acid-PFP ester
Synonyms: 6-Maleimidocaproic acid-PFP ester;6-maleimidohexanoic acid pentafluorophenyl ester;Perfluorophenyl 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoate;1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo-, pentafluorophenylester;1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo-, 2,3,4,5,6-pentafluorophenyl ester
CBNumber: CB73162818
Molecular Formula: C16H12F5NO4
Formula Weight: 377.26
MOL File: 692739-25-6.mol

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6-Maleimidocaproic acid-PFP ester Property

storage temp.: Storage temp. 2-8°C
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M137953
Product name: 6-Maleimidocaproicacidpentafluorophenylester
Packaging: 100mg
Price: $530
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: LIN0000110
Product name: 6-MALEIMIDOCAPROIC ACID PFP ESTER
Purity: 95.00%
Packaging: 5MG
Price: $508
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: LIN0000110
Product name: 6-MALEIMIDOCAPROIC ACID PFP ESTER
Purity: 95.00%
Packaging: 250MG
Price: $776
Updated: 2021/12/16

BroadPharm

Product number: BP-20416
Product name: 6-MaleimidocaproicacidPFPester
Purity: 96%
Packaging: 5G
Price: $1700
Updated: 2021/12/16

Chemenu

Product number: CM319431
Product name: Perfluorophenyl6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoate
Purity: 95%
Packaging: 250mg
Price: $426
Updated: 2021/12/16

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6-Maleimidocaproic acid-PFP ester Chemical Properties,Usage,Production

Description

6-Maleimidocaproic acid PFP ester contains a maleimide and PFP ester end group. Maleimides react with thiol groups within the pH range of 6.5 to 7.5 and form stable thioester bonds. PFP is an activated ester which can react with amine groups to form stable amide bonds.

Uses

6-Maleimidocaproic acid-PFP ester is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

Alkyl-Chain

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

6-Maleimidocaproic acid-PFP ester Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Maleimidocaproic acid-PFP ester Suppliers

China 27 India 1 United States 5 Global 33

Shanghai Raise Chemical Technology Co.,Ltd

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692739-25-6, 6-Maleimidocaproic acid-PFP esterRelated Search:

6-Maleimidocaproic acid

Perfluorophenyl 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoate

6-Maleimidocaproic acid-PFP ester

1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo-, pentafluorophenylester

1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo-, 2,3,4,5,6-pentafluorophenyl ester

6-maleimidohexanoic acid pentafluorophenyl ester

692739-25-6

C16H12F5NO4