Azido-PEG8-PFP ester
- Product Name
- Azido-PEG8-PFP ester
- CAS No.
- 2055014-62-3
- Chemical Name
- Azido-PEG8-PFP ester
- Synonyms
- Azido-PEG8-PFP ester;N3-PEG8-CH2CH2COOPFP;perfluorophenyl 1-azido-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oate;(2,3,4,5,6-pentafluorophenyl) 3-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
- CBNumber
- CB73162883
- Molecular Formula
- C25H36F5N3O10
- Formula Weight
- 633.57
- MOL File
- 2055014-62-3.mol
Azido-PEG8-PFP ester Property
- solubility
- Soluble in DMSO, DCM, DMF
- form
- Liquid
- color
- Colorless to light yellow
Safety
- HS Code
- 2942000090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- BP-21865
- Product name
- Azido-PEG8-PFPester
- Purity
- 98%
- Packaging
- 100mg
- Price
- $280
- Updated
- 2021/12/16
- Product number
- BP-21865
- Product name
- Azido-PEG8-PFPester
- Purity
- 98%
- Packaging
- 250mg
- Price
- $480
- Updated
- 2021/12/16
- Product number
- BIPG1167
- Product name
- Azido-PEG8-PFP ester
- Packaging
- 100mg
- Price
- $546
- Updated
- 2021/12/16
- Product number
- BP-21865
- Product name
- Azido-PEG8-PFPester
- Purity
- 98%
- Packaging
- 1g
- Price
- $980
- Updated
- 2021/12/16
Azido-PEG8-PFP ester Chemical Properties,Usage,Production
Description
Azido-PEG8-PFP ester is a monodisperse PEG linker consisting of an azide and PFP ester moities. The azide can participate in Click Chemistry reactions with alkynes, DBCO and BCN to form triazole groups. The PFP ester is amine-reactive and is less susceptible toward hydrolysis compared to NHS ester.
Uses
Azido-PEG8-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG8-PFP ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Azido-PEG8-PFP ester Preparation Products And Raw materials
Raw materials
Preparation Products
Azido-PEG8-PFP ester Suppliers
- Tel
- --
- Fax
- --
- sales@apolloscientific.co.uk
- Country
- United Kingdom
- ProdList
- 6084
- Advantage
- 88