RA190

Product Name: RA190
CAS No.: 1617495-03-0
Chemical Name: RA190
Synonyms: RA190;RA-190; RA 190;RA190 hydrochloride;RA190, 10 mM in DMSO;RPN13 Inhibitor, RA190;RA 190,inhibit,Proteasome,RA-190,Inhibitor,RA190;1-(L-phenylalanyl)-3,5-bis(3,4-dichlorobenzylidene)piperidin-4-one hydrochloride
CBNumber: CB73165778
Molecular Formula: C28H23Cl5N2O2
Formula Weight: 596.75
MOL File: 1617495-03-0.mol

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RA190 Property

storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO : ≥ 100 mg/mL (167.57 mM);Water : < 0.1 mg/mL (insoluble)
form: Solid
color: Light yellow to yellow
Water Solubility: water: 5mg/mL
DMSO: 50mg/mL

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6404
Product name: RA190
Purity: 99.47%
Packaging: 5mg
Price: $156
Updated: 2021/12/16

ChemScene

Product number: CS-6404
Product name: RA190
Purity: 99.47%
Packaging: 10mg
Price: $228
Updated: 2021/12/16

ChemScene

Product number: CS-6404
Product name: RA190
Purity: 99.47%
Packaging: 25mg
Price: $348
Updated: 2021/12/16

ChemScene

Product number: CS-6404
Product name: RA190
Purity: 99.47%
Packaging: 50mg
Price: $624
Updated: 2021/12/16

ChemScene

Product number: CS-6404
Product name: RA190
Purity: 99.47%
Packaging: 100mg
Price: $1104
Updated: 2021/12/16

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RA190 Chemical Properties,Usage,Production

Uses

RA190, a bis-benzylidine piperidon, inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13.

Biological Activity

Cell permeable: yes', 'Primary Target
RPN13/ADRM1', 'Reversible: no

in vivo

RA190 distributes to plasma and major organs excepting brain, and inhibits proteasome function in skin and muscle. RA190 administration profoundly reduces growth of multiple myeloma and ovarian cancer xenografts, and oral RA190 treatment retards HPV16⁺ syngeneic mouse tumor growth, without impacting spontaneous HPV-specific CD8⁺ T cell responses^[1].

References

[1] Anchoori RK, et al. A bis-benzylidine piperidone targeting proteasome ubiquitin receptor RPN13/ADRM1 as a therapy for cancer. Cancer Cell. 2013 Dec 9;24(6):791-805. DOI:10.1016/j.ccr.2013.11.001

RA190 Preparation Products And Raw materials

Raw materials

Preparation Products

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RA190 Suppliers

China 42 United States 4 Global 46

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7778
Advantage: 56

Chengdu Chuangkecheng Biological Technology Co., Ltd.

Tel: 028-028-0000000 13008177686
Fax: 15928581901
Email: sales@ckcbiotech.com
Country: China
ProdList: 904
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9125
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

HANGZHOU CLAP TECHNOLOGY CO.,LTD

Tel: 86-571-88216897,88216896 13588875226
Fax: 86-571-88216895
Email: sales@hzclap.com
Country: CHINA
ProdList: 6312
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
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Shanghai Zeye Biotechnology Co., Ltd.

Tel: 021-021-61998551 13122364865
Email: sale1@shzysw.net
Country: China
ProdList: 9778
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Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
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1617495-03-0, RA190Related Search:

Barium carbonate 3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide

RA-190; RA 190

RA190

RA190 hydrochloride

RA 190,inhibit,Proteasome,RA-190,Inhibitor,RA190

1-(L-phenylalanyl)-3,5-bis(3,4-dichlorobenzylidene)piperidin-4-one hydrochloride

RA190, 10 mM in DMSO

RPN13 Inhibitor, RA190

1617495-03-0