COTI-2
- Product Name
- COTI-2
- CAS No.
- 1039455-84-9
- Chemical Name
- COTI-2
- Synonyms
- COTI-2;COTI-2;COTI 2;COTI2;N'-(6,7-Dihydroquinolin-8(5H)-ylidene)-4-(pyridin-2-yl)piperazine-1-carbothiohydrazide;N'-(6,7-Dihydroquinolin-8(5H)-ylidene)-4-(pyridin-2-yl)piperazine-1-carbothiohydrazide;1-Piperazinecarbothioic acid, 4-(2-pyridinyl)-, 2-(6,7-dihydro-8(5H)-quinolinylidene)hydrazide;inhibit,Inhibitor,HNSCC,low,anti-cancer,anti-proliferative,toxicity,TNBC,COTI-2,MDM-2/p53,Apoptosis,orally
- CBNumber
- CB73165804
- Molecular Formula
- C19H22N6S
- Formula Weight
- 366.48
- MOL File
- 1039455-84-9.mol
COTI-2 Property
- storage temp.
- 2-8°C
- solubility
- ≤1mg/ml in DMSO;2.5mg/ml in dimethyl formamide
- form
- crystalline solid
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- 20031
- Product name
- COTI-2
- Purity
- ≥95% (E/Z mixture)
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 20031
- Product name
- COTI-2
- Purity
- ≥95% (E/Z mixture)
- Packaging
- 5mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 20031
- Product name
- COTI-2
- Purity
- ≥95% (E/Z mixture)
- Packaging
- 10mg
- Price
- $214
- Updated
- 2024/03/01
- Product number
- 20031
- Product name
- COTI-2
- Purity
- ≥95% (E/Z mixture)
- Packaging
- 25mg
- Price
- $456
- Updated
- 2024/03/01
- Product number
- C725025
- Product name
- COTI2
- Packaging
- 25mg
- Price
- $580
- Updated
- 2021/12/16
COTI-2 Chemical Properties,Usage,Production
Uses
COTI 2, efficiently inhibits the proliferation rate of all the tested cell lines following 72 h of treatment. COTI-2 is significantly effective at inhibiting tumor cell proliferation in all three cell lines (COLO-205, HCT-15, and SW620).
Biological Activity
coti-2 activates mutant forms of p53.p53 has varoius mechanisms of anticancer function and plays a critical role in genomic stability, apoptosis and inhibition of angiogenesis.
in vitro
previous study tested the efficacy of coti-2 against a diverse group of human cancer cell lines with different genetic mutation backgrounds. results showed that coti-2 efficiently inhibited the proliferation rate of all the tested cell lines following 72 h of treatment. most cell lines showed nanomolar sensitivity to coti-2 treatment. in addition, coti-2 was significantly more effective at inhibiting tumor cell proliferation than either cetuximab or erlotinib in colo-205, hct-15, and sw620 cell lines. notably, all three lines were insensitive to growth inhibition to any degree in response to low concentrations of cetuximab and erlotinib, but highly sensitive to even low doses of coti-2 [1].
in vivo
the effects of coti-2 on inhibiting the growth of ht-29 and shp-77 xenografts in immunocompromised mice was assessed when intraperitoneally administered. it was found that coti-2 at 10 mg/kg could significantly inhibit tumor growth in the ht-29 human colorectal tumor xenografts. in addition to reducing tumor volumes at specific times post-treatment, coti-2 could also delay the time required for tumors to reach specified volumes [1].
References
[1] salim, k. y.,vareki, s.m.,danter, w.r., et al. coti-2, a novel small molecule that is active against multiple human cancer cell lines in vitro and in vivo. oncotarget 7(27), (2016).
[2] https://clinicaltrials. gov/ct2/show/nct02433626term=coti-2&rank=1
COTI-2 Preparation Products And Raw materials
Raw materials
Preparation Products
COTI-2 Suppliers
- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4512
- Advantage
- 55
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9806
- Advantage
- 58
- Tel
- 177-54423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 8011
- Advantage
- 62
- Tel
- 21-31433387 15618786686
- Fax
- QQ:1369748377
- sales@rechemscience.com
- Country
- China
- ProdList
- 2992
- Advantage
- 58
- Tel
- 021-2022843681 15618226720
- Fax
- +86-21-51601218
- lucy@atkchemical.com
- Country
- China
- ProdList
- 9204
- Advantage
- 58
- Tel
- 010-50973130 4009686088
- 3193328036@qq.com
- Country
- China
- ProdList
- 29785
- Advantage
- 68
- Tel
- 0519-83246372 13585352506
- Fax
- 0519-83246372
- Country
- China
- ProdList
- 1844
- Advantage
- 58
- Tel
- +86 18721201413
- Fax
- +86 (21) 5775-8967
- sales@biopharmaleader.com
- Country
- China
- ProdList
- 1720
- Advantage
- 58
- Tel
- 021-58111628 15800915896
- Fax
- QQ 3285589261
- sales@twochem.com
- Country
- China
- ProdList
- 1788
- Advantage
- 58
- Tel
- 021-54338626 18017892860
- Fax
- 021-54338626
- sales@tubepharm.com
- Country
- China
- ProdList
- 2416
- Advantage
- 58
- Tel
- 17317130613
- Fax
- QQ3358272972
- 3358272972@qq.com
- Country
- China
- ProdList
- 3251
- Advantage
- 58
- Tel
- 020-31155029 18902330969
- Fax
- 020-31155029
- sales@tomums.cn
- Country
- China
- ProdList
- 4696
- Advantage
- 58
- Tel
- 0571-85361029
- Fax
- 0571-85361029
- synstar518@163.com
- Country
- China
- ProdList
- 1990
- Advantage
- 58
- Tel
- 18081075745
- chemflowtech@sina.com
- Country
- China
- ProdList
- 1886
- Advantage
- 58
- Tel
- 86-571-88216897,88216896 13588875226
- Fax
- 86-571-88216895
- sales@hzclap.com
- Country
- CHINA
- ProdList
- 6312
- Advantage
- 58
- Tel
- +86-0371-86658258 +8613203830695
- Fax
- 0371-86658258
- laboratory@coreychem.com
- Country
- China
- ProdList
- 30240
- Advantage
- 58
- Tel
- 15021845385
- 765325601@qq.com
- Country
- China
- ProdList
- 3609
- Advantage
- 58
- Tel
- 021-58447131 13564518121
- sales@dcchemicals.com
- Country
- China
- ProdList
- 9409
- Advantage
- 58
- Tel
- 0519-85788828 13775037613
- sales@chemrenpharm.com
- Country
- China
- ProdList
- 3600
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11217
- Advantage
- 58
- Tel
- 88888888888
- hongquchem@qq.com
- Country
- China
- ProdList
- 5132
- Advantage
- 58
- Tel
- 021-51111890 15317326293
- sales@molnova.com
- Country
- China
- ProdList
- 4195
- Advantage
- 58
- Tel
- 15342225168
- yutianchun2007@126.com
- Country
- China
- ProdList
- 10002
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing1@energy-chemical.com
- Country
- China
- ProdList
- 44808
- Advantage
- 58
- Tel
- 021-69568360 18916172912
- order@med-bio.cn
- Country
- China
- ProdList
- 8140
- Advantage
- 58
- Tel
- 13348960310 13348960310
- 3003867561@qq.com
- Country
- China
- ProdList
- 10002
- Advantage
- 58
- Tel
- 15865264761
- 486064515@qq.com
- Country
- China
- ProdList
- 3650
- Advantage
- 58
- Tel
- 18964309092 18964309092
- 2769493375@qq.com
- Country
- China
- ProdList
- 2634
- Advantage
- 58
- Tel
- 18130062233
- 3362556465@qq.com
- Country
- China
- ProdList
- 7999
- Advantage
- 58
- Tel
- 027-59101668 19945030958
- Fax
- 027-59101668
- 2881924765@qq.com
- Country
- China
- ProdList
- 8140
- Advantage
- 58
- Tel
- 400-1647117 13681763483
- product02@bidepharm.com
- Country
- China
- ProdList
- 62163
- Advantage
- 58
- Tel
- 13549236410
- sales@invivochem.cn
- Country
- China
- ProdList
- 6753
- Advantage
- 58
- Tel
- +86-027-59232304 15387063101
- 2881924050@qq.com
- Country
- China
- ProdList
- 9951
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24647
- Advantage
- 58
- Tel
- 0371-55013243 15324716602
- 2853979810@qq.com
- Country
- China
- ProdList
- 10018
- Advantage
- 58
- Tel
- 021-69985186 13611928337
- 3427709316@qq.com
- Country
- China
- ProdList
- 7979
- Advantage
- 58
- Tel
- 025-85560043 15850508050
- Fax
- 025-85563444
- cindy.huang@synzest.com
- Country
- China
- ProdList
- 12005
- Advantage
- 58
- Tel
- +86-18521732826
- market@aladdin-e.com
- Country
- China
- ProdList
- 48461
- Advantage
- 58
- Tel
- 17721492509
- 643638326@qq.com
- Country
- China
- ProdList
- 5345
- Advantage
- 58
- Tel
- 17316404525
- 209533805@qq.com
- Country
- China
- ProdList
- 9762
- Advantage
- 58
- Tel
- 18122215013
- 780229652@qq.com
- Country
- China
- ProdList
- 1163
- Advantage
- 58
- Tel
- +undefined-21-51877795
- Fax
- +86 21 5161 9052/ 5187 7796
- ivan@atkchemical.com
- Country
- China
- ProdList
- 32957
- Advantage
- 60
- Tel
- +86-852-30606658
- market18@leapchem.com
- Country
- China
- ProdList
- 43340
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@wheybio.com
- Country
- CHINA
- ProdList
- 4398
- Advantage
- 58
- Tel
- --
- Fax
- --
- WHIGA22@126.COM
- Country
- CHINA
- ProdList
- 6748
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@zzsrm.com
- Country
- CHINA
- ProdList
- 6650
- Advantage
- 58