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COTI-2

Product Name
COTI-2
CAS No.
1039455-84-9
Chemical Name
COTI-2
Synonyms
COTI-2;COTI-2;COTI 2;COTI2;N'-(6,7-Dihydroquinolin-8(5H)-ylidene)-4-(pyridin-2-yl)piperazine-1-carbothiohydrazide;N'-(6,7-Dihydroquinolin-8(5H)-ylidene)-4-(pyridin-2-yl)piperazine-1-carbothiohydrazide;1-Piperazinecarbothioic acid, 4-(2-pyridinyl)-, 2-(6,7-dihydro-8(5H)-quinolinylidene)hydrazide;inhibit,Inhibitor,HNSCC,low,anti-cancer,anti-proliferative,toxicity,TNBC,COTI-2,MDM-2/p53,Apoptosis,orally
CBNumber
CB73165804
Molecular Formula
C19H22N6S
Formula Weight
366.48
MOL File
1039455-84-9.mol
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COTI-2 Property

storage temp. 
2-8°C
solubility 
≤1mg/ml in DMSO;2.5mg/ml in dimethyl formamide
form 
crystalline solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
20031
Product name
COTI-2
Purity
≥95% (E/Z mixture)
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
20031
Product name
COTI-2
Purity
≥95% (E/Z mixture)
Packaging
5mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
20031
Product name
COTI-2
Purity
≥95% (E/Z mixture)
Packaging
10mg
Price
$214
Updated
2024/03/01
Cayman Chemical
Product number
20031
Product name
COTI-2
Purity
≥95% (E/Z mixture)
Packaging
25mg
Price
$456
Updated
2024/03/01
TRC
Product number
C725025
Product name
COTI2
Packaging
25mg
Price
$580
Updated
2021/12/16
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COTI-2 Chemical Properties,Usage,Production

Uses

COTI 2, efficiently inhibits the proliferation rate of all the tested cell lines following 72 h of treatment. COTI-2 is significantly effective at inhibiting tumor cell proliferation in all three cell lines (COLO-205, HCT-15, and SW620).

Biological Activity

coti-2 activates mutant forms of p53.p53 has varoius mechanisms of anticancer function and plays a critical role in genomic stability, apoptosis and inhibition of angiogenesis.

in vitro

previous study tested the efficacy of coti-2 against a diverse group of human cancer cell lines with different genetic mutation backgrounds. results showed that coti-2 efficiently inhibited the proliferation rate of all the tested cell lines following 72 h of treatment. most cell lines showed nanomolar sensitivity to coti-2 treatment. in addition, coti-2 was significantly more effective at inhibiting tumor cell proliferation than either cetuximab or erlotinib in colo-205, hct-15, and sw620 cell lines. notably, all three lines were insensitive to growth inhibition to any degree in response to low concentrations of cetuximab and erlotinib, but highly sensitive to even low doses of coti-2 [1].

in vivo

the effects of coti-2 on inhibiting the growth of ht-29 and shp-77 xenografts in immunocompromised mice was assessed when intraperitoneally administered. it was found that coti-2 at 10 mg/kg could significantly inhibit tumor growth in the ht-29 human colorectal tumor xenografts. in addition to reducing tumor volumes at specific times post-treatment, coti-2 could also delay the time required for tumors to reach specified volumes [1].

References

[1] salim, k. y.,vareki, s.m.,danter, w.r., et al. coti-2, a novel small molecule that is active against multiple human cancer cell lines in vitro and in vivo. oncotarget 7(27), (2016).
[2] https://clinicaltrials. gov/ct2/show/nct02433626term=coti-2&rank=1

COTI-2 Preparation Products And Raw materials

Raw materials

Preparation Products

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1039455-84-9, COTI-2Related Search:


  • COTI-2
  • COTI-2;COTI 2;COTI2
  • 1-Piperazinecarbothioic acid, 4-(2-pyridinyl)-, 2-(6,7-dihydro-8(5H)-quinolinylidene)hydrazide
  • N'-(6,7-Dihydroquinolin-8(5H)-ylidene)-4-(pyridin-2-yl)piperazine-1-carbothiohydrazide
  • inhibit,Inhibitor,HNSCC,low,anti-cancer,anti-proliferative,toxicity,TNBC,COTI-2,MDM-2/p53,Apoptosis,orally
  • N'-(6,7-Dihydroquinolin-8(5H)-ylidene)-4-(pyridin-2-yl)piperazine-1-carbothiohydrazide
  • 1039455-84-9