ChemicalBook > CAS DataBase List > AMG-3969

AMG-3969

Product Name: AMG-3969
CAS No.: 1361224-53-4
Chemical Name: AMG-3969
Synonyms: CS-2503;AMG-3969;AMG-3969, 10 mM in DMSO;AMG-3969; AMG 3969; AMG3969;Hexokinase IV,AMG 3969,Hexokinase D,Glucokinase,Inhibitor,AMG3969,AMG-3969,inhibit;2-[4-[(2S)-4-[(6-amino-3-pyridyl)sulfonyl]-2-prop-1-ynyl-piperazin-1-yl]phenyl]-1,1,1,3,3,3-hexafluoro-propan-2-ol;Benzenemethanol, 4-[(2S)-4-[(6-amino-3-pyridinyl)sulfonyl]-2-(1-propyn-1-yl)-1-piperazinyl]-α,α-bis(trifluoromethyl)-;(S)-2-(4-(4-((6-Aminopyridin-3-yl)sulfonyl)-2-(prop-1-yn-1-yl)piperazin-1-yl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
CBNumber: CB73166063
Molecular Formula: C21H20F6N4O3S
Formula Weight: 522.46
MOL File: 1361224-53-4.mol

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AMG-3969 Property

Boiling point:: 648.8±65.0 °C(Predicted)
Density: 1.56±0.1 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: DMSO:100.0(Max Conc. mg/mL);191.4(Max Conc. mM)
pka: 10.12±0.15(Predicted)
form: Solid
color: White to off-white

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Safety

HS Code: 2935909099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6243
Product name: AMG-3969
Purity: 99.74%
Packaging: 5mg
Price: $420
Updated: 2021/12/16

Apolloscientific

Product number: BISN0048
Product name: AMG-3969
Purity: 99%
Packaging: 5mg
Price: $522
Updated: 2021/12/16

ChemScene

Product number: CS-6243
Product name: AMG-3969
Purity: 99.74%
Packaging: 10mg
Price: $600
Updated: 2021/12/16

Apolloscientific

Product number: BISN0048
Product name: AMG-3969
Purity: 99%
Packaging: 10mg
Price: $747
Updated: 2021/12/16

ChemScene

Product number: CS-6243
Product name: AMG-3969
Purity: 99.74%
Packaging: 1mg
Price: $180
Updated: 2021/12/16

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AMG-3969 Chemical Properties,Usage,Production

Description

AMG-3969is a potent glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor. Itcan strongly boost the dissociation of the GK-GKRP complex and promote GK translocation in-vivo. In rodent model of diabetes, AMG-3969 reduces blood glucose levels without affecting euglycemic animals. It is a promising drug for the treatment of type II diabetes through lowering blood glucose levels with reduced potential for hypoglycaemic risk.

Uses

AMG-3969 is a potent glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor with an IC50 of 4 nM.

in vivo

AMG-3969 has good in vivo pharmacokinetic (PK) properties in rats (75%) and significantly lowers blood glucose levels in a dose-dependent manner db/db mice^[1]. AMG-3969 (100 mg/kg) demonstrates significant reductions in blood glucose with robust efficacy (56% reduction) observed at the 8 h time point^[2]. AMG-3969 demonstrates dose-dependent efficacy in three models of diabetes: diet induced obese (DIO), ob/ob and db/db mice; however,AMG-3969 is ineffective in lowering blood glucose in normoglycaemic C57BL/6 (B6) mice. AMG-3969 is highly effective in promoting carbohydrate substrate. AMG-3969 exhibits extended changes to carbohydrate oxidation as observed by increased respiratory exchange ratio into the next night and day after a single dose^[3].

References

Lloyd, David J., et al. "Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors." Nature 504.7480(2013):437-40.
Bourbeau, M. P., et al. "Nonracemic synthesis of GK-GKRP disruptor AMG-3969. " Synfacts 79.8(2014):3684.
http://www.metonchem.com/products/amg-3969-cas1361224-53-4/

AMG-3969 Preparation Products And Raw materials

Raw materials

Preparation Products

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AMG-3969 Suppliers

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1361224-53-4, AMG-3969Related Search:

AMG-3969

CS-2503

AMG-3969; AMG 3969; AMG3969

Benzenemethanol, 4-[(2S)-4-[(6-amino-3-pyridinyl)sulfonyl]-2-(1-propyn-1-yl)-1-piperazinyl]-α,α-bis(trifluoromethyl)-

(S)-2-(4-(4-((6-Aminopyridin-3-yl)sulfonyl)-2-(prop-1-yn-1-yl)piperazin-1-yl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

Hexokinase IV,AMG 3969,Hexokinase D,Glucokinase,Inhibitor,AMG3969,AMG-3969,inhibit

2-[4-[(2S)-4-[(6-amino-3-pyridyl)sulfonyl]-2-prop-1-ynyl-piperazin-1-yl]phenyl]-1,1,1,3,3,3-hexafluoro-propan-2-ol

AMG-3969, 10 mM in DMSO

1361224-53-4

C21H20F6N4O3S