AMG-3969

ChemicalBook > CAS DataBase List > AMG-3969

Product Name: AMG-3969
CAS No.: 1361224-53-4
Chemical Name: AMG-3969
Synonyms: CS-2503;AMG-3969;AMG-3969; AMG 3969; AMG3969;Hexokinase IV,AMG 3969,Hexokinase D,Glucokinase,Inhibitor,AMG3969,AMG-3969,inhibit;2-[4-[(2S)-4-[(6-amino-3-pyridyl)sulfonyl]-2-prop-1-ynyl-piperazin-1-yl]phenyl]-1,1,1,3,3,3-hexafluoro-propan-2-ol;Benzenemethanol, 4-[(2S)-4-[(6-amino-3-pyridinyl)sulfonyl]-2-(1-propyn-1-yl)-1-piperazinyl]-α,α-bis(trifluoromethyl)-;Benzenemethanol, 4-[(2S)-4-[(6-amino-3-pyridinyl)sulfonyl]-2-(1-propyn-1-yl)-1-piperazinyl]-α,α-bis(trifluoromethyl)-;(S)-2-(4-(4-((6-Aminopyridin-3-yl)sulfonyl)-2-(prop-1-yn-1-yl)piperazin-1-yl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
CBNumber: CB73166063
Molecular Formula: C21H20F6N4O3S
Formula Weight: 522.46
MOL File: 1361224-53-4.mol

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AMG-3969 Property

Boiling point:: 648.8±65.0 °C(Predicted)
Density: 1.56±0.1 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: DMSO:100.0(Max Conc. mg/mL);191.4(Max Conc. mM)
pka: 10.12±0.15(Predicted)
form: Solid
color: White to off-white

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Safety

HS Code: 2935909099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6243
Product name: AMG-3969
Purity: 99.74%
Packaging: 5mg
Price: $420
Updated: 2021/12/16

Apolloscientific

Product number: BISN0048
Product name: AMG-3969
Purity: 99%
Packaging: 5mg
Price: $522
Updated: 2021/12/16

ChemScene

Product number: CS-6243
Product name: AMG-3969
Purity: 99.74%
Packaging: 10mg
Price: $600
Updated: 2021/12/16

Apolloscientific

Product number: BISN0048
Product name: AMG-3969
Purity: 99%
Packaging: 10mg
Price: $747
Updated: 2021/12/16

ChemScene

Product number: CS-6243
Product name: AMG-3969
Purity: 99.74%
Packaging: 1mg
Price: $180
Updated: 2021/12/16

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AMG-3969 Chemical Properties,Usage,Production

Description

AMG-3969is a potent glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor. Itcan strongly boost the dissociation of the GK-GKRP complex and promote GK translocation in-vivo. In rodent model of diabetes, AMG-3969 reduces blood glucose levels without affecting euglycemic animals. It is a promising drug for the treatment of type II diabetes through lowering blood glucose levels with reduced potential for hypoglycaemic risk.

References

Lloyd, David J., et al. "Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors." Nature 504.7480(2013):437-40.
Bourbeau, M. P., et al. "Nonracemic synthesis of GK-GKRP disruptor AMG-3969. " Synfacts 79.8(2014):3684.
http://www.metonchem.com/products/amg-3969-cas1361224-53-4/

AMG-3969 Preparation Products And Raw materials

Raw materials

Preparation Products

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1361224-53-4, AMG-3969Related Search:

AMG-3969

CS-2503

AMG-3969; AMG 3969; AMG3969

Benzenemethanol, 4-[(2S)-4-[(6-amino-3-pyridinyl)sulfonyl]-2-(1-propyn-1-yl)-1-piperazinyl]-α,α-bis(trifluoromethyl)-

(S)-2-(4-(4-((6-Aminopyridin-3-yl)sulfonyl)-2-(prop-1-yn-1-yl)piperazin-1-yl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

Hexokinase IV,AMG 3969,Hexokinase D,Glucokinase,Inhibitor,AMG3969,AMG-3969,inhibit

2-[4-[(2S)-4-[(6-amino-3-pyridyl)sulfonyl]-2-prop-1-ynyl-piperazin-1-yl]phenyl]-1,1,1,3,3,3-hexafluoro-propan-2-ol

1361224-53-4

C21H20F6N4O3S