6,7-dihydro-2H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3(5H)-one

Product Name: 6,7-dihydro-2H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3(5H)-one
CAS No.: 25823-52-3
Chemical Name: 6,7-dihydro-2H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3(5H)-one
Synonyms: CPD3615-B4;2,5,6,7-tetrahydrobenzo[1,2]cyclohepta[4,6-d]pyridazin-3-one;6,7-dihydro-2H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3(5H)-one;3H-Benzo[6,7]cyclohepta[1,2-c]pyridazin-3-one, 2,5,6,7-tetrahydro-;CPD3615-B4/6,7-Dihydro-2H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3(5H)-one
CBNumber: CB73171283
Molecular Formula: C13H12N2O
Formula Weight: 212.25
MOL File: 25823-52-3.mol

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6,7-dihydro-2H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3(5H)-one Property

Melting point:: 243 °C
Density: 1.30±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 10.37±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Ambeed

Product number: A221108
Product name: 6,7-Dihydro-2H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3(5H)-one
Purity: 95%
Packaging: 100mg
Price: $73
Updated: 2021/12/16

Ambeed

Product number: A221108
Product name: 6,7-Dihydro-2H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3(5H)-one
Purity: 95%
Packaging: 250mg
Price: $145
Updated: 2021/12/16

Aaron Chemicals

Product number: AR00I5ME
Product name: 3H-Benzo[6,7]cyclohepta[1,2-c]pyridazin-3-one,2,5,6,7-tetrahydro-
Purity: 95%
Packaging: 100mg
Price: $238
Updated: 2021/12/16

Crysdot

Product number: CD11157639
Product name: 6,7-Dihydro-2H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3(5H)-one
Purity: 95+%
Packaging: 250mg
Price: $293
Updated: 2021/12/16

Ambeed

Product number: A221108
Product name: 6,7-Dihydro-2H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3(5H)-one
Purity: 95%
Packaging: 1g
Price: $382
Updated: 2021/12/16

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6,7-dihydro-2H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3(5H)-one Chemical Properties,Usage,Production

Synthesis

25742-87-4

25823-52-3

Using 4a,5,6,7-tetrahydro-2H-benzo[6,7]cyclohepta[c]pyridazin-3(4H)-one (4.7 g, 22 mmol) as starting material, it was mixed with anhydrous copper(II) chloride (6 g, 44 mmol) in acetonitrile (45 mL) and the reaction was carried out at reflux for 2 hours. After completion of the reaction, the mixture was cooled to room temperature and subsequently poured into ice water (200 g). The resulting solid was washed sequentially by 10% hydrochloric acid solution (~20 mL x 2) and cold water (~20 mL x 2). After freeze-drying treatment, the target product 3-oxo-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazine (4.2 g, 90% yield) was obtained as a white solid. The product was characterized by 1H NMR (300 MHz, CDCl3): δ 10.80 (broad single peak, 1H), 7.53-7.21 (multiple peaks, 4H), 6.77 (single peak, 1H), 2.66 (triple peak, J = 6.9 Hz, 2H), 2.45 (triple peak, J = 6.9 Hz, 2H), 2.14 (quadruple peak, J = 6.9 Hz. 2H).LC-MS analysis showed 100% purity, mass spectrum (m/e): 213 (MH+).

References

[1] Patent: WO2008/83353, 2008, A1. Location in patent: Page/Page column 126
[2] Patent: WO2008/83367, 2008, A2. Location in patent: Page/Page column 137
[3] Patent: WO2010/5876, 2010, A2. Location in patent: Page/Page column 60-61
[4] Patent: WO2008/83353, 2008, A1. Location in patent: Page/Page column 126-127
[5] Patent: WO2008/83367, 2008, A2. Location in patent: Page/Page column 137-138

6,7-dihydro-2H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3(5H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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6,7-dihydro-2H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3(5H)-one Suppliers

China 19 India 2 United States 2 Global 23

Chembest Research Laboratories Limited

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Nanjing Meihao Pharmaceutical Technology Co., Ltd.

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Labnetwork lnc.

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Block Chemical Technology (Shanghai) Co., LTD

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Shanghai Kaiwei Chemical Technology Co., Ltd.

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25823-52-3, 6,7-dihydro-2H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3(5H)-oneRelated Search:

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