Mirogabalin besylate

Product Name: Mirogabalin besylate
CAS No.: 1138245-21-2
Chemical Name: Mirogabalin besylate
Synonyms: Mirogabalin Besilate;Mirogabalin besylat;Mirogabalin besylate;Mirogabalin Besylate 10928;Milobarin ptoluenesulfonate;Linagliptin Impurity CD10126;Milo Bahrain benzenesulfonate;Mirogabalin besylate (DS-5565;MIROGABALIN BENZENESULFONIC ACID;Mirogabalin besylate (DS 5565 besylate)
CBNumber: CB73175483
Molecular Formula: C18H25NO5S
Formula Weight: 367.46
MOL File: 1138245-21-2.mol

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Mirogabalin besylate Property

storage temp.: Store at -20°C
solubility: DMSO : 125 mg/mL (340.17 mM)
form: Solid
color: White to off-white
InChI: InChI=1/C12H19NO2.C6H6O3S/c1-2-8-3-9-5-12(7-13,6-11(14)15)10(9)4-8;7-10(8,9)6-4-2-1-3-5-6/h4,9-10H,2-3,5-7,13H2,1H3,(H,14,15);1-5H,(H,7,8,9)/t9-,10-,12-;/s3
InChIKey: OKJXJRVWXYRSAN-QWGAVYBYNA-N
SMILES: S(C1C=CC=CC=1)(O)(=O)=O.C([C@]1(C[C@@]2([H])CC(CC)=C[C@@]12[H])CN)C(=O)O |&1:11,13,20,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0027136
Product name: Mirogabalinbesylate
Purity: 99.98%
Packaging: 5mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-0027136
Product name: Mirogabalinbesylate
Purity: 99.98%
Packaging: 10mg
Price: $190
Updated: 2021/12/16

ChemScene

Product number: CS-0027136
Product name: Mirogabalinbesylate
Purity: 99.98%
Packaging: 50mg
Price: $490
Updated: 2021/12/16

ChemScene

Product number: CS-0027136
Product name: Mirogabalinbesylate
Purity: 99.98%
Packaging: 100mg
Price: $750
Updated: 2021/12/16

DC Chemicals

Product number: DC10532
Product name: Mirogabalinbesylate
Purity: >98%
Packaging: 250mg
Price: $900
Updated: 2021/12/16

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Mirogabalin besylate Chemical Properties,Usage,Production

Description

Mirogabalin besylate (mirogabalin, Tarlige) is a gabapentinoid therapy developed by Daiichi Sankyo, which is approved in Japan for the treatment of postherpetic neuralgia and painful diabetic peripheral neuropathy. Mirogabalin has a potent pain-modulating effect with a unique high affinity and prolonged dissociation rate for the a2delta-1 subunit of voltage-gated calcium (Ca2+) channels (VGCCs) on the dorsal root ganglion resulting in more sustained analgesia compared with traditional gabapentinoids[1].

Uses

Mirogabalin besylate is an oral gabapentin analogue for the treatment of peripheral neuralgia (PNP), including diabetic PNP and postherpetic neuralgia. The drug has been approved in Japan for the treatment of PNP and has not yet received FDA approval.

brand name

Tarlige

Mechanism of action

Mirogabalin besylate selectively and potently binds to the α2δ subunit of voltage-gated calcium channels. When mirogabalin is bound, the influx of calcium ions to the presynaptic terminal is reduced, thereby inhibiting the release of excitatory neurotransmitters and providing analgesic effects.

Side effects

Mirogabalin has a superior adverse events (AEs) profile due to a rapid dissociation from the a2delta-2 subunit of VGCCs potentially implicated in central nervous system-specific AEs. The most common AEs for mirogabalin are dizziness (approximately 8-16%), somnolence (approximately 6-24%) and headache (approximately 6-14%), with a lower incidence of constipation, nausea, diarrhea, vomiting, edema, fatigue and weight gain[1].

Synthesis

Synthesis of Mirogabalin besylate

Metabolism

Mirogabalin is rapidly absorbed, and clearance is through renal excretion (approximately 80%) with approximately 20% being metabolized. Metabolism is primarily to the biologically inactive14 lactam form (A204-4455) and involves various uridine 5′-diphospho-glucuronosyltransferase (UGT) isoforms acting at the carboxylic acid moiety to produce mirogabalin acylglucuronide, which is then nonenzymatically converted to A204-4455.

References

[1] J Burgess. “Mirogabalin besylate in the treatment of neuropathic pain.” Drugs of today 56 2 (2020): 135–149.

Mirogabalin besylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Mirogabalin besylate Suppliers

China 180 India 7 United States 3 Global 190

Shandong Risen-Sun Pharmaceutical Co., Ltd.

Tel: +86-0538-8923092 13958575904
Email: risensun-sales@jewim.com.cn
Country: China
ProdList: 40
Advantage: 58

Nanjing Tianhai Pharmaceutical Technology Co., Ltd.

Tel: 025-58351158 13851454004
Fax: 025-83271564
Email: 3494688757@qq.com
Country: China
ProdList: 297
Advantage: 58

Nanjing Vcare PharmaTech Co., Ltd

Tel: 025-58741518 13327700685
Email: sales@vcarepharmatech.com
Country: China
ProdList: 487
Advantage: 58

Taizhou Yuxin Biotechnology Co., Ltd.,

Tel: +86-0576--88902229 +86-13968687450
Email: yuxin@yuxchem.com
Country: China
ProdList: 262
Advantage: 58

SuZhou Medinoah Co.,LTD.

Tel: 0512-69561983 13914027025
Fax: 0512-69561982
Email: zhang_q@medinoah.com
Country: China
ProdList: 3893
Advantage: 58

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 15000803246 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 457
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Email: cangzhoukangrui@126.com;355803330@qq.com
Country: China
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Cangzhou Enke Pharma Tech Co.,ltd.

Tel: 0317-5106596 15533709196
Email: 1154424302@qq.com
Country: China
ProdList: 2361
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Nanjing Lebang Pharmaceutical Technology Co., Ltd

Tel: 18860950986
Email: tangmanman@lebangpharma.com
Country: China
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Shanghai Hope Chem Co., Ltd.，

Tel: +21-18501659228 18501659228
Fax: sales@hope-chem.com
Email: info@hope-chem.com
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Advantage: 55

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View Lastest Price from Mirogabalin besylate manufacturers

Rongchuang International

Product: Mirogabalin besylate 1138245-21-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 99999
Release date: 2026-03-24

Shandong Hanjiang Chemical Co., Ltd

Product: Mirogabalin besylate 1138245-21-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1T
Release date: 2026-01-28

RongNa Biotechnology Co.,Ltd

Product: Mirogabalin Besylate 1138245-21-2
Price: US $10.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 99%
Supply Ability: 1 ton
Release date: 2026-01-06

1138245-21-2, Mirogabalin besylateRelated Search:

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Mirogabalin Besylate 10928

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Linagliptin Impurity CD10126

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Mirogabalin Besilate

1138245-21-2

181816-66-8