Mirogabalin besylate

Product Name: Mirogabalin besylate
CAS No.: 1138245-21-2
Chemical Name: Mirogabalin besylate
Synonyms: Mirogabalin Besilate;Mirogabalin besylat;Mirogabalin besylate;Mirogabalin Besylate 10928;MIROGABALIN BENZENESULFONIC ACID;Mirogabalin besylate (DS 5565 besylate);2-((1R,5S,6S)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetic acid besylate;[(1R,5S,6S)-6-(Aminomethyl)-3-ethylbicyclo[3.2.0] hept-3-en-6-yl]acetic acid benzenesulfonate;((1R,5S,6S)-6-(carboxymethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)methanaminium benzenesulfonate;2-((1R,5S,6S)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetic acid compound with benzenesulfonic acid (1:1)
CBNumber: CB73175483
Molecular Formula: C18H25NO5S
Formula Weight: 367.46
MOL File: 1138245-21-2.mol

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Mirogabalin besylate Property

storage temp.: Store at -20°C
solubility: DMSO : 125 mg/mL (340.17 mM)
InChI: InChI=1/C12H19NO2.C6H6O3S/c1-2-8-3-9-5-12(7-13,6-11(14)15)10(9)4-8;7-10(8,9)6-4-2-1-3-5-6/h4,9-10H,2-3,5-7,13H2,1H3,(H,14,15);1-5H,(H,7,8,9)/t9-,10-,12-;/s3
InChIKey: OKJXJRVWXYRSAN-QWGAVYBYNA-N
SMILES: S(C1C=CC=CC=1)(O)(=O)=O.C([C@]1(C[C@@]2([H])CC(CC)=C[C@@]12[H])CN)C(=O)O |&1:11,13,20,r|

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0027136
Product name: Mirogabalinbesylate
Purity: 99.98%
Packaging: 5mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-0027136
Product name: Mirogabalinbesylate
Purity: 99.98%
Packaging: 10mg
Price: $190
Updated: 2021/12/16

ChemScene

Product number: CS-0027136
Product name: Mirogabalinbesylate
Purity: 99.98%
Packaging: 50mg
Price: $490
Updated: 2021/12/16

ChemScene

Product number: CS-0027136
Product name: Mirogabalinbesylate
Purity: 99.98%
Packaging: 100mg
Price: $750
Updated: 2021/12/16

DC Chemicals

Product number: DC10532
Product name: Mirogabalinbesylate
Purity: >98%
Packaging: 250mg
Price: $900
Updated: 2021/12/16

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Mirogabalin besylate Chemical Properties,Usage,Production

Description

Mirogabalin besylate (mirogabalin, Tarlige) is a gabapentinoid therapy developed by Daiichi Sankyo, which is approved in Japan for the treatment of postherpetic neuralgia and painful diabetic peripheral neuropathy. Mirogabalin has a potent pain-modulating effect with a unique high affinity and prolonged dissociation rate for the a2delta-1 subunit of voltage-gated calcium (Ca2+) channels (VGCCs) on the dorsal root ganglion resulting in more sustained analgesia compared with traditional gabapentinoids[1].

Side effects

Mirogabalin has a superior adverse events (AEs) profile due to a rapid dissociation from the a2delta-2 subunit of VGCCs potentially implicated in central nervous system-specific AEs. The most common AEs for mirogabalin are dizziness (approximately 8-16%), somnolence (approximately 6-24%) and headache (approximately 6-14%), with a lower incidence of constipation, nausea, diarrhea, vomiting, edema, fatigue and weight gain[1].

References

[1] J Burgess. “Mirogabalin besylate in the treatment of neuropathic pain.” Drugs of today 56 2 (2020): 135–149.

Mirogabalin besylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Mirogabalin besylate Suppliers

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1138245-21-2, Mirogabalin besylateRelated Search:

Mirogabalin besylate

Mirogabalin besylat

Mirogabalin Besilate

MIROGABALIN BENZENESULFONIC ACID

((1R,5S,6S)-6-(carboxymethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)methanaminium benzenesulfonate

[(1R,5S,6S)-6-(Aminomethyl)-3-ethylbicyclo[3.2.0] hept-3-en-6-yl]acetic acid benzenesulfonate

2-((1R,5S,6S)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetic acid compound with benzenesulfonic acid (1:1)

Mirogabalin Besylate 10928

Mirogabalin besylate (DS 5565 besylate)

2-((1R,5S,6S)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetic acid besylate

1138245-21-2