Mirogabalin besylate

Product Name: Mirogabalin besylate
CAS No.: 1138245-21-2
Chemical Name: Mirogabalin besylate
Synonyms: Mirogabalin Besilate;Mirogabalin besylat;Mirogabalin besylate;Mirogabalin Besylate 10928;Linagliptin Impurity CD10126;MIROGABALIN BENZENESULFONIC ACID;Mirogabalin besylate (DS 5565 besylate);2-((1R,5S,6S)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetic acid besylate;[(1R,5S,6S)-6-(Aminomethyl)-3-ethylbicyclo[3.2.0] hept-3-en-6-yl]acetic acid benzenesulfonate;((1R,5S,6S)-6-(carboxymethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)methanaminium benzenesulfonate
CBNumber: CB73175483
Molecular Formula: C18H25NO5S
Formula Weight: 367.46
MOL File: 1138245-21-2.mol

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Mirogabalin besylate Property

storage temp.: Store at -20°C
solubility: DMSO : 125 mg/mL (340.17 mM)
form: Solid
color: White to off-white
InChI: InChI=1/C12H19NO2.C6H6O3S/c1-2-8-3-9-5-12(7-13,6-11(14)15)10(9)4-8;7-10(8,9)6-4-2-1-3-5-6/h4,9-10H,2-3,5-7,13H2,1H3,(H,14,15);1-5H,(H,7,8,9)/t9-,10-,12-;/s3
InChIKey: OKJXJRVWXYRSAN-QWGAVYBYNA-N
SMILES: S(C1C=CC=CC=1)(O)(=O)=O.C([C@]1(C[C@@]2([H])CC(CC)=C[C@@]12[H])CN)C(=O)O |&1:11,13,20,r|

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0027136
Product name: Mirogabalinbesylate
Purity: 99.98%
Packaging: 5mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-0027136
Product name: Mirogabalinbesylate
Purity: 99.98%
Packaging: 10mg
Price: $190
Updated: 2021/12/16

ChemScene

Product number: CS-0027136
Product name: Mirogabalinbesylate
Purity: 99.98%
Packaging: 50mg
Price: $490
Updated: 2021/12/16

ChemScene

Product number: CS-0027136
Product name: Mirogabalinbesylate
Purity: 99.98%
Packaging: 100mg
Price: $750
Updated: 2021/12/16

DC Chemicals

Product number: DC10532
Product name: Mirogabalinbesylate
Purity: >98%
Packaging: 250mg
Price: $900
Updated: 2021/12/16

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Mirogabalin besylate Chemical Properties,Usage,Production

Description

Mirogabalin besylate (mirogabalin, Tarlige) is a gabapentinoid therapy developed by Daiichi Sankyo, which is approved in Japan for the treatment of postherpetic neuralgia and painful diabetic peripheral neuropathy. Mirogabalin has a potent pain-modulating effect with a unique high affinity and prolonged dissociation rate for the a2delta-1 subunit of voltage-gated calcium (Ca2+) channels (VGCCs) on the dorsal root ganglion resulting in more sustained analgesia compared with traditional gabapentinoids[1].

Uses

Mirogabalin besylate is an oral gabapentin analogue for the treatment of peripheral neuralgia (PNP), including diabetic PNP and postherpetic neuralgia. The drug has been approved in Japan for the treatment of PNP and has not yet received FDA approval.

Side effects

Mirogabalin has a superior adverse events (AEs) profile due to a rapid dissociation from the a2delta-2 subunit of VGCCs potentially implicated in central nervous system-specific AEs. The most common AEs for mirogabalin are dizziness (approximately 8-16%), somnolence (approximately 6-24%) and headache (approximately 6-14%), with a lower incidence of constipation, nausea, diarrhea, vomiting, edema, fatigue and weight gain[1].

References

[1] J Burgess. “Mirogabalin besylate in the treatment of neuropathic pain.” Drugs of today 56 2 (2020): 135–149.

Mirogabalin besylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Mirogabalin besylate Suppliers

China 126 India 7 United States 3 Global 136

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View Lastest Price from Mirogabalin besylate manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Mirogabalin Besylate 1138245-21-2
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-07-24

1138245-21-2, Mirogabalin besylateRelated Search:

Mirogabalin besylate

Mirogabalin besylat

Mirogabalin Besilate

MIROGABALIN BENZENESULFONIC ACID

((1R,5S,6S)-6-(carboxymethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)methanaminium benzenesulfonate

[(1R,5S,6S)-6-(Aminomethyl)-3-ethylbicyclo[3.2.0] hept-3-en-6-yl]acetic acid benzenesulfonate

2-((1R,5S,6S)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetic acid compound with benzenesulfonic acid (1:1)

Mirogabalin Besylate 10928

Mirogabalin besylate (DS 5565 besylate)

2-((1R,5S,6S)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetic acid besylate

Linagliptin Impurity CD10126

1138245-21-2