RWJ 63556

Product Name: RWJ 63556
CAS No.: 190967-35-2
Chemical Name: RWJ 63556
Synonyms: RWJ 63556;RWJ 63556, 10 mM in DMSO;Methanesulfonamide, N-[5-(4-fluorophenoxy)-2-thienyl]-
CBNumber: CB73175579
Molecular Formula: C11H10FNO3S2
Formula Weight: 287.33
MOL File: 190967-35-2.mol

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RWJ 63556 Property

Boiling point:: 403.4±55.0 °C(Predicted)
Density: 1.479±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
pka: 8.60±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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RWJ 63556 Chemical Properties,Usage,Production

Uses

RWJ 63556 is an orally active COX-2 selective/5-lipoxygenase inhibitor, with anti-inflammatory activities.

in vivo

RWJ 63556 (1?mg/kg, i.v.) significantly inhibits the development of SP-induced oedema^[2].

IC 50

COX-2; 5-Lipoxygenase

References

[1] Kirchner T, et al. Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor, RWJ 63556, in a canine model of inflammation. J Pharmacol Exp Ther. 1997 Aug;282(2):1094-101. PMID:9262379
[2] Le Filliatre G, et al. Cyclo-oxygenase and lipoxygenase pathways in mast cell dependent-neurogenic inflammation induced by electrical stimulation of the rat saphenous nerve. Br J Pharmacol. 2001 Apr;132(7):1581-9. DOI:10.1038/sj.bjp.0703950

RWJ 63556 Preparation Products And Raw materials

Raw materials

Preparation Products

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RWJ 63556 Suppliers

China 12 United States 2 Global 14

Fan De(Beijing) Biotechnology Co., Ltd.

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Proteintech China

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190967-35-2, RWJ 63556Related Search:

RWJ 63556

Methanesulfonamide, N-[5-(4-fluorophenoxy)-2-thienyl]-

RWJ 63556, 10 mM in DMSO

190967-35-2

C11H10FNO3S2