2-ACETYL-4,5-DICHLOROTHIOPHENE

Product Name: 2-ACETYL-4,5-DICHLOROTHIOPHENE
CAS No.: 57681-59-1
Chemical Name: 2-ACETYL-4,5-DICHLOROTHIOPHENE
Synonyms: AKOS 91935;Chlorphenamine Impurity 21;2-ACETYL-4,5-DICHLOROTHIOPHENE;1-(4,5-Dichloro-2-thienyl)ethanone;2-Acetyl-4,5-dichlorothiophene 1-(4,5-Dichlorothiophen-2-yl)ethanone;Ethanone, 1-(4,5-dichloro-2-thienyl)-;1-(4,5-Dichlorothiophen-2-yl)ethan-1-one
CBNumber: CB7324439
Molecular Formula: C6H4Cl2OS
Formula Weight: 195.07
MOL File: 57681-59-1.mol

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2-ACETYL-4,5-DICHLOROTHIOPHENE Property

Melting point:: 68 °C
Boiling point:: 300.8±42.0 °C(Predicted)
Density: 1.452±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
Appearance: Off-white to pink Solid

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36/37/39

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FA147878
Product name: 2-Acetyl-4,5-dichlorothiophene
Packaging: 250mg
Price: $85
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA147878
Product name: 2-Acetyl-4,5-dichlorothiophene
Packaging: 500mg
Price: $145
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA147878
Product name: 2-Acetyl-4,5-dichlorothiophene
Packaging: 1g
Price: $255
Updated: 2021/12/16

AK Scientific

Product number: 0442CB
Product name: 2-Acetyl-4,5-dichlorothiophene
Packaging: 1g
Price: $394
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA147878
Product name: 2-Acetyl-4,5-dichlorothiophene
Packaging: 2g
Price: $444
Updated: 2021/12/16

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2-ACETYL-4,5-DICHLOROTHIOPHENE Chemical Properties,Usage,Production

Synthesis

17249-79-5

68-12-2

57681-59-1

At -78 °C, n-butyllithium (2.51 g, 39.2 mmol, 24.5 mL) was slowly added dropwise to a stirred solution of diisopropylamine (3.97 g, 39.2 mmol, 5.54 mL) in tetrahydrofuran (5 mL) with continuous stirring for 45 min to generate lithium diisopropylamine (LDA) in situ. Subsequently, 2,3-dichlorothiophene (5 g, 32.7 mmol) dissolved in tetrahydrofuran (5 mL) was added dropwise and stirring was continued for 30 min at -78 °C. Next, N,N-dimethylformamide (3.41 g, 39.2 mmol, 3.64 mL) dissolved in tetrahydrofuran (5 mL) was added dropwise and the mixture was stirred at the same temperature for another 30 min. The cooling bath was removed and the reaction mixture was allowed to slowly warm up to room temperature. Upon completion of the reaction, the reaction was quenched with acetic acid/methanol (4 mL each) and stirred at room temperature for 15 minutes. The reaction mixture was diluted with ethyl acetate (50 mL) and washed sequentially with saturated aqueous sodium bicarbonate (25 mL), deionized water (25 mL) and saturated aqueous sodium chloride (25 mL). The organic layer was dried over anhydrous sodium sulfate (500 mg), and the desiccant was removed by filtration through crude glassine, followed by concentration under reduced pressure to give a white solid (9 g). The crude product was purified by fast column chromatography (eluent: EtOAc/hexane) to afford 2-acetyl-4,5-dichlorothiophene as a white powder (6.34 g, 19% yield). Mass spectrometry analysis showed a molecular ion peak (M + H)+ of 195.

References

[1] Patent: WO2006/66172, 2006, A1. Location in patent: Page/Page column 33-34

2-ACETYL-4,5-DICHLOROTHIOPHENE Preparation Products And Raw materials

Raw materials

Preparation Products

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57681-59-1, 2-ACETYL-4,5-DICHLOROTHIOPHENERelated Search:

3-ACETYL-2,5-DICHLOROTHIOPHENE,3-ACETYL-2,5-DICHLOROTHIOPHENE,98+% CHEMBRDG-BB 6539802 2-ACETYL-4,5-DICHLOROTHIOPHENE AKOS 91920 AKOS 232-01 AKOS 93095 2-CHLORO-1-(4,5-DICHLORO-2-THIENYL)ETHAN-1-ONE

2-ACETYL-4,5-DICHLOROTHIOPHENE

AKOS 91935

Ethanone, 1-(4,5-dichloro-2-thienyl)-

1-(4,5-Dichlorothiophen-2-yl)ethanone

2-Acetyl-4,5-dichlorothiophene&nbsp

1-(4,5-Dichlorothiophen-2-yl)ethan-1-one

1-(4,5-Dichloro-2-thienyl)ethanone

Chlorphenamine Impurity 21

57681-59-1

5768-59-1

Intermediate