ChemicalBook > CAS DataBase List > 2-AMINO-5,6-DIHYDRO-1,3-BENZOTHIAZOL-7(4H)-ONE

2-AMINO-5,6-DIHYDRO-1,3-BENZOTHIAZOL-7(4H)-ONE

Product Name
2-AMINO-5,6-DIHYDRO-1,3-BENZOTHIAZOL-7(4H)-ONE
CAS No.
17583-10-7
Chemical Name
2-AMINO-5,6-DIHYDRO-1,3-BENZOTHIAZOL-7(4H)-ONE
Synonyms
IFLAB-BB F1303-0001;3-BENZOTHIAZOL-7(4H)-ONE;2-AMINO-5,6-DIHYDRO-4H-BENZOTHIAZOL-7-ONE;2-Amino-5,6-dihydrobenzothiazol-7(4H)-one;2-amino-5,6-dihydro-7(4H)-Benzothiazolone;7(4H)-Benzothiazolone, 2-aMino-5,6-dihydro-;2-amino-5,6-dihydrobenzo[d]thiazol-7(4H)-one;2-amino-5,6-dihydro-4H-1,3-benzothiazol-7-one;2-AMINO-5,6-DIHYDRO-1,3-BENZOTHIAZOL-7(4H)-ONE;2-Amino-5,6-Dihydro-4H-Benzothiazol-7-One(WX140896)
CBNumber
CB7325289
Molecular Formula
C7H8N2OS
Formula Weight
168.22
MOL File
17583-10-7.mol
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2-AMINO-5,6-DIHYDRO-1,3-BENZOTHIAZOL-7(4H)-ONE Property

Melting point:
269-270 °C(Solv: ethyl acetate (141-78-6))
Boiling point:
376.0±11.0 °C(Predicted)
Density 
1.428±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
DMSO (Sparingly)
form 
Solid
pka
3.36±0.20(Predicted)
color 
Light Yellow
InChI
InChI=1S/C7H8N2OS/c8-7-9-4-2-1-3-5(10)6(4)11-7/h1-3H2,(H2,8,9)
InChIKey
JAZOMJIYYHHUBH-UHFFFAOYSA-N
SMILES
S1C2C(=O)CCCC=2N=C1N
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
22
HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
A597090
Product name
2-Amino-5,6-dihydro-4h-benzothiazol-7-one
Packaging
1g
Price
$115
Updated
2021/12/16
Usbiological
Product number
415308
Product name
2-Amino-5,6-dihydro-4h-benzothiazol-7-one
Packaging
100mg
Price
$305
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA13110
Product name
2-Amino-5,6-dihydro-4H-benzothiazol-7-one
Packaging
1g
Price
$367.5
Updated
2021/12/16
Matrix Scientific
Product number
010114
Product name
2-Amino-5,6-dihydro-4H-benzothiazol-7-one
Purity
95%
Packaging
5g
Price
$110
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA13110
Product name
2-Amino-5,6-dihydro-4H-benzothiazol-7-one
Packaging
500mg
Price
$265
Updated
2021/12/16
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2-AMINO-5,6-DIHYDRO-1,3-BENZOTHIAZOL-7(4H)-ONE Chemical Properties,Usage,Production

Synthesis

60060-44-8

17356-08-0

17583-10-7

Step ii: Synthesis of 2-amino-5,6-dihydrobenzo[d]thiazol-7(4H)-one To a 100 mL round bottom flask was added 2-bromo-1,3-cyclohexanedione (1.0 g, 5.23 mmol) and methanol (15 mL). Subsequently, thiourea (0.397 g, 5.23 mmol) and pyridine (0.412 g, 5.23 mmol) were added to the same flask. The reaction mixture was heated to reflux temperature and stirred for 4 hours. After completion of the reaction, the volatile solvent was removed by distillation under reduced pressure to give the crude product. The crude product was dissolved in water and stirred for 5 min to promote the formation of precipitate. The precipitate was collected by filtration and washed with distilled water to give the final 2-amino-5,6-dihydrobenzo[d]thiazol-7(4H)-one (0.8 g, 91% yield). Product characterization data: 1H NMR (300 MHz, DMSO-d6): δ 8.12 (brs, 2H), 2.69 (t, 2H), 2.38 (t, 2H), 2.02 (m, 2H). LC-MS (ESI): m/z 168.9 [M + H]+.

References

[1] Patent: WO2015/101928, 2015, A1. Location in patent: Page/Page column 100
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 5, p. 2136 - 2145
[3] Pharmaceutical Chemistry Journal, 1993, vol. 27, # 7, p. 500 - 503
[4] Khimiko-Farmatsevticheskii Zhurnal, 1993, vol. 27, # 7, p. 37 - 39
[5] Patent: WO2005/5438, 2005, A1. Location in patent: Page/Page column 36

2-AMINO-5,6-DIHYDRO-1,3-BENZOTHIAZOL-7(4H)-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-AMINO-5,6-DIHYDRO-1,3-BENZOTHIAZOL-7(4H)-ONE Suppliers

Canada 2 China 104 France 1 Germany 1 India 2 Russia 1 United Kingdom 2 United States 11 Global 124
Interchim S.A.
Tel
--
Fax
--
Email
interchim@interchim.com
Country
France
ProdList
6302
Advantage
76
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View Lastest Price from 2-AMINO-5,6-DIHYDRO-1,3-BENZOTHIAZOL-7(4H)-ONE manufacturers

Career Henan Chemical Co
Product
2-AMINO-5,6-DIHYDRO-1,3-BENZOTHIAZOL-7(4H)-ONE 17583-10-7
Price
US $6.68/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg-1000kg
Release date
2020-01-08

17583-10-7, 2-AMINO-5,6-DIHYDRO-1,3-BENZOTHIAZOL-7(4H)-ONERelated Search:

N-(5,5-DIMETHYL-7-OXO-4,5,6-TRIHYDROBENZOTHIAZOL-2-YL)ETHANAMIDE 2-AMINO-5,5-DIMETHYL-5,6-DIHYDROBENZOTHIAZOL-7(4H)-ONE 2-AMINO-5-METHYL-4,5,6-TRIHYDROBENZOTHIAZOL-7-ONE N-(5,5-DIMETHYL-7-OXO(4,5,6-TRIHYDROBENZOTHIAZOL-2-YL))(2-PHENOXY(3-PYRIDYL))FORMAMIDE 2-(4-CHLOROPHENYLTHIO)-N-(7-OXO-5-PHENYL(4,5,6-TRIHYDROBENZOTHIAZOL-2-YL))PROPANAMIDE N-(5,5-DIMETHYL-7-OXO(4,5,6-TRIHYDROBENZOTHIAZOL-2-YL))-3-PYRIDYLFORMAMIDE N-(5-(2-METHYLPROPYL)-7-OXO(4,5,6-TRIHYDROBENZOTHIAZOL-2-YL))-2-THIENYLFORMAMIDE 2-(2,4-DICHLOROPHENOXY)-N-(5,5-DIMETHYL-7-OXO(4,5,6-TRIHYDROBENZOTHIAZOL-2-YL))ETHANAMIDE N-(5,5-DIMETHYL-7-OXO(4,5,6-TRIHYDROBENZOTHIAZOL-2-YL))(4-METHOXYPHENYL)FORMAMIDE N-(5-METHYL-7-OXO(4,5,6-TRIHYDROBENZOTHIAZOL-2-YL))(4-METHYLPHENYL)FORMAMIDE 2-AMINO-5-PHENYL-5,6-DIHYDRO-1,3-BENZOTHIAZOL-7(4H)-ONE N-(5,5-DIMETHYL-7-OXO(4,5,6-TRIHYDROBENZOTHIAZOL-2-YL))-4-METHYLPENT-2-ENAMIDE N-(5-METHYL-7-OXO(4,5,6-TRIHYDROBENZOTHIAZOL-2-YL))(2-PHENOXY(3-PYRIDYL))FORMAMIDE 2-AMINO-5-(2-METHYLPROPYL)-4,5,6-TRIHYDROBENZOTHIAZOL-7-ONE N-(5,5-DIMETHYL-7-OXO(4,5,6-TRIHYDROBENZOTHIAZOL-2-YL))(2-CHLORO(3-PYRIDYL))FORMAMIDE N-(5,5-DIMETHYL-7-OXO(4,5,6-TRIHYDROBENZOTHIAZOL-2-YL))-2-(4-CHLOROPHENYLTHIO)PROPANAMIDE N-(7-OXO-5-PHENYL-4,5,6-TRIHYDROBENZOTHIAZOL-2-YL)ETHANAMIDE (2-CHLORO(3-PYRIDYL))-N-(5-METHYL-7-OXO(4,5,6-TRIHYDROBENZOTHIAZOL-2-YL))FORMAMIDE

  • IFLAB-BB F1303-0001
  • 2-amino-5,6-dihydrobenzo[d]thiazol-7(4H)-one
  • 2-AMINO-5,6-DIHYDRO-1,3-BENZOTHIAZOL-7(4H)-ONE
  • 2-AMINO-5,6-DIHYDRO-4H-BENZOTHIAZOL-7-ONE
  • 7(4H)-Benzothiazolone, 2-aMino-5,6-dihydro-
  • 2-amino-5,6-dihydro-7(4H)-Benzothiazolone
  • 2-amino-5,6-dihydro-4H-1,3-benzothiazol-7-one
  • 2-Amino-5,6-Dihydro-4H-Benzothiazol-7-One(WX140896)
  • 2-Amino-5,6-dihydrobenzothiazol-7(4H)-one
  • 3-BENZOTHIAZOL-7(4H)-ONE
  • 17583-10-7