2-CHLOROQUINAZOLIN-4-AMINE

Product Name: 2-CHLOROQUINAZOLIN-4-AMINE
CAS No.: 59870-43-8
Chemical Name: 2-CHLOROQUINAZOLIN-4-AMINE
Synonyms: Nsc75185;IFLAB-BB F2108-0111;2-CHLOROQUINAZOLIN-4-AMINE;2-chloro-4-Quinazolinamine;4-Amino-2-chloroquinazoline;4-Quinazolinamine,2-chloro-;2-Chloro-4-aminoquinazoline;2-Chloroquinazolin-4-ylamine
CBNumber: CB7329616
Molecular Formula: C8H6ClN3
Formula Weight: 179.61
MOL File: 59870-43-8.mol

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2-CHLOROQUINAZOLIN-4-AMINE Property

storage temp.: 2-8°C(protect from light)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C895655
Product name: 2-Chloroquinazolin-4-amine
Packaging: 50mg
Price: $130
Updated: 2021/12/16

TRC

Product number: C895655
Product name: 2-Chloroquinazolin-4-amine
Packaging: 100mg
Price: $200
Updated: 2021/12/16

AK Scientific

Product number: 8921AB
Product name: 2-Chloroquinazolin-4-amine
Packaging: 100mg
Price: $103
Updated: 2021/12/16

AK Scientific

Product number: 8921AB
Product name: 2-Chloroquinazolin-4-amine
Packaging: 250mg
Price: $130
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0142857
Product name: 2-CHLOROQUINAZOLIN-4-AMINE
Purity: 98.00%
Packaging: 5MG
Price: $500.7
Updated: 2021/12/16

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2-CHLOROQUINAZOLIN-4-AMINE Chemical Properties,Usage,Production

Synthesis

607-68-1

59870-43-8

General procedure for the synthesis of 2-chloroquinazolin-4-amine using 2,4-dichloroquinazoline as starting material: 2,4-dichloroquinazoline (2.0 g, 10 mmol) was dissolved in tetrahydrofuran (THF, 10 mL), followed by addition of ammonia (28-30%, 18 mL). The reaction mixture was stirred at room temperature overnight. After completion of the reaction, the reaction mixture was diluted with ethyl acetate (EtOAc) and washed sequentially with saturated sodium bicarbonate (NaHCO3) solution, water and brine. The organic phase was dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. The resulting crude product was washed with ethyl acetate (EtOAc) to afford 2-chloroquinazolin-4-amine (1.3 g, 72% yield) as a white solid. The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 7.52-7.48 (m, 1H), 7.6-7.58 (m, 1H), 7.8-7.76 (m, 1H), 8.22-8.20 (m, 1H), 8.32 (bs, 2H).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2000, vol. 10, # 11, p. 1175 - 1179
[2] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 10, p. 2565 - 2569
[3] Patent: US2008/306053, 2008, A1. Location in patent: Page/Page column 65
[4] Journal of the American Chemical Society, 1948, vol. 70, p. 4264
[5] Journal of Medicinal Chemistry, 2008, vol. 51, # 24, p. 7855 - 7865

2-CHLOROQUINAZOLIN-4-AMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLOROQUINAZOLIN-4-AMINE Suppliers

Canada 1 China 50 India 1 United States 7 Global 59

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59870-43-8, 2-CHLOROQUINAZOLIN-4-AMINERelated Search:

Moclobemide Benzalkonium chloride 2-CHLORO-6,7-DIMETHOXY-4-(1-PIPERIDINYL)QUINAZOLINE 3,4-DICHLOROBENZENECARBALDEHYDE N-(2-CHLORO-4-QUINAZOLINYL)HYDRAZONE 2-chloro-6,7-dimethoxy-4-(4-methyl-1-piperazinyl)quinazoline 4-AMINO-2-CHLORO-6,7,8-TRIMETHOXYQUINAZOLINE 2-Chloro-4-amino-6,7-dimethoxyquinazoline 3-CHLOROBENZENECARBALDEHYDE N-(2-CHLORO-4-QUINAZOLINYL)HYDRAZONE 2,4-DICHLOROBENZENECARBALDEHYDE N-(2-CHLORO-4-QUINAZOLINYL)HYDRAZONE 4-CHLOROBENZENECARBALDEHYDE N-(2-CHLORO-4-QUINAZOLINYL)HYDRAZONE 2-(2-chloro-6,7-dimethoxy-4-quinazolinyl)hydrazinecarboxamide 2,6-DICHLOROQUINAZOLIN-4-AMINE 2-FLUOROBENZENECARBALDEHYDE N-(2-CHLORO-4-QUINAZOLINYL)HYDRAZONE 4-BROMOBENZENECARBALDEHYDE N-(2-CHLORO-4-QUINAZOLINYL)HYDRAZONE 2-chloro-6,7-dimethoxy-4-(4-morpholinyl)quinazoline

IFLAB-BB F2108-0111

2-CHLOROQUINAZOLIN-4-AMINE

2-Chloroquinazolin-4-ylamine

2-chloro-4-Quinazolinamine

2-Chloro-4-aminoquinazoline

Nsc75185

4-Quinazolinamine,2-chloro-

4-Amino-2-chloroquinazoline

59870-43-8