Oteseconazole
- Product Name
- Oteseconazole
- CAS No.
- 1340593-59-0
- Chemical Name
- Oteseconazole
- Synonyms
- VT-1161;Otconazole;Otoconazole;Oteseconazole;VT-1161/Oteseconazole;Mavacamten Impurity 31;Oteseconazole Impurity;Oteseconazole Impurity 1;Oteseconazole 1340593-59-0;Oteseconazole, 10 mM in DMSO
- CBNumber
- CB73303244
- Molecular Formula
- C23H16F7N5O2
- Formula Weight
- 527.4
- MOL File
- 1340593-59-0.mol
Oteseconazole Property
- Boiling point:
- 609.2±65.0 °C(Predicted)
- Density
- 1.47±0.1 g/cm3(Predicted)
- vapor pressure
- 0-0Pa at 20-50℃
- storage temp.
- Store at -20°C
- solubility
- DMSO: ≥ 270 mg/mL (511.96 mM)
- form
- Solid
- pka
- 10.49±0.29(Predicted)
- color
- White to off-white
- LogP
- 4.41 at 45℃ and pH0-14
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H373May cause damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P314Get medical advice/attention if you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-0016914
- Product name
- Oteseconazole
- Purity
- 99.56%
- Packaging
- 5mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- CS-0016914
- Product name
- Oteseconazole
- Purity
- 99.56%
- Packaging
- 10mg
- Price
- $550
- Updated
- 2021/12/16
- Product number
- CS-0016914
- Product name
- Oteseconazole
- Purity
- 99.56%
- Packaging
- 25mg
- Price
- $990
- Updated
- 2021/12/16
- Product number
- CS-0016914
- Product name
- Oteseconazole
- Purity
- 99.56%
- Packaging
- 50mg
- Price
- $1650
- Updated
- 2021/12/16
Oteseconazole Chemical Properties,Usage,Production
Description
Oteseconazole (trade name Vivjoa) is an antifungal drug that was approved by the United States Food and Drug Administration (USFDA) in April 2022 for the treatment of recurrent vaginal candidiasis in women who have a history of recurrent vaginal candidiasis and are not of reproductive potential.
Uses
Oteseconazole (Standard) is the analytical standard of Oteseconazole. This product is intended for research and analytical applications. Oteseconazole (VT-1161) is a potent and orally active anti-fungal agent. Oteseconazole potently binds to and inhibits Candida albicans cytochrome P45051 (CYP51) activity (Kd ≤39 nM), shows no obvious effect on human CYP51. Oteseconazole also can be used for the research of dermatophytes.
Definition
ChEBI: Oteseconazole is an organic molecular entity.
Mechanism of action
The antifungal activity of Oteseconazole has been attributed to its inhibition of ergosterol 14-alpha demethylase (CYP51), a cytochrome P450 enzyme involved in the biosynthesis of ergosterol, a component required for the maintenance of fungal cell membrane integrity.
Synthesis
To complete the synthesis of orticonazole, the resolved amino alcohol 5.8 was first subjected to salting out and then Suzuki coupling with boronic acid 5.9 to afford the biaryl product 5.10 as the L-tartrate salt. Conversion of 5.10 to orticonazole was accomplished using TMSN3 in acetic acid in the presence of sodium acetate and trimethoxyformate. The reaction solution was treated with a palladium adsorbent and subsequently recrystallized from ethanol and water after adjusting the pH with potassium carbonate. Oteseconazole was isolated in hydrated form in 85% yield.
Oteseconazole Preparation Products And Raw materials
Raw materials
Preparation Products
Oteseconazole Suppliers
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View Lastest Price from Oteseconazole manufacturers
- Product
- Oteseconazole 1340593-59-0
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 95%+
- Supply Ability
- 10000000
- Release date
- 2025-02-27
- Product
- Oteseconazole 1340593-59-0
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- More Than 99%
- Supply Ability
- 100kg/Month
- Release date
- 2024-07-19
- Product
- Oteseconazole. 1340593-59-0
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- More Than 99%
- Supply Ability
- 100kg/Month
- Release date
- 2024-12-30