METICRANE

Product Name: METICRANE
CAS No.: 1084-65-7
Chemical Name: METICRANE
Synonyms: COL4A1;e-103-e;SD 17102;Arresten;fontiliz;meticran;SD-171-02;METICRANE;Collagen α-1(IV) chain;6-methyl-7-sulfamido-thiochroman-1,1-dioxide
CBNumber: CB7331774
Molecular Formula: C10H13NO4S2
Formula Weight: 275.34
MOL File: 1084-65-7.mol

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METICRANE Property

Melting point:: 236-237°
Boiling point:: 549.1±60.0 °C(Predicted)
Density: 1.4366 (rough estimate)
refractive index: 1.6800 (estimate)
storage temp.: Sealed in dry,2-8°C
solubility: ≥ 12.45mg/mL in DMSO
pka: 9.71±0.20(Predicted)
EPA Substance Registry System: 2H-1-Benzothiopyran-7-sulfonamide, 3,4-dihydro-6-methyl-, 1,1-dioxide (1084-65-7)

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Safety

WGK Germany: 2
RTECS: XK6360000
Toxicity: mouse,LD50,intraperitoneal,10gm/kg (10000mg/kg),Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 217, 1974.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M6902
Product name: Meticrane
Purity: analytical standard
Packaging: 5g
Price: $89.5
Updated: 2022/05/15

Usbiological

Product number: 354903
Product name: COL4A1
Packaging: 48Tests
Price: $588
Updated: 2021/12/16

Usbiological

Product number: 354904
Product name: COL4A1
Packaging: 48Tests
Price: $588
Updated: 2021/12/16

Usbiological

Product number: 382459
Product name: COL4a1
Packaging: 96Tests
Price: $729
Updated: 2021/12/16

Usbiological

Product number: 382458
Product name: COL4a1
Packaging: 96Tests
Price: $729
Updated: 2021/12/16

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METICRANE Chemical Properties,Usage,Production

Originator

Fontilix,Diamant

Uses

diuretic, antihypertensive

Definition

ChEBI: Meticrane is a thiochromane.

Manufacturing Process

64.5 g of 6-methylthiachromane were dissolved in 500 ml of acetic acid and 250 ml of 110-volume hydrogen peroxide were added. The solution was placed on a water bath for 1.5 hour; it was then diluted with iced water, the precipitate obtained was recovered, and this was washed and dried. There were obtained 59.6 g of 6-methylthiachromane-1,1-dioxide (yield: 77.5%; melting point 79°-81°C).
52 g of this product were added to 250 ml of chlorosulfonic acid and the mixture was placed on a water bath at a temperature of 70°-75°C for 2 hours. It was allowed to cool and poured onto crushed ice; the product was extracted by means of chloroform, the extracted solutions were washed and the chloroform was evaporated. There were obtained 67 g of crude 6-methyl- 7-chloro-sulfonyl-thiachromane-1,1-dioxide (yield: 86%; melting point 158°- 161°C).
47 g of this sulfochloride were introduced into 200 ml of liquid ammonia. The mixture was left to stand at ambient temperature until the ammonia evaporated. The residue was taken up in water and the solution was acidified. The precipitate formed was centrifuged, washed with water and dried. There were obtained 30.8 g of 6-methyl-7-sulfamido-thiachromane-1,1-dioxide, recrystallized from 2-methoxy ethanol (yield: 49%; MP: 236°-237°C).

Therapeutic Function

Diuretic

METICRANE Preparation Products And Raw materials

Raw materials

Preparation Products

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METICRANE Suppliers

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View Lastest Price from METICRANE manufacturers

Career Henan Chemical Co

Product: 6-methyl-1,1-dioxo-3,4-dihydro-2H-thiochromene-7-sulfonamide 1084-65-7
Price: US $9.80/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 20 tons
Release date: 2020-01-09

1084-65-7, METICRANERelated Search:

2-Isopropylthioxanthone METICRANE 1-METHANESULFONYL-2-METHYL-BENZENE 4-Ethylbenzenesulfonamide 2,4-DIMETHYL-1-(METHYLSULFONYL)BENZENE 3-PHENYL-1-PROPANETHIOL

thiochroman-7-sulfonamide,6-methyl-,1,1-dioxide

METICRANE

6-METHYL-1-THIA-1,2,3,4-TETRA-HYDRONAPHTHALENE-7-SULFONAMIDE 1,1-DIOXIDE

3,4-DIHYDRO-6-METHYL-2H-1-BENZOTHIOPYRAN-7-SULFONAMIDE-1,1-DIOXIDE

Arresten

SD 17102

SD-171-02

1,1-diketo-6-methyl-3,4-dihydro-2H-thiochromene-7-sulfonamide

6-methyl-1,1-dioxo-3,4-dihydro-2H-thiochromene-7-sulfonamide

Anti-Collagen IV, N-Terminal antibody produced in rabbit

COL4A1

Collagen α-1(IV) chain

2h-1-benzothiopyran-7-sulfonamide,3,4-dihydro-6-methyl-,1,1-dioxide

6-methyl-3,4-dihydro-2h-1-benzothiopyran-7-sulfonamide1,1-dioxide

6-methyl-7-sulfamido-thiochroman-1,1-dioxide

6-methylthiochroman-7-sulfonamide1,1-dioxide

e-103-e

fontiliz

meticran

6-Methylthiochromane-7-sulfonamide 1,1-dioxide

Inhibitor,Cl? Channels,Sodium Channel,inhibit,Na channels,Meticrane,Chloride Channel,Na+ channels

1084-65-7

C10H13NO4S2

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