3'-O-(2-Methoxyethyl)adenosine

Product Name: 3'-O-(2-Methoxyethyl)adenosine
CAS No.: 303197-30-0
Chemical Name: 3'-O-(2-Methoxyethyl)adenosine
Synonyms: 3'-MOE-Adenosine;-O-(2-Methoxyethyl)adenosine;3'-O-(2-Methoxyethyl)adenosine;3'-O-(2-Methoxyethyl)adeno sine;Adenosine, 3'-O-(2-methoxyethyl)-;(2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-ol
CBNumber: CB73334255
Molecular Formula: C13H19N5O5
Formula Weight: 325.32
MOL File: 303197-30-0.mol

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3'-O-(2-Methoxyethyl)adenosine Property

Boiling point:: 639.0±65.0 °C(Predicted)
Density: 1.70±0.1 g/cm3(Predicted)
solubility: DCM
pka: 12.97±0.70(Predicted)
InChI: InChI=1S/C13H19N5O5/c1-21-2-3-22-10-7(4-19)23-13(9(10)20)18-6-17-8-11(14)15-5-16-12(8)18/h5-7,9-10,13,19-20H,2-4H2,1H3,(H2,14,15,16)/t7-,9-,10-,13-/m1/s1
InChIKey: RHVMAYVXDAXYHR-QYVSTXNMSA-N
SMILES: OC[C@H]1O[C@@H](N2C3C(=C(N=CN=3)N)N=C2)[C@H](O)[C@@H]1OCCOC

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: M304265
Product name: 3''-O-(2-Methoxyethyl)adenosine
Packaging: 250mg
Price: $1320
Updated: 2021/12/16

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3'-O-(2-Methoxyethyl)adenosine Chemical Properties,Usage,Production

Description

3'-O-(2-Methoxyethyl)adenosine is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression.

Uses

3''-O-(2-Methoxyethyl)adenosine is an adenosine derivative as building blocks for cross-linking oligonucleotides.

Synthesis

26.0 g of ((2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-(benzoyloxy)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)methyl benzoate was weighed, and 8.1 g of adenine was suspended in 250 mL of acetonitrile and 1,2-dichloroethane, and the temperature was lowered to 10 ° C. Add 26.1g of tin tetrachloride. After the completion of the dropwise addition, the reaction was stirred at 25 °C. After the completion of the reaction by HPLC, it was quenched with water. The reaction mixture was diluted with methylene chloride, washed with water, and evaporated. The evaporated crude product was dissolved in 200 mL of methanol / aqueous ammonia and stirred at 25 ° C overnight. After completion of the reaction, the mixture was concentrated and purified to give the product 3'-O-methoxyethyl adenosine 12.1 g, purity 99.6%, yield 70%.

3'-O-(2-Methoxyethyl)adenosine Preparation Products And Raw materials

Raw materials

Preparation Products

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303197-30-0, 3'-O-(2-Methoxyethyl)adenosineRelated Search:

3'-O-(2-Methoxyethyl)adenosine

-O-(2-Methoxyethyl)adenosine

3'-MOE-Adenosine

Adenosine, 3'-O-(2-methoxyethyl)-

(2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-ol

3'-O-(2-Methoxyethyl)adeno sine

303197-30-0