3-(5-hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione
- Product Name
- 3-(5-hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione
- CAS No.
- 1416990-08-3
- Chemical Name
- 3-(5-hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione
- Synonyms
- Lenalidomide-OH;Lenalidomide-OH, 10 mM in DMSO;3-(5-hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-Hydroxy-1-oxo-2-isoindolinyl)piperidine-2,6-dione;3-(6-hydroxy-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione;3-(5-hydroxy-1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione;3-(1,3-Dihydro-5-hydroxy-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione;2,6-Piperidinedione, 3-(1,3-dihydro-5-hydroxy-1-oxo-2H-isoindol-2-yl)-;LenalidomideOH,inhibit,E3 ligase-recruiting Moiety,Lenalidomide-OH,Inhibitor,Ligands for E3 Ligase,Lenalidomide OH
- CBNumber
- CB73336097
- Molecular Formula
- C13H12N2O4
- Formula Weight
- 260.25
- MOL File
- 1416990-08-3.mol
3-(5-hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione Property
- Boiling point:
- 631.5±55.0 °C(Predicted)
- Density
- 1.498±0.06 g/cm3(Predicted)
- storage temp.
- Storage temp. 2-8°C
- pka
- 8.32±0.20(Predicted)
- form
- Solid
- color
- Off-white to gray
- InChI
- InChI=1S/C13H12N2O4/c16-8-1-2-9-7(5-8)6-15(13(9)19)10-3-4-11(17)14-12(10)18/h1-2,5,10,16H,3-4,6H2,(H,14,17,18)
- InChIKey
- JJUMFQGCQAUIFH-UHFFFAOYSA-N
- SMILES
- N1C(=O)CCC(N2CC3=C(C2=O)C=CC(O)=C3)C1=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- AR01JMJU
- Product name
- 3-(5-Hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione
- Purity
- 97%
- Packaging
- 100mg
- Price
- $122
- Updated
- 2021/12/16
- Product number
- AR01JMJU
- Product name
- 3-(5-Hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione
- Purity
- 97%
- Packaging
- 250mg
- Price
- $191
- Updated
- 2021/12/16
- Product number
- AS01322
- Product name
- 3-(5-Hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione
- Purity
- 97%
- Packaging
- 0.5g
- Price
- $293.3
- Updated
- 2021/12/16
- Product number
- AA01JLS2
- Product name
- 3-(5-Hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione
- Purity
- 97%
- Packaging
- 250mg
- Price
- $381
- Updated
- 2021/12/16
- Product number
- AR01JMJU
- Product name
- 3-(5-Hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione
- Purity
- 97%
- Packaging
- 1g
- Price
- $391
- Updated
- 2021/12/16
3-(5-hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione Chemical Properties,Usage,Production
Uses
Lenalidomide-OH is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BTK degrader SJF620 (HY-133137)[1].
IC 50
Cereblon
References
[1] Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30(3):126877. DOI:10.1016/j.bmcl.2019.126877
3-(5-hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione Preparation Products And Raw materials
Raw materials
Preparation Products
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