Banoxantrone (dihydrochloride)

Product Name: Banoxantrone (dihydrochloride)
CAS No.: 252979-56-9
Chemical Name: Banoxantrone (dihydrochloride)
Synonyms: Banoxantrone 2HCl;AQ4N dihydrochloride;Banoxantrone dihydrochloride >=98% (HPLC);Banoxantrone dihydrochloride, 10 mM in DMSO;Banoxantrone dihydrochloride (AQ4N dihydrochloride);Banoxantrone dihydrochloride (AQ4N), Topoisomerase II inhibitor;1,4-Bis[[2-(dimethyloxidoamino)ethyl]amino]-5,8-dihydroxy-9,10-anthracenedione dihydrochloride;9,10-Anthracenedione, 1,4-bis[[2-(dimethyloxidoamino)ethyl]amino]-5,8-dihydroxy-, hydrochloride;2,2'-((5,8-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-1,4-diyl)bis(azanediyl))bis(N,N-dimethylethanamine oxide) dihydrochloride;2,2'-((5,8-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-1,4-diyl)bis(azanediyl))bis(N,N-dimethylethanamine oxide) dihydrochloride
CBNumber: CB73339609
Molecular Formula: C22H29ClN4O6
Formula Weight: 480.95
MOL File: 252979-56-9.mol

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Banoxantrone (dihydrochloride) Property

storage temp.: Store at -20°C, protect from light, stored under nitrogen
solubility: Soluble to 50 mM in water and to 25 mM in DMSO
form: Solid
color: Blue to dark blue
Water Solubility: Water : 25 mg/mL (48.32 mM)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H350May cause cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1854
Product name: Banoxantrone dihydrochloride
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $135
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1854
Product name: Banoxantrone dihydrochloride
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $437
Updated: 2025/07/31

TRC

Product number: B129285
Product name: BanoxantroneDihydrochloride
Packaging: 2.5mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-6986
Product name: Banoxantronedihydrochloride
Purity: 99.17%
Packaging: 5mg
Price: $96
Updated: 2021/12/16

ChemScene

Product number: CS-6986
Product name: Banoxantronedihydrochloride
Purity: 99.17%
Packaging: 10mg
Price: $168
Updated: 2021/12/16

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Banoxantrone (dihydrochloride) Chemical Properties,Usage,Production

Uses

Banoxantrone (AQ4N) is a hypoxia-activated prodrug of topoisomerase II inhibitor AQ4 (Bioreductive AQ4 precursor). studies have shown that its has also exhibited anti-tumor efficacy in vivo when combined with oxic cell cytotoxins.

Biological Activity

Banoxantrone (AQ4N) is a hypoxia-activated prodrug of topoisomerase II inhibitor AQ4 (Bioreductive AQ4 precursor).', 'Banoxantrone dihydrochloride enhances the anti-tumor effect caused by radiation.

in vivo

Banoxantrone (200 mg/kg) significantly enhances the tumor growth delay caused by radiation. This occurred when radiation is administered both as a single dose (12 Gy) and in a multifraction regimen (5x3 Gy). A study of the scheduling of Banoxantrone (AQ4N) administration shows that there is a very long time period over which a maximal effect can be elicited (drug given 4 days before to 6 h after radiation). These results suggest that Banoxantrone has significant potential as a bioreductive drug^[1]. The activation of banoxantrone cytotoxicity in vivo requires tumor hypoxia that is more extensive or prolonged than can readily be achieved by vasodilation or by antiangiogenic drug treatment^[2]. Incorporation of banoxantrone into conventional chemoradiation protocols therefore targets both oxygenated and hypoxic regions of tumors, and potentially will increase the effectiveness of therapy. A single dose of 60 mg/kg banoxantrone enhances the response of RT112 (bladder) and Calu-6 (lung) xenografts to treatment with cisplatin and radiation therapy. Banoxantrone will increase the efficacy of chemoradiotherapy in preclinical models^[3].

IC 50

Topoisomerase II

storage

Store at +4°C

Banoxantrone (dihydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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Banoxantrone (dihydrochloride) Suppliers

China 32 United Kingdom 1 United States 8 Global 41

Nanjing Chemlin Chemical Co., Ltd

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252979-56-9, Banoxantrone (dihydrochloride)Related Search:

Banoxantrone 2HCl

1,4-Bis[[2-(dimethyloxidoamino)ethyl]amino]-5,8-dihydroxy-9,10-anthracenedione dihydrochloride

AQ4N dihydrochloride

Banoxantrone dihydrochloride >=98% (HPLC)

2,2'-((5,8-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-1,4-diyl)bis(azanediyl))bis(N,N-dimethylethanamine oxide) dihydrochloride , Banoxantrone 2HCl

2,2'-((5,8-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-1,4-diyl)bis(azanediyl))bis(N,N-dimethylethanamine oxide) dihydrochloride

Banoxantrone dihydrochloride (AQ4N), Topoisomerase II inhibitor

Banoxantrone dihydrochloride, 10 mM in DMSO

2,2'-((5,8-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-1,4-diyl)bis(azanediyl))bis(N,N-dimethylethanamine oxide) dihydrochloride

Banoxantrone dihydrochloride (AQ4N dihydrochloride)

9,10-Anthracenedione, 1,4-bis[[2-(dimethyloxidoamino)ethyl]amino]-5,8-dihydroxy-, hydrochloride

252979-56-9