BAY57-1293 mesylate

Product Name: BAY57-1293 mesylate
CAS No.: 1428333-96-3
Chemical Name: BAY57-1293 mesylate
Synonyms: AIC316 mesylate;Pritelivir mesylate;BAY57-1293 mesylate;Pritelivir mesylate (BAY 57-1293);N-Methyl-N-(4-methyl-5-sulfamoylthiazol-2-yl)-2-(4-(pyridin-2-yl)phenyl)acetamide methanesulfonate
CBNumber: CB73339856
Molecular Formula: C19H22N4O6S3
Formula Weight: 498.59
MOL File: 1428333-96-3.mol

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BAY57-1293 mesylate Property

storage temp.: Store at -20°C
solubility: DMSO : 83.33 mg/mL (167.13 mM; Need ultrasonic)
form: Solid
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: B118805
Product name: BAY57-1293MethanesulfonateSalt
Packaging: 25mg
Price: $200
Updated: 2021/12/16

TRC

Product number: B118805
Product name: BAY57-1293MethanesulfonateSalt
Packaging: 100mg
Price: $525
Updated: 2021/12/16

ChemScene

Product number: CS-0089227
Product name: Pritelivirmesylate
Purity: 98.03%
Packaging: 5mg
Price: $50
Updated: 2021/12/16

DC Chemicals

Product number: DC32351
Product name: Pritelivirmesylate
Packaging: 1g
Price: $1550
Updated: 2021/12/16

DC Chemicals

Product number: DC32351
Product name: Pritelivirmesylate
Packaging: 100mg
Price: $500
Updated: 2021/12/16

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BAY57-1293 mesylate Chemical Properties,Usage,Production

Uses

BAY 57-1293 Methanesulfonate Salt is used in biological studies as an antiviral agents for treating and preventing shingles and a method of treating zoster(herpes) associated pain as it is a potent helicase primase inhibitor.

in vivo

Pritelivir is the first in a class of antiviral agents that inhibit HSV replication by targeting the viral helicase–primase enzyme complex^[2].
Pritelivir (0.03-45 mg/kg) significantly increases survival. Pritelivir (0.3-30 mg/kg) reduces mortality against HSV-1, E-377. Pritelivir has potent and resistance-breaking antiviral efficacy with potential for the treatment of potentially life-threatening HSV type 1 and 2 infections, including herpes simplex encephalitis^[3].
Combination therapies of Pritelivir at 0.1 or 0.3 mg/kg/dose with Acyclovir (10 mg/kg/dose) are protective when compared to the vehicle treated group against HSV-2, strain MS^[3].

Animal Model:	Female BALB/c mice^[3]
Dosage:	0.03 to 45 mg/kg
Administration:	Administered orally, twice daily at approximately 12 h intervals, for 7 days
Result:	Survival was significantly increased to 80-100% as compared to the vehicle treatment. Even the lowest dose of 0.3 mg/kg was effective in increasing survival to 53%.

IC 50

HSV-1: 0.02 μM (IC₅₀); HSV-2: 0.02 μM (IC₅₀)

BAY57-1293 mesylate Preparation Products And Raw materials

Raw materials

Preparation Products

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BAY57-1293 mesylate Suppliers

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1428333-96-3, BAY57-1293 mesylateRelated Search:

BAY57-1293 mesylate

AIC316 mesylate

Pritelivir mesylate

Pritelivir mesylate (BAY 57-1293)

N-Methyl-N-(4-methyl-5-sulfamoylthiazol-2-yl)-2-(4-(pyridin-2-yl)phenyl)acetamide methanesulfonate

1428333-96-3